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1/n With respect to my colleagues involved in the GEMINI study that was just published, I am worried about the danger of a major message from this report:https://t.co/hkUeRd2nsb

— John Greally (@greally) July 14, 2023

Systematic Review | Criteria to achieve safe antimicrobial intravenous-to-oral switch in hospitalized adult populations

17 Jul, 2023 | 13:34h | UTC

Criteria to achieve safe antimicrobial intravenous-to-oral switch in hospitalised adult populations: a systematic rapid review – BMJ Open

Single-arm study | Pembrolizumab plus Lenvatinib shows potential as first-line treatment for advanced non-clear-cell renal cell carcinoma

17 Jul, 2023 | 13:33h | UTC

Pembrolizumab plus lenvatinib as first-line therapy for advanced non-clear-cell renal cell carcinoma (KEYNOTE-B61): a single-arm, multicentre, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities

17 Jul, 2023 | 13:32h | UTC

Prevalence of Neuroradiological Abnormalities in First-Episode Psychosis: A Systematic Review and Meta-analysis – JAMA Psychiatry

News Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford

Case Series | Cutibacterium acnes endocarditis often misdiagnosed due to absence of typical symptoms and delayed culture results

17 Jul, 2023 | 13:31h | UTC

Clinical Characteristics and Outcomes of Patients With Cutibacterium acnes Endocarditis – JAMA Network Open

Review | A health systems approach to critical care delivery in low-resource settings

17 Jul, 2023 | 13:29h | UTC

A health systems approach to critical care delivery in low-resource settings: a narrative review – Intensive Care Medicine

Commentary on Twitter (thread – click for more)

1/ @yourICM's highlights:

?OPEN ACCESS~ Health systems approach to #CriticalCare delivery in low-resource settings? https://t.co/W7d3q7UP1D
?OPEN ACCESS~ #ICU #Sepsis-associated #AKI? https://t.co/gLCXjcH2ah
?Myocarditis: a primer for intensivists? https://t.co/UUga5lYX0q pic.twitter.com/tB8am5zEny

— ESICM (@ESICM) July 14, 2023

Cohort Study | Intermittent hypoxemia is associated with unfavorable respiratory outcomes in extremely preterm infants

17 Jul, 2023 | 13:28h | UTC

Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants – American Journal of Respiratory and Critical Care Medicine

Cohort Study | Long-acting antiretroviral therapy may achieve virologic suppression in HIV patients with adherence challenges

17 Jul, 2023 | 13:26h | UTC

Demonstration Project of Long-Acting Antiretroviral Therapy in a Diverse Population of People With HIV – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Long-Acting ART Achieves Virologic Suppression for People With HIV – HealthDay

TTMV-HPV DNA testing | Promising diagnostic and surveillance tool for HPV-linked oropharyngeal cancer

17 Jul, 2023 | 13:25h | UTC

Performance of Liquid Biopsy for Diagnosis and Surveillance of Human Papillomavirus–Associated Oropharyngeal Cancer – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

Invited Commentary: Circulating Human Papillomavirus Tumor DNA—Ready for Prime Time? – – JAMA Otolaryngology–Head & Neck Surgery (free for a limited period)

Review | Guiding the use of invasive cardiac interventions in patients with advanced malignancies

17 Jul, 2023 | 13:23h | UTC

Invasive Cardiac Interventions in Patients With Active, Advanced Solid and Hematologic Malignancies: A Conceptual Framework: JACC: CardioOncology State-of-the-Art Review – JACC: CardioOncology

Cohort Study | Mental disorders linked to increased cardiovascular events in young patients

17 Jul, 2023 | 13:20h | UTC

Increased cardiovascular events in young patients with mental disorders: a nationwide cohort study – European Journal of Preventive Cardiology (free for a limited period)

News Release: Under 40s with mental health problems have elevated risks of heart attack and stroke – European Society of Cardiology

Brief Review | Neurological diseases in intensive care

17 Jul, 2023 | 13:19h | UTC

Neurological diseases in intensive care – Intensive Care Medicine

Commentary on Twitter

Neurological diseases in #ICU
◼️ black box of neurocritical care
? heterogeneity of care
⏳ impact of early interventions on long‑term outcomes
? side effects of medical treatments/unexpected trial results
? neuro-prognostication#FOAMcc @yourICM
?️ https://t.co/w3GUhQGGGs pic.twitter.com/fzkRghKHB2

— Intensive Care Medicine (@yourICM) July 12, 2023

RCT | 4-week course of subcutaneous ketamine shows efficacy in treatment-resistant depression

17 Jul, 2023 | 13:17h | UTC

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial – British Journal of Psychiatry

News Release: Ketamine effective for treatment-resistant depression: Clinical trial – University of New South Wales

M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode

RCT | Assessing low-dose ketamine’s antidepressant & antisuicidal effects in patients with treatment-resistant depression

M-A | Efficacy and safety of ketamine vs. electroconvulsive therapy among patients with major depressive episode.

Consensus Paper | Implementing strategies to prevent infections in acute-care settings

14 Jul, 2023 | 13:03h | UTC

Implementing strategies to prevent infections in acute-care settings – Infection Control & Hospital Epidemiology

News Release: New guidance for infection prevention in acute care settings – Society for Healthcare Epidemiology of America

Consensus Paper | Strategies to prevent surgical site infections in acute-care hospitals

Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals

SHEA/IDSA/APIC Practice Recommendation: Strategies to prevent healthcare-associated infections through hand hygiene: 2022 Update – Infection Control & Hospital Epidemiology

SHEA statement on antibiotic stewardship in hospitals during public health emergencies – Infection Control & Hospital Epidemiology

Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

Consensus Statement | Aerosol therapy in adult critically ill patients

14 Jul, 2023 | 13:01h | UTC

Aerosol therapy in adult critically ill patients: a consensus statement regarding aerosol administration strategies during various modes of respiratory support – Annals of Intensive Care

M-A | First-line thiazide diuretics show reduced cardiovascular events, comparable mortality vs. other antihypertensive drugs

14 Jul, 2023 | 12:55h | UTC

First‐line diuretics versus other classes of antihypertensive drugs for hypertension – Cochrane Library

Summary: What are the benefits and harms of diuretics given as a first treatment compared to other drug classes for hypertension (high blood pressure)? – Cochrane Library

Quality Improvement Study | Improved asymptomatic bacteriuria management by reduction of unnecessary urine culture requests

14 Jul, 2023 | 12:54h | UTC

A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria – JAMA Internal Medicine

Study: Hospital Intervention Resulted in a 45% Reduction in the Urine Cultures Ordered

Optimal Urine Culture Diagnostic Stewardship Practice—Results from an Expert Modified-Delphi Procedure – Clinical Infectious Diseases

USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults

Cohort Study: Antibiotic Treatment of Asymptomatic Bacteriuria in Hospitalized Patients is Common, and May be Associated with Longer Duration of Hospitalization

Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis – Open Forum Infectious Diseases

IDSA Guideline for the Management of Asymptomatic Bacteriuria

Commentary on Twitter

???Powerful message from our new study in @JAMAInternalMed: diagnostic stewardship (better use of diagnostic tests) was responsible for ALL the⬇️in unnecessary antibiotic use for ASB. ➕results??nudge to action. Time to??upstream to improve care! https://t.co/yO4UpA6ZKK pic.twitter.com/hXZGvNmVJP

— Valerie Vaughn (@ValerieVaughnMD) July 11, 2023