All Posts
M-A | Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients
9 Feb, 2023 | 13:24h | UTC
M-A | Comparative antiseizure medications for adjunctive treatment in children with drug-resistant focal-onset seizures
9 Feb, 2023 | 13:22h | UTC
Retrospective Cohort | Survivors of sepsis are at increased risk of late cardiovascular events
8 Feb, 2023 | 12:46h | UTCNews Release: Sepsis increased risk of heart failure and rehospitalization after hospital discharge – American Heart Association
Commentaries:
Sepsis Emerges as Powerful CVD Risk Factor in Large US Analysis – TCTMD
Cardiovascular Hospitalization Increased After Sepsis Hospitalization – HealthDay
Spinal cord injury: the global incidence, prevalence, and disability from the Global Burden of Disease Study 2019
9 Feb, 2023 | 13:20h | UTCCommentary: Measures needed to combat growing incidence and burden of spinal cord injury – Spinal News International
RCT | Gefitinib plus MTX not better than MTX alone to treat tubal ectopic pregnancy
8 Feb, 2023 | 12:43h | UTC
Commentary from the author on Twitter (thread – click for more)
See our @Gem3Study in @TheLancet: no benefit of adding gefitinib to methotrexate to treat #ectopic pregnancy but important data to inform guidelines on clinical outcomes after methotrexate https://t.co/xgtA4oLBJd @ProfStephenTong @GynaeResearcher @TheEPT @MRC_CRH @EdinUniMedia pic.twitter.com/g96Z8B400a
— Andrew Horne (@horne_research) February 2, 2023
Under a Creative Commons Attribution (CC BY 4.0) license
Review | Liberation from mechanical ventilation in the cardiac intensive care unit
8 Feb, 2023 | 12:45h | UTCLiberation From Mechanical Ventilation in the Cardiac Intensive Care Unit – JACC: Advances
Review | Management of menopausal symptoms
8 Feb, 2023 | 12:44h | UTCManagement of Menopausal Symptoms: A Review – JAMA (free for a limited period)
Audio Clinical Review: Treatment of Menopausal Symptoms – JAMA
RCT | Methylprednisolone vs. immunoglobulins equally effective in PIMS temporally associated with SARS-CoV-2
8 Feb, 2023 | 12:42h | UTC
Review | Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome
8 Feb, 2023 | 12:38h | UTC
Commentary on Twitter
In our latest Comment, Fedorowski & Sutton discuss the role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute #COVID19 syndrome: https://t.co/gJ08XxnfQ6 pic.twitter.com/FmC9JwDs4C
— Nature Reviews Cardiology (@NatRevCardiol) February 2, 2023
Video | Malaria — Epidemiology, treatment, and prevention
8 Feb, 2023 | 12:37h | UTCMalaria — Epidemiology, Treatment, and Prevention | NEJM
Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods
8 Feb, 2023 | 12:36h | UTCAd libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)
News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas
Commentary from one of the authors on Twitter (thread – click for more)
What determines how many calories people eat during a meal? Our new study, led by Tera Fazzino @UnivOfKansas, was just published in @NatureFoodJnl & investigated the meal characteristics that influence ad libitum energy intake. https://t.co/Of2IzddLRd
— Kevin Hall (@KevinH_PhD) January 30, 2023
RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy
8 Feb, 2023 | 12:32h | UTCOutcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Crossover RCT | Effects of SGLT2 inhibition on sodium in patients with chronic syndrome of inappropriate antidiuresis
8 Feb, 2023 | 12:34h | UTC
Commentary on Twitter
The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study shows the SGLT2 inhibitor empagliflozin is a promising new treatment for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function https://t.co/U26RNmVM9j pic.twitter.com/8pH6xqSs7D
— JASN_News (@JASN_News) December 12, 2022
Guideline | Management of anterior cruciate ligament injuries
8 Feb, 2023 | 12:31h | UTCRelated:
M-A | Primary surgery vs. primary rehabilitation for treating anterior cruciate ligament injuries.
A Majority of Anterior Cruciate Ligament Injuries Can Be Prevented by Injury Prevention Programs: A Systematic Review of Randomized Controlled Trials and Cluster–Randomized Controlled Trials With Meta-analysis – American Journal of Sports Medicine (link to abstract – $ for full-text)
Guideline on rehabilitation after anterior cruciate ligament reconstruction
8 Feb, 2023 | 12:30h | UTCGuideline: Management of Anterior Cruciate Ligament Injuries Evidence-Based Clinical Practice Guideline
Commentary on Twitter
What are the components of #rehabilitation after #ACLR? Clinical practice #guideline based on 140 RCTs and agreement by 29 expert clinicians.
Open access 🔓 https://t.co/cnLpV0rzgG#Recommendations 👇👇 pic.twitter.com/Lyxuz5tVZE— Roula Kotsifaki (@RoulaKotsifaki) February 3, 2023
A decision guide for assessing the recently extubated patient’s readiness for safe oral intake
8 Feb, 2023 | 12:28h | UTC
Review | Pyoderma gangrenosum: Established and emerging pharmacological treatments
8 Feb, 2023 | 12:27h | UTC
M-A | Needle-free pharmacological sedation techniques in pediatric patients for imaging procedures
8 Feb, 2023 | 12:26h | UTC
52-week results from two phase III trials of brolucizumab for diabetic macular edema
8 Feb, 2023 | 12:25h | UTC
M-A | Intranasal midazolam vs. intranasal ketamine as sedative premedication in pediatric patients
8 Feb, 2023 | 12:24h | UTC
Phase 1b RCT | Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia
8 Feb, 2023 | 12:23h | UTCEmraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial – The Lancet (link to abstract – $ for full-text)
Commentary: Emraclidine is safe and well-tolerated for the treatment of schizophrenia – 2 Minute Medicine
Commentary on Twitter (thread – click for more)
Up to 1/3 of patients with #schizophrenia do not respond to current treatments, and there remains a need for novel approaches that balance efficacy against side-effects.
This phase 1b study assessed the safety and tolerability of emraclidine 🧵 https://t.co/WMcArqDK1C
— The Lancet (@TheLancet) December 28, 2022
Phase 2b RCT | An anti-OX40 antibody to treat moderate-to-severe atopic dermatitis
8 Feb, 2023 | 12:22h | UTCAn anti-OX40 antibody to treat moderate-to-severe atopic dermatitis: a multicentre, double-blind, placebo-controlled phase 2b study – The Lancet (link to abstract – $ for full-text)
News Release: New Treatment for Moderate to Severe Atopic Dermatitis Shows Promising Long-Term Results – Mount Sinai Health System
Commentary: Rocatinlimab Effective for Moderate-to-Severe Atopic Dermatitis – HealthDay
Commentary on Twitter:
Just published in The Lancet: Patients treated w- rocatinlimab, an anti-OX40 antibody, had progressive improvements in atopic dermatitis, which was maintained in most pts after treatment stopped. @EmmaGuttman PI. Details: https://t.co/PpiKsy0ra0 pic.twitter.com/6ghKpsLQsZ
— Mount Sinai Dermatology (@MSHSDerm) December 10, 2022
M-A | Risk of endometrial cancer in postmenopausal women in relation to ultrasonographic endometrial thickness
8 Feb, 2023 | 12:21h | UTCRisk of endometrial cancer in asymptomatic postmenopausal women in relation to ultrasonographic endometrial thickness: systematic review and diagnostic test accuracy meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Commentary on Twitter
AJOG Systematic Review: Risk of endometrial cancer in asymptomatic postmenopausal women in relation to ultrasonographic endometrial thickness: systematic review and diagnostic test accuracy meta-analysis https://t.co/uxPx8Jr160 pic.twitter.com/LugkrnKmjr
— AJOG (@AJOG_thegray) December 30, 2022
Review | Perioperative cardiovascular pathophysiology in patients undergoing lung resection surgery
8 Feb, 2023 | 12:19h | UTC
Review | Advanced diagnostic and therapeutic techniques for anesthetists in thoracic trauma
8 Feb, 2023 | 12:18h | UTC