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Phase 2 RCT | Immediate surgery vs. short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer.

14 Dec, 2022 | 15:01h | UTC

Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial – The Lancet Gastroenterology & Hepatology

News Release: Chemotherapy before surgery can improve survival rates in pancreatic cancer patients – University of Liverpool

 

Commentary on Twitter

 


RCT | Medication optimization vs. cognitive behavioral therapy in patients with chronic low back pain.

14 Dec, 2022 | 14:58h | UTC

Effect of Medication Optimization vs Cognitive Behavioral Therapy Among US Veterans With Chronic Low Back Pain Receiving Long-term Opioid Therapy: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


RCT | Small trial suggests butyrate may be effective in reducing pediatric obesity.

14 Dec, 2022 | 14:56h | UTC

Therapeutic Effects of Butyrate on Pediatric Obesity: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 


SR | Use of acupuncture for adult health conditions, 2013 to 2021.

14 Dec, 2022 | 14:54h | UTC

Use of Acupuncture for Adult Health Conditions, 2013 to 2021: A Systematic Review – JAMA Network Open

 


SR | Fundoplication in laparoscopic Heller’s cardiomyotomy for achalasia.

14 Dec, 2022 | 14:53h | UTC

Fundoplication in laparoscopic Heller’s cardiomyotomy for achalasia – Cochrane Library

Summary: Addition of a stomach wrap (fundoplication) around the food pipe (oesophagus) in keyhole (laparoscopic) surgery to treat achalasia – Cochrane Library

 


SR | BNP and NT-proBNP for the diagnosis of hemodynamically significant patent ductus arteriosus in preterm neonates.

14 Dec, 2022 | 14:49h | UTC

Brain natriuretic peptide and N‐terminal brain natriuretic peptide for the diagnosis of haemodynamically significant patent ductus arteriosus in preterm neonates – Cochrane Library

Summary: In preterm infants, how accurate are the blood tests BNP and NT-proBNP in identifying PDAs (patent ductus arteriosus) that require further treatment? – Cochrane Library

 


SR | Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins.

14 Dec, 2022 | 14:51h | UTC

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins – Cochrane Library

 


Podcast | Prostate cancer: screening, advanced testing, and survivorship.

14 Dec, 2022 | 14:48h | UTC

#371 Prostate Cancer: Screening, Advanced Testing, and Survivorship – The Curbsiders

 


RCT | Optimal treatment duration of bevacizumab as front-line therapy for advanced ovarian cancer.

14 Dec, 2022 | 14:44h | UTC

Optimal Treatment Duration of Bevacizumab as Front-Line Therapy for Advanced Ovarian Cancer: AGO-OVAR 17 BOOST/GINECO OV118/ENGOT Ov-15 Open-Label Randomized Phase III Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: Treatment With Bevacizumab for 30 Months Provides No Benefit Over 15 Months in Ovarian Cancer – Cancer Network

 

Commentary on Twitter

 


RCT | Durvalumab with or without Tremelimumab plus chemotherapy for metastatic non–small-cell lung cancer.

14 Dec, 2022 | 14:47h | UTC

Durvalumab With or Without Tremelimumab in Combination With Chemotherapy as First-Line Therapy for Metastatic Non–Small-Cell Lung Cancer: The Phase III POSEIDON Study – Journal of Clinical Oncology

Commentary: Adding Tremelimumab and Durvalumab to Chemo Improves PFS, OS in mNSCLC – Cancer Therapy Advisor

 

Commentary on Twitter

 


RCT | Rogaratinib vs. chemotherapy in patients with advancer urothelial carcinoma selected based on FGFR1/3 mRNA expression.

14 Dec, 2022 | 14:45h | UTC

FORT-1: Phase II/III Study of Rogaratinib Versus Chemotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Selected Based on FGFR1/3 mRNA Expression – Journal of Clinical Oncology

Commentary: Rogaratinib Is Noninferior to Chemo in Pretreated FGFR1/3 mRNA+ Locally Advanced or Metastatic Urothelial Carcinoma – OncLive

 

Commentary on Twitter

 


Post-trial follow-up | Radiotherapy vs. surgery of the axilla after a positive sentinel node in breast cancer.

14 Dec, 2022 | 14:42h | UTC

Radiotherapy or Surgery of the Axilla After a Positive Sentinel Node in Breast Cancer: 10-Year Results of the Randomized Controlled EORTC 10981-22023 AMAROS Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: ART Preferred Over ALND in Sentinel Node-Positive Early Breast Cancer – Cancer Therapy Advisor

 


AHA Scientific Statement | Management of acute coronary syndrome in the older adult population.

13 Dec, 2022 | 14:35h | UTC

Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association – Circulation

News Release: Hearts and bodies change with age, heart disease treatments may need to change, too – American Heart Association

Top Things to Know: Management of ACS in the Older Adult Population – American Heart Association

Commentaries: 

The Management of ACS in Older Patients: Is Age Just a Number? – American Heart Association

Cardiovascular Aging and Acute Coronary Syndromes: Unique Challenges and Solutions for Our Elderly Patients – American Heart Association

 


Guideline | Postoperative pain management in non-traumatic emergency general surgery.

13 Dec, 2022 | 14:32h | UTC

Postoperative pain management in non-traumatic emergency general surgery: WSES-GAIS-SIAARTI-AAST guidelines – World Journal of Emergency Surgery

 


Prevention of device-related infections in patients with cancer: Current practice and future horizons.

13 Dec, 2022 | 14:30h | UTC

Prevention of device-related infections in patients with cancer: Current practice and future horizons – CA: A Cancer Journal for Clinicians

 


Review | GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with Type 2 Diabetes.

13 Dec, 2022 | 14:29h | UTC

GLP-1 Receptor Agonists for the Reduction of Atherosclerotic Cardiovascular Risk in Patients With Type 2 Diabetes – Circulation (free for a limited period)

 


EANM practice guideline for quantitative SPECT-CT.

13 Dec, 2022 | 14:26h | UTC

EANM practice guideline for quantitative SPECT-CT – European Journal of Nuclear Medicine and Molecular Imaging

 


Cohort Study | Prenatal carbamazepine exposure and academic performance in adolescents.

13 Dec, 2022 | 14:22h | UTC

Prenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study – Neurology (link to abstract – $ for full-text)

 


Consensus Paper | Standardized treatment pathway algorithm for lumbar spinal stenosis.

13 Dec, 2022 | 14:25h | UTC

Consensus on a standardised treatment pathway algorithm for lumbar spinal stenosis: an international Delphi study – BMC Musculoskeletal Disorders

 


Cohort Study | Survival of patients with congenital ventricular septal defect.

13 Dec, 2022 | 14:21h | UTC

Survival of patients with congenital ventricular septal defect – European Heart Journal

Commentary: Survival of Patients With Congenital Ventricular Septal Defect – American College of Cardiology

 

Commentary on Twitter

 


Cohort Study | Long-term mortality, cardiovascular events, and bleeding in stable patients 1 year after myocardial infarction.

13 Dec, 2022 | 14:20h | UTC

Long-term mortality, cardiovascular events, and bleeding in stable patients 1 year after myocardial infarction: a Danish nationwide study – European Heart Journal

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

 


Systematic Review | Management of infantile epilepsies.

13 Dec, 2022 | 14:18h | UTC

Management of Infantile Epilepsies – Agency for Healthcare Research and Quality

 


RCT | Ropivacaine perineal infiltration after episiotomy did not reduce postpartum pain.

13 Dec, 2022 | 14:16h | UTC

Ropivacaine perineal infiltration for postpartum pain management in episiotomy repair: a double-blind, randomised, placebo-controlled trial – BJOG (link to abstract – $ for full-text)

 


SR | Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis.

13 Dec, 2022 | 14:15h | UTC

Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis – Cochrane Library

Summary: Inhaling antibiotics to treat lung infection in people with cystic fibrosis – Cochrane Library

 


Review | Chest wall loading in the ICU: pushes, weights, and positions.

13 Dec, 2022 | 14:14h | UTC

Chest wall loading in the ICU: pushes, weights, and positions – Annals of Intensive Care

 


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