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Review: When Psychiatric Symptoms Reflect Medical Conditions

22 Feb, 2018 | 21:47h | UTC

When psychiatric symptoms reflect medical conditions – Journal of Emergency and Critical Care Medicine (free)

Source: Critical Care Reviews Newsletter

EBM: All Fair Comparisons and Outcomes Should be Reported

22 Feb, 2018 | 21:45h | UTC

All fair comparisons and outcomes should be reported – Students 4 Best Evidence (free)

Review: A Systematic Approach to the Unconscious Patient

22 Feb, 2018 | 21:43h | UTC

A systematic approach to the unconscious patient – Clinical Medicine (free)

Source: Critical Care Reviews Newsletter

Review: Thrombotic Microangiopathy and the Kidney

22 Feb, 2018 | 21:46h | UTC

Thrombotic Microangiopathy and the Kidney – Clinical Journal of the American Society of Nephrology (free)

Source: Critical Care Reviews Newsletter

Research: Probiotics in Young Patients With Moderate Atopic Dermatitis

22 Feb, 2018 | 21:41h | UTC

Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Probiotics may improve pediatric AD symptoms – DermatologyTimes (free) AND Probiotics May Improve Pediatric AD Symptoms – MedPage Today (free registration required)

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants

22 Feb, 2018 | 21:42h | UTC

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants – Canadian Medical Association Journal (free)

Commentaries: Cracks in the code: Why mapping your DNA may be less reliable than you think – The Globe and Mail (free) AND Genomics has entered its adolescent phase: messy and unpredictable – The Globe and Mail (free) AND University of Toronto News (free)

Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years

22 Feb, 2018 | 21:44h | UTC

Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years – The Lancet Global Health (free)

Invited Commentary: Exploring the broader consequences of diarrhoeal diseases on child health (free)

Review: Legal and Practical Issues at the End of Life

22 Feb, 2018 | 21:38h | UTC

Legal and practical issues at the end of life – Clinical Medicine (free)

Source: Critical Care Reviews Newsletter

Review: Integration of Bedside Ultrasound into the ICU

22 Feb, 2018 | 21:39h | UTC

Integration of bedside ultrasound into the ICU—a review of indications, techniques and interventions – Journal of Emergency and Critical Care Medicine (free)

Source: Critical Care Reviews Newsletter

Updates in Palliative Care – Recent Advancements in the Pharmacological Management of Symptoms

22 Feb, 2018 | 21:36h | UTC

Updates in palliative care – recent advancements in the pharmacological management of symptoms – Clinical Medicine (free)

Source: Critical Care Reviews Newsletter

Review: Respiratory Viruses in Transplant Recipients

22 Feb, 2018 | 21:34h | UTC

Respiratory viruses in transplant recipients: more than just a cold. Clinical syndromes and infection prevention principles – International Journal of Infectious Diseases (free)

Updates in Palliative Care – Overview and Recent Advancements in the Pharmacological Management of Cancer Pain

22 Feb, 2018 | 21:37h | UTC

Updates in palliative care – overview and recent advancements in the pharmacological management of cancer pain – Clinical Medicine (free)

Source: Critical Care Reviews Newsletter

Expert: Antibiotic use may be tied to rise in ‘lifestyle’ diseases

22 Feb, 2018 | 21:33h | UTC

Expert Opinion: Expert: Antibiotic use may be tied to rise in ‘lifestyle’ diseases – CIDRAP (free)

Thu, February 22 – 10 Stories of The Day!

22 Feb, 2018 | 02:09h | UTC

1 – Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)

“Among patients who received 5 days of rivaroxaban prophylaxis after total hip or total knee arthroplasty, extended prophylaxis with aspirin was not significantly different from rivaroxaban in the prevention of symptomatic venous thromboembolism”.

2 – Guideline: Peripheral arterial disease: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

3 – Guideline: Heavy menstrual bleeding: assessment and management – National Institute for Health and Care Excellence (NICE) (free)

4 – Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Related AHA Scientific Statement: Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science (free)

5 – Are you ready for the ATLS 10th Edition Updates? – emDocs (free)

Related: Infographic: ATLS Trauma Update 2018

6 – Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care – The BMJ (free)

Commentaries: Anticoagulants Tied With Stroke, Hemorrhage in CKD – Renal & Urology News (free) AND Could a Blood Thinner Actually Raise Stroke Risk for Some? – HealthDay (free) AND Anticoagulants for Patients with Afib and Kidney Disease? Study Yields Mixed Findings – Physician’s First Watch (free) AND Blood-thinning drugs designed to cut stroke risk may actually increase it – The Guardian (free)

“Given the lack of guidelines, the decision to start anticoagulant treatment in patients with chronic kidney disease and new onset atrial fibrillation should be made on an individual basis, concludes research” (via @bmj_latest see Tweet)

6 – Current concepts of fluid management in enhanced recovery pathways – British Journal of Anaesthesia (free)

See other Enhanced Recovery After Surgery Guidelines and Reviews

7 – Association of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population – JAMA Internal Medicine (free for a limited period)

Commentaries: Cigars and pipes tied to same risks as cigarettes – Reuters (free) AND Cigars and pipes raise mortality risk independent of cigarettes – OnMedica (free)

8 – It’s poverty, not individual choice, that is driving extraordinary obesity level – The Conversation (free)

“Statistics point remorselessly towards obesity being a symptom with an underlying social cause”.

9 – Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials – The BMJ (free)

Among patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography, without apparent impact on the future risk of myocardial infarction. Similarly, for outpatients with suspected stable angina, an initial strategy based on functional testing might be preferable, resulting in fewer referrals for invasive coronary angiography and revascularization, without a statistically significant difference in the future risk of MI.

10 – Maternal thyroid function and child educational attainment: prospective cohort study – The BMJ (free)

Related study and commentary: Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy – New England Journal of Medicine (free) AND Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free)

Maternal thyroid dysfunction in the first trimester had no impact on child performance at school or educational achievement.

Mon, February 19 – 10 Stories of The Day!

19 Feb, 2018 | 00:01h | UTC

1 – Haemodynamic assessment and support in sepsis and septic shock in resource-limited settings – Transactions of The Royal Society of Tropical Medicine and Hygiene (free)

Source: Critical Care Reviews Newsletter

2 – Simplified guideline for prescribing medical cannabinoids in primary care – Canadian Family Physician (free)

Commentary: New guideline warns pain benefits of medical cannabis overstated – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free)

3 – Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Aggressive Systolic Blood Pressure Control In Older Patients With HFpEF Should Be Avoided – MedicalResearch.com (free) AND Low blood pressure linked to worse outcomes in HFpEF patients – Cardiovascular Business (free)

“A systolic blood pressure level of less than 120 mm Hg identifies patients with heart failure with preserved ejection fraction at higher risk for short- and long-term mortality and emphasizes the need for future prospective studies to evaluate optimal systolic blood pressure treatment goals in this patient population”.

4 – Editorial: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free)

5 – Interim Estimates of 2017–18 Seasonal Influenza Vaccine Effectiveness — United States, February 2018 – MMWR, Centers for Disease Control and Prevention (free)

Commentaries: US study finds 36% flu vaccine protection, 25% against H3N2 – CIDRAP (free) AND Three-quarters of people who got flu shot this year weren’t protected against most common strain – STAT (free)

6 – Review: Delirium in the Cardiac Intensive Care Unit – Journal of the American Heart Association (free for a limited period)

Source: Critical Care Reviews Newsletter

7 – New Choosing Wisely Lists in Pediatrics: Four Things Physicians and Patients Should Question in Pediatric Infectious Diseases and Medical Microbiology – Choosing Wisely Canada (free) AND Five Things Physicians and Patients Should Question in Pediatric Orthopedics – Choosing Wisely U.S. (free)

See complete lists from Choosing Wisely U.S., Choosing Wisely UK, Choosing Wisely Australia AND Choosing Wisely Canada

8 – Expert opinion: ‘UTI’ an overused diagnosis in the era of the microbiome – ACP Hospitalist (free)

9- Technology: Wanted: a WhatsApp alternative for clinicians – The BMJ Opinion (free)

10 – Breast Biopsy Intensity and Findings Following Breast Cancer Screening in Women With and Without a Personal History of Breast Cancer – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Breast MRIs may lead to more biopsies that catch fewer cancers – Reuters (free) AND MRI-Based Breast Screening Leads to More Biopsies, Lower Cancer Yields – Physician’s First Watch (free)

Wed, February 21 – 10 Stories of The Day!

21 Feb, 2018 | 01:20h | UTC

1 – Clinical Guidelines Synopsis: Management of ARDS in Adults – JAMA (free)

2 – Clinical recommendations for high altitude exposure of individuals with pre-existing cardiovascular conditions – European Heart Journal (free)

Commentaries: European experts release guidelines about high-altitude exposure for cardiovascular patients – Cardiovascular Business (free) AND A trip to the mountains despite a heart condition? – Eurac Research, via ScienceDaily (free)

3 – Contribution of alcohol use disorders to the burden of dementia in France 2008–13: a nationwide retrospective cohort study – The Lancet Public Health (free)

Commentaries: Alcohol and dementia: a complex relationship with potential for dementia prevention – The Lancet Public Health (free) AND Expert reaction to study looking at alcohol use disorders and dementia risk – Science Media Centre (free) AND Heavy Drinking Tied to Early-Onset Dementia in French Study – MedPage Today (free registration required)

“Of 57,000 people diagnosed before age 65 with early-onset dementia, 39% had alcohol-related dementia by definition, and 18% had an additional diagnosis of alcohol use disorders” (via @medpagetoday see Tweet)

4 – Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Low-Carb And Low-Fat Diets Battle To A Draw – Cardiobrief (free) AND Matching DNA to a diet doesn’t work: ‘We didn’t even come close,’ researcher says – STAT (free) AND Counting Calories Is Not the Key to Weight Loss, New Study Finds – The New York Times (10 articles per month are free) AND Debating low-fat vs low-carb diets? New study found a draw – Scope (free)

5 – Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial – JAMA (free)

Prophylactic haloperidol in this population with elevated risk of delirium did not reduce mortality or any of the 15 prespecified secondary outcomes, including delirium incidence, 28-day delirium-free and coma-free days, duration of mechanical ventilation, and ICU and hospital length of stay.

6 – Review: Adverse pregnancy outcomes and future maternal cardiovascular disease – Clinical Cardiology (free)

7 – Update on Diabetic Nephropathy: Core Curriculum 2018 – American Journal of Kidney Diseases (free)

8 – Avoid common mistakes when treating hyponatremia – ACP Hospitalist (free)

9 – Analysis: How many lives are at stake? Assessing 2030 sustainable development goal trajectories for maternal and child health – The BMJ (free)

10 – Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

The mean number of hypoglycemic events per 28 days was reduced from 10.8 to 3.5 among patients in the continuous glucose monitoring group and from 14.4 to 13.7 among control group participants.

Guidelines for Clostridium difficile Infection in Adults and Children

16 Feb, 2018 | 02:33h | UTC

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) (free)

Commentary: Fecal transplants move into the mainstream to treat difficult infection – STAT (free)

Tue, February 20 – 10 Stories of The Day!

20 Feb, 2018 | 01:28h | UTC

1 – Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update – Annals of Internal Medicine (free)

2 – Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain – American College of Physicians, via EurekAlert (free)

3 – Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation – British Journal of Anaesthesia (free)

4 – Short-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients: A Meta-Analysis of Individual Participant Data From 6 Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentary: Dual Antiplatelet Therapy Duration in Elderly Patients – American College of Cardiology, Latest in Cardiology (free)

Short-term Dual Antiplatelet Therapy was not associated with increased risk of ischemic events in elderly patients and was associated with a significant reduction in major bleeding.

5 – British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma – Thorax (free)

6 – Opinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea – HealthNewsReview (free)

“The review confirms small benefits on symptom relief, namely shortening duration of symptoms by half a day on average. However, there is little evidence to support any belief that use of NIs reduces hospital admission or the risk of developing confirmed pneumonia”. (from Cochrane)

7 – Risk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis – Diseases of the Colon and Rectum (link to abstract – $ for full-text)

Commentary: Which Patients with Diverticulitis Require Surgery? – Diseases of the Colon & Rectum, via NewsWise (free)

In this large cohort of 65,162 patients identified with a first episode of acute diverticulitis, younger patients, women, smokers, obese individuals, and those who had diverticulitis with perforation and/or abscess were more likely to develop recurrent diverticulitis.

8 – Richard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

9 – Review: Anaphylaxis – Chest (free)

Source: Critical Care Reviews Newsletter

10 – Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study – Open Forum Infectious Diseases (free)

“Aside from the rare extra-pulmonary manifestations of mycoplasma (e.g., rashes, hemolysis, neurologic complications), do any of the many causes of pneumonia have distinctive clinical presentations? Probably not”. (via @PaulSaxMD see Tweet)

Research: Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine

16 Feb, 2018 | 02:32h | UTC

Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography: The PRESERVE trial – 2 Minute Medicine (free) AND Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – NEJM Resident 360 (free)

“Among patients at high risk for renal complications who were undergoing angiography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over placebo for the prevention of death, need for dialysis, or persistent decline in kidney function at 90 days or for the prevention of contrast-associated acute kidney injury”.