All Posts
M-A | Financial toxicity among patients with breast cancer worldwide
17 Feb, 2023 | 13:20h | UTCCommentary: Breast Cancer Treatment Is Associated With Financial Toxicity Worldwide, Study Finds – AJMC
Related:
Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR
Financial Toxicity and Cancer Treatment (PDQ®) – National Institute of Cancer
Commentary on Twitter
Financial toxicity for patients with breast cancer (pooled): 78% in LMICs and 35% in HICs; much higher than other health conditions, including other cancers. Policies to address this huge burden are critical to improve financial and health outcomes. https://t.co/eaB7nCvurU
— JAMA Network Open (@JAMANetworkOpen) February 9, 2023
M-A | Aspirin with or without statin in individuals without atherosclerotic CVD across risk categories
17 Feb, 2023 | 13:22h | UTCSummary: This meta-analysis examined the effects of aspirin in adults without atherosclerotic cardiovascular disease (ASCVD), stratified by statin use across different ASCVD risks. The analysis found that aspirin reduced myocardial infarction but increased major bleeding, and was not associated with total or cardiovascular survival benefits. In adults without ASCVD, concomitant statin appeared to significantly reduce absolute risk reduction for MI associated with aspirin without influencing bleeding risk. The study highlights that the risk-benefit equilibrium may be tilted towards more harm for primary prevention, and that the expected absolute risk of major bleeding exceeds absolute MI benefits by aspirin for every level of ASCVD risk. The findings have implications for the use of aspirin in those already on statin therapy for primary ASCVD prevention.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Consensus Paper | Pediatric traumatic hemorrhagic shock
17 Feb, 2023 | 13:15h | UTCPreface: Pediatric traumatic hemorrhagic shock consensus conference
Other articles in the supplement:
Pediatric traumatic hemorrhagic shock consensus conference research priorities
Building an optimal pediatric trauma program
Time is tissue: Barriers to timely transfusion after pediatric injury
Resuscitative practices and the use of low-titer group O whole blood in pediatric trauma
Tranexamic acid in pediatric hemorrhagic trauma
Blood banking considerations in pediatric trauma
Detecting traumatic brain injury–induced coagulopathy: What we are testing and what we are not
Perspective | Choosing the right path toward polio eradication
17 Feb, 2023 | 13:18h | UTCChoosing the Right Path toward Polio Eradication – New England Journal of Medicine
Post hoc analysis | Prevalence and significance of bradyarrhythmias in patients screened for atrial fibrillation
17 Feb, 2023 | 13:13h | UTCSummary: This study looked at the prevalence and significance of bradyarrhythmias in people screened for atrial fibrillation using an implantable loop recorder compared to those who did not receive screening. The study found that screening was associated with the incidental diagnosis of bradyarrhythmias in 1 in 5 people and an increase in pacemaker implantations, but it did not reduce the risk of syncope or sudden death. While bradyarrhythmias are common in older people and can be risk markers, actively detecting and treating them in asymptomatic individuals may not improve clinical outcomes.*
Author Interview: Prevalence and Prognostic Significance of Bradyarrhythmias in Patients Screened for Atrial Fibrillation vs Usual Care – JAMA
Commentary on Twitter
In the randomized LOOP study, AF screening resulted in the coincidental diagnosis of sinus node dysfunction or atrioventricular block in 1 of 5 participants, along with increased pacemaker implantations, but no change in risk of syncope or sudden death. https://t.co/V5JK2iGlQV
— JAMA Cardiology (@JAMACardio) February 15, 2023
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Updated Guideline | Management of hip fracture
17 Feb, 2023 | 13:17h | UTCHip fracture: management – National Institute for Health and Care Management
Quality Standard: Hip fracture in adults – National Institute for Health and Care Management
Retrospective Cohort | High burden of premature ventricular complex linked to increased risk of new‐onset atrial fibrillation
17 Feb, 2023 | 13:12h | UTCSummary: The study investigated whether a high burden of premature ventricular complex (PVC) is associated with an increased risk of new-onset atrial fibrillation (AF). The study analyzed the daily burden of PVC using the 24-hour Holter ECG and medical record databases of a single hospital in Taiwan. Patients with high PVC burden were at a higher risk of new-onset AF compared to those with low PVC burden.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
RCT | Effect of non-invasive ventilation after extubation in critically ill patients with obesity
17 Feb, 2023 | 13:10h | UTCEffect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Among critically ill adults with obesity undergoing extubation, the use of NIV was effective to reduce treatment-failure within 3 days
Read the RCT from Audrey De Jong & colleagues here: https://t.co/nMB3W8NAYX #SCCM2023 pic.twitter.com/iEHExPEhSN
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
M-A | Efficacy and safety of drugs for gastroparesis
17 Feb, 2023 | 13:05h | UTCCommentaries:
Review finds only two efficacious medications to treat gastroparesis – ACP Gastroenterology
Two drug classes appear effective for gastroparesis treatment – MDedge
Commentary from the author on Twitter (thread – click for more)
Our latest (and definitely last!) paper of 2022 is now published online in @AGA_Gastro and is a network meta-analysis of drugs in gastroparesis:https://t.co/kpz8nH6ekT
— Alexander Ford (@alex_ford12399) December 26, 2022
RCT | Effect of early mobilization on long-term cognitive impairment in critical illness
17 Feb, 2023 | 13:07h | UTCEffect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)
Related:
M-A | The effect of early active mobilization at 6 months after critical illness
Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—Early mobilisation might improve long-term cognitive impairment in ICU survivors after MV, but the increased risk of adverse events in the intervention group should be noted
Read the RCT from Bhakti Patel & colleagues here: https://t.co/DeqraodGXq #SCCM2023 pic.twitter.com/RMDhE7UxPM
— The Lancet Respiratory Medicine (@LancetRespirMed) January 21, 2023
Review | Contemporary pharmacotherapies for nontuberculosis mycobacterial infections
17 Feb, 2023 | 13:03h | UTC
M-A | Catheter directed thrombolysis for not immediately threatened acute limb ischemia
17 Feb, 2023 | 13:00h | UTC
M-A | Foot orthoses for flexible flatfeet in children and adults
17 Feb, 2023 | 13:02h | UTC
M-A | Global status of azithromycin and erythromycin resistance rates in Neisseria gonorrhoeae
17 Feb, 2023 | 12:58h | UTC
Retrospective Cohort | Lifetime risk of comorbidity in patients with simple congenital heart disease
17 Feb, 2023 | 12:57h | UTC
Commentary on Twitter
Lifetime risk of comorbidity in patients with simple congenital heart disease: a Danish nationwide study https://t.co/r8WDeL5Ra5 @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/llrApfl2xR
— European Society of Cardiology Journals (@ESC_Journals) December 14, 2022
M-A | The rate and assessment of muscle wasting during critical illness
17 Feb, 2023 | 12:55h | UTC
Commentary on Twitter
A Review published in @Crit_Care analyzes the data of ICU muscle wasting studies and reports that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.https://t.co/qW5jzbWRSk
— BMC (@BioMedCentral) January 8, 2023
Case Reports | Seventeen cases of daptomycin-induced eosinophilic pneumonia in bone and joint infections
17 Feb, 2023 | 12:54h | UTC
SR | Antipsychotic exposure is an independent risk factor for breast cancer
17 Feb, 2023 | 12:41h | UTC
RCT | Home high-flow nasal cannula oxygen therapy for stable hypercapnic COPD
17 Feb, 2023 | 12:53h | UTC
Acute pain management pearls: a focused review for the hospital clinician
17 Feb, 2023 | 12:42h | UTCAcute Pain Management Pearls: A Focused Review for the Hospital Clinician – Healthcare
Review | Perioperative optimization of Crohn’s disease
17 Feb, 2023 | 12:39h | UTCPerioperative optimization of Crohn’s disease – Annals of Gastroenterological Surgery
Review | Integrating geriatric assessment and prehabilitation into surgical practice can improve outcomes for GI cancer patients with frailty
17 Feb, 2023 | 12:37h | UTC
Current status of liver transplantation for non-B non-C liver cirrhosis and hepatocellular carcinoma
17 Feb, 2023 | 12:36h | UTC
M-A | Association between antimicrobial stewardship programs and antibiotic use globally
16 Feb, 2023 | 15:21h | UTCCommentaries:
Antimicrobial Stewardship Programs Beneficial for Cutting Antibiotic Use – HealthDay
RCT | Rivaroxaban shows promise compared to Enoxaparin in the acute phase of an acute coronary syndrome
16 Feb, 2023 | 15:20h | UTCInvited Commentary: Rivaroxaban for Patients With Acute Coronary Syndromes—Where Do We Stand? – JAMA Network Open
Commentary on Twitter
The H-REPLACE RCT: short-term rivaroxaban (5mg 2x/day) was noninferior to enoxaparin in safety + efficacy during 6-month follow-up among patients with acute coronary syndrome who missed the primary reperfusion window and before selective revascularization. https://t.co/TIHOwGSWjJ
— JAMA Network Open (@JAMANetworkOpen) February 10, 2023