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Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

2 – Latest European Society of Cardiology Clinical Practice Guidelines Summary Cards are now available (Atrial Fibrillation, Heart Failure, CVD Prevention, Cardio-Oncology – free PDF summaries).

See Complete list:

– Atrial Fibrillation

– Heart Failure

– European CVD Prevention in Clinical Practice

– Cardio-oncology

– Infective Endocarditis

– Hypertrophic Cardiomyopathy

– Cardiac Pacing & CRT

– Arterial Hypertension

– Diabetes & Pre-Diabetes, CVD

– Valvular Heart Disease

3 – Public health interventions may offer society a return on investment of £14 for each £1 spent – NIHR Signal (free)

Original article: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Community Health (free)

4 – Viewpoint: Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors – JAMA (free)

Balanced point of view regarding the use of PCSK9 Inhibitors.

5 – Update on pediatric sepsis: a review – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter

6 – Richard Lehman’s journal review, 24 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

7 – Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

8 – Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first. Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

9 – Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient (free)

10 – Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma (free)

Tai Chi for Risk of Falls. A Meta-analysis

24 Jul, 2017 | 23:41h | UTC

Tai Chi for Risk of Falls. A Meta-analysis – Journal of The American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Tai chi may help prevent falls in older and at-risk adults – Wiley, via EurekAlert (free) AND Meta-Analysis: Tai Chi May Reduce Fall Risk in Older Adults – Physician’s First Watch (free)

Review: Update on pediatric sepsis

25 Jul, 2017 | 00:03h | UTC

Update on pediatric sepsis: a review – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter

WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection

24 Jul, 2017 | 01:03h | UTC

WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) (RT @equitylist see Tweet)

Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

See also: WHO’s Work on Pre-exposure prophylaxis (free resources)

Review: Organ dysfunction, injury and failure in acute heart failure

24 Jul, 2017 | 01:02h | UTC

Review: Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (free)

Why are doctors plagued by depression and suicide?

25 Jul, 2017 | 00:09h | UTC

Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy

24 Jul, 2017 | 01:04h | UTC

Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy – World Health Organization (free) (RT @greg_folkers see Tweet with infographic)

Why cancer is not a war, fight, or battle

24 Jul, 2017 | 01:00h | UTC

Why cancer is not a war, fight, or battle – CNN (free)

Related: He’s a Fighter – The Atlantic (free)

“Cancer is a process, it’s not a war. No winners or losers. Stop military metaphors”. (RT @lucadf see Tweet)

Effects of NOACs Versus Warfarin in Patients With AF and Valvular Heart Disease

24 Jul, 2017 | 00:58h | UTC

Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis – Journal of The American Heart Association (free)

“Among patients with AF and native VHD, NOACs reduce stroke and systemic embolism compared with warfarin”.

Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile

24 Jul, 2017 | 01:01h | UTC

Effects of control interventions on Clostridium difficile infection in England: an observational study – The Lancet Infectious Diseases (free)

Invited Commentary: Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile (free)

“Very important finding! Restricting fluoroquinolones more important than infection control measures to prevent CDI” (RT @sanjaysaint see Tweet)

Mon, July 24 – 10 Stories of The Day!

24 Jul, 2017 | 00:33h | UTC

1 – Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy – World Health Organization (free) (RT @greg_folkers see Tweet with infographic)

2 – WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) (RT @equitylist see Tweet)

Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

See also: WHO’s Work on Pre-exposure prophylaxis (free resources)

3 – Review: Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (free)

4 – Effects of control interventions on Clostridium difficile infection in England: an observational study – The Lancet Infectious Diseases (free)

Invited Commentary: Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile (free)

“Very important finding! Restricting fluoroquinolones more important than infection control measures to prevent CDI” (RT @sanjaysaint see Tweet)

5 – Why cancer is not a war, fight, or battle – CNN (free)

Related: He’s a Fighter – The Atlantic (free)

“Cancer is a process, it’s not a war. No winners or losers. Stop military metaphors”. (RT @lucadf see Tweet)

6 – “A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

7 – Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis – Journal of The American Heart Association (free)

“Among patients with AF and native VHD, NOACs reduce stroke and systemic embolism compared with warfarin”.

8 – High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies – Diabetic Medicine (link to abstract – $ for full-text)

Commentary: Screening for Erectile Dysfunction Should Be Routine in Diabetes – Medscape (free registration required)

“Erectile dysfunction 3.5 times more common in diabetes” (RT @kamleshkhunti see Tweet)

9 – Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)

10 – The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

High prevalence of erectile dysfunction in diabetes

24 Jul, 2017 | 00:56h | UTC

High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies – Diabetic Medicine (link to abstract – $ for full-text)

Commentary: Screening for Erectile Dysfunction Should Be Routine in Diabetes – Medscape (free registration required)

“Erectile dysfunction 3.5 times more common in diabetes” (RT @kamleshkhunti see Tweet)

NHS to end prescription of homeopathic remedies

24 Jul, 2017 | 01:00h | UTC

“A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

24 Jul, 2017 | 00:55h | UTC

Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)

Free Online Course: Systems Thinking In Public Health

24 Jul, 2017 | 00:27h | UTC

Starts Today! Free Online Course: Systems Thinking In Public Health – Johns Hopkins University and Coursera

“Problems in public health and health policy tend to be complex with many actors, institutions and risk factors involved. If an outcome depends on many interacting and adaptive parts and actors the outcome cannot be analyzed or predicted with traditional statistical methods. Systems thinking is a core skill in public health and helps health policymakers build programs and policies that are aware of and prepared for unintended consequences”.

Richard Lehman’s journal review – 24 July 2017

Enhanced recovery pathway for colorectal surgical patients improves outcomes, reduces cost

Psychosis relapse, medication non-adherence, and cannabis

Amyloid PET for Mild Cognitive Impairment Diagnosis

New Long-Acting Injectable HIV Therapies

The Population Health Benefits Of A Healthy Lifestyle

Tue, July 25 – 10 Stories of The Day!