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“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest

21 Jul, 2017 | 17:46h | UTC

The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

The Aging Physician and the Medical Profession: A Review

21 Jul, 2017 | 00:25h | UTC

The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)

Hepatology: Five Things Physicians and Patients Should Question

21 Jul, 2017 | 00:26h | UTC

New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock

21 Jul, 2017 | 17:38h | UTC

An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)

Fri, July 21 – 10 Stories of The Day!

21 Jul, 2017 | 02:46h | UTC

1 – Report: HIV drug resistance report 2017 – World Health Organization (free)

News release: WHO urges action against HIV drug resistance threat (free)

Commentaries: HIV drug resistance could undermine progress in AIDS battle: WHO – Reuters (free) AND Drug-Resistant HIV Is On the Rise – TIME (free)

2 – Report: Ending AIDS: Progress Towards the 90-90-90 Target – Joint United Nations Programme on HIV/AIDS (UNAIDS) (free PDF)

Fact Sheet: Latest Statistics on The Status of The Aids Epidemic – UNAIDS (free) (RT @greg_folkers see Tweet)

Commentary: For first time in history, half of all people with HIV are getting treatment – Science (free) (source: GlobalHealthNOW newsletter)

3 – Parkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)

4 – Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

5 – Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)

6 – Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials – The BMJ (free)

Editorial: Diet and exercise in pregnancy (free)

Commentaries: Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds – NewsMedical (free) AND C-Section Risk Reduction Linked to Healthy Lifestyle – MedPage Today (free)

7 – The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

8 – Report: Dementia prevention, intervention, and care – The Lancet (free registration required)

Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)

9 – The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

10 – An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)

Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target

21 Jul, 2017 | 00:23h | UTC

Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)

Community-associated methicillin-resistant Staphylococcus aureus infection

21 Jul, 2017 | 00:24h | UTC

Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)

Efficacy and Safety of Spironolactone in Acute Heart Failure

21 Jul, 2017 | 00:21h | UTC

Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)

Use of antibiotics during pregnancy and the risk of major congenital malformations

21 Jul, 2017 | 00:22h | UTC

Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

In this large cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

WHO report on the global tobacco epidemic 2017

21 Jul, 2017 | 00:19h | UTC

WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

Commentaries: Taxation: Most effective but still the least-used tobacco control measure, by Patricio V. Marquez via The World Bank Blogs (free) AND Tobacco industry blocking anti-smoking moves: WHO – Reuters (free) AND Tobacco firms ‘hamper anti-smoking push’ – BBC News (free) AND Tobacco companies interfere with health regulations, WHO reports – The Guardian (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).

American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs

21 Jul, 2017 | 00:23h | UTC

Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)

Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease

20 Jul, 2017 | 00:13h | UTC

Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)

USPSTF Draft Recommendation Statement on Ovarian Cancer Screening

20 Jul, 2017 | 00:10h | UTC

Draft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)

Thu, July 20 – 10 Stories of The Day!

20 Jul, 2017 | 02:10h | UTC

1 – WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).

2 – Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.

3 – Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

4 – Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

In this large canadian cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

5 – Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

6 – Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)

7 – Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)

8 – The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)

9 – New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

10 – Improving people’s health through spatial planning – Public Health England (free) (RT @pash22 see Tweet)

Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection

21 Jul, 2017 | 00:20h | UTC

Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.

Emerging arboviruses: Why today?

20 Jul, 2017 | 00:09h | UTC

Review: Emerging arboviruses: Why today? – One Health (free) (RT @greg_folkers see Tweet)

New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

20 Jul, 2017 | 00:07h | UTC

Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

Association Between Vasectomy and Prostate Cancer

20 Jul, 2017 | 00:11h | UTC

The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-Analysis: Vasectomy Likely Does Not Cause Prostate Cancer – Physician’s First Watch (free) AND Weak Link Between Vasectomy, Prostate Cancer – MedPage Today (free registration required)

Oral antifungal medication for toenail onychomycosis

20 Jul, 2017 | 00:08h | UTC

Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

Practice guidelines for management of uterine corpus cancer

18 Jul, 2017 | 23:14h | UTC

Practice guidelines for management of uterine corpus cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement (free)

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