All Posts
Review: Neoplastic meningitis in solid tumors
22 Mar, 2018 | 23:32h | UTC
Systematic Review: Treatment, Therapy and Management of Metabolic Epilepsy
22 Mar, 2018 | 23:32h | UTC
Review: Prevention of Incisional Hernias after Open Abdomen Treatment
22 Mar, 2018 | 23:33h | UTCPrevention of Incisional Hernias after Open Abdomen Treatment – Frontiers in Surgery (free)
2018 ESC Guidelines for the diagnosis and management of syncope
19 Mar, 2018 | 13:12h | UTC2018 ESC Guidelines for the diagnosis and management of syncope – European Heart Journal (free for a limited period)
Related guideline: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society (free)
Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops
16 Mar, 2018 | 03:37h | UTC#ACC18 – Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops – New England Journal of Medicine (free for a limited period)
Commentaries: Barbershop-Based Intervention Leads to Blood Pressure Reductions in African-American Men – American College of Cardiology (free) AND Mixing Haircuts and Hypertension Rx a ‘Home Run’ for Blood Pressure Control – TCTMD (free)
“Among black male barbershop patrons with uncontrolled hypertension, health promotion by barbers resulted in larger blood-pressure reduction when coupled with medication management in barbershops by specialty-trained pharmacists”.
Research: Carvedilol for Prevention of Chemotherapy Related Cardiotoxicity
16 Mar, 2018 | 03:38h | UTC#ACC18 – Carvedilol for Prevention of Chemotherapy Related Cardiotoxicity – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Beta Blocker Shows Mixed Results in Protecting Against Chemo-Induced Heart Damage – American College of Cardiology (free) AND Carvedilol Effect in Preventing Chemotherapy Induced CardiotoxicitY – CECCY – American College of Cardiology (free)
Related study from #ACC18: Heart Drugs Prevented Cardiotoxicity in Breast Cancer Treated With Anthracycline and Trastuzumab – American College of Cardiology (free)
“According to the CECCY trial, carvedilol had no effect on left ventricular function in breast cancer patients treated w/ doxorubicin, but did result in a reduction in troponin I levels & diastolic dysfunction”. (via @ACCinTouch see Tweet)
Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care
16 Mar, 2018 | 03:36h | UTC#ACC18 – Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care – American College of Cardiology (free) AND Low-Dose, Three-Drug Polypill TRIUMPHs for Blood Pressure – TCTMD (free)
Viewpoint: Big Data and Machine Learning in Health Care
16 Mar, 2018 | 03:35h | UTCBig Data and Machine Learning in Health Care – JAMA (free for a limited period)
Do Antidepressants Work?
16 Mar, 2018 | 03:36h | UTCDo Antidepressants Work? – The New York Times (10 articles per month are free)
“The most comprehensive study on them has recently been published, showing mostly modest effects”.
See related meta-analysis and commentaries in our February 23rd issue (see #3)
Research: Mapping child growth failure in Africa between 2000 and 2015
16 Mar, 2018 | 03:34h | UTCMapping child growth failure in Africa between 2000 and 2015 – Nature (free)
Invited commentary, by Kofi Annan: Data can help to end malnutrition across Africa (free)
Other commentaries: Africa ‘very, very far away’ from meeting global target to end child malnutrition – The Guardian (free) Local Burden of Disease – Child Growth Failure – IHME (free) AND Zooming in on advances and opportunities – IHME (free)
Did a pricey cholesterol-lowering drug really reduce deaths, as headlines claim?
16 Mar, 2018 | 03:33h | UTCSee original article and commentaries in our March 12th issue (see #2)
Editorial: AI diagnostics need attention
16 Mar, 2018 | 03:31h | UTCEditorial: AI diagnostics need attention – Nature (free) (via @RasoiniR see Tweet)
NICE Guideline: Attention deficit hyperactivity disorder
16 Mar, 2018 | 03:34h | UTCGuideline: Attention deficit hyperactivity disorder: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)
The ODYSSEY Trial Ends Well— But Will It Be Enough?
16 Mar, 2018 | 03:32h | UTC#ACC18 – The ODYSSEY Trial Ends Well— But Will It Be Enough? – Cardiobrief (free) AND Ten Quick Thoughts on ODYSSEY – John Mandrola, via Medscape (free registration required)
“An absolute risk reduction of 1.6% in the primary endpoint translates to a number needed to treat of 64. Using the current price of $14,500 per year, Kaul calculated that preventing one event over the trial period of almost 3 years would cost about $2.6 million” (via John Mandrola). This study was presented at #ACC18 and has not been published yet. Among the many commentaries, these two were selected for a balanced point of view.
Grader Variability and the Importance of Reference Standards for Evaluating Machine Learning Models for Diabetic Retinopathy
16 Mar, 2018 | 03:30h | UTCGrader Variability and the Importance of Reference Standards for Evaluating Machine Learning Models for Diabetic Retinopathy – Ophthalmology (link to abstract – $ for full-text)
Commentary: Google’s AI program: Building better algorithms for detecting eye disease – ScienceDaily (free)
Research: Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy
16 Mar, 2018 | 03:29h | UTCAromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentaries: Practice Changing: Inhaled Isopropyl Alcohol Superior to Oral Ondansetron as an Antiemetic – NEJM Journal Watch (free) AND Wake Up And Smell the Isopropyl – Emergency Medicine Literature of Note (free)
Panic, chronic anxiety and burnout: doctors at breaking point
16 Mar, 2018 | 03:30h | UTCPanic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free)
Research: Vitamin D and risk of total and site specific cancers
16 Mar, 2018 | 03:26h | UTC“Wake me up when there is a positive randomized trial of vitamin D pills for anything” (from Richard Lehman’s review).
Richard Lehman’s journal reviews – 12 March 2018
16 Mar, 2018 | 03:28h | UTCRichard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Research: Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention
16 Mar, 2018 | 03:22h | UTC#ACC18 – Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Lipid Lowering in Acute Coronary Syndrome: Is Treatment Early Enough? (free for a limited period)
Commentaries: Statins Evaluation in Coronary Procedures and Revascularization – SECURE-PCI – American College of Cardiology (free) AND No Benefits Likely with Very Early Statins in ACS Patients – MedPage Today (free registration required) AND SECURE-PCI Comes Up Short for Statin Preloading in ACS Patients – TCTMD (free)
Research: Risk of stroke in patients with dengue fever
16 Mar, 2018 | 03:24h | UTCCommentary: Dengue fever linked to increased risk of stroke – CMAJ, via ScienceDaily (free)
Acute Myocardial Infarction Mortality During Dates of National Interventional Cardiology Meetings
16 Mar, 2018 | 03:23h | UTCCommentaries: Survival benefit seen for some patients when cardiologists are away at academic conferences – Harvard Medical School, via ScienceDaily (free) AND TCT paradox: Patients more likely to survive MI during interventional cardiology conference – Cardiovascular Business (free)
Related study: Mortality and Treatment Patterns Among Patients Hospitalized With Acute Cardiovascular Conditions During Dates of National Cardiology Meetings – JAMA Internal Medicine (free)
“The study’s release date is particularly timely considering another major conference—the American College of Cardiology’s Scientific Session—kicks off this weekend”. (from Cardiovascular Business)
Research: Inflammatory Bowel Disease Linked to Increased Risk in Heart Attack
16 Mar, 2018 | 03:18h | UTC#ACC18 – Inflammatory Bowel Disease Increases Likelihood of a Heart Attack – American College of Cardiology (free) AND Inflammatory bowel disease may raise heart attack risk – Medical News Today (free) AND Those with IBD twice as likely to have heart attack – Cardiovascular Business (free) AND Inflammatory Bowel Disease Makes Heart Attack Twice as Likely – Cardiosmart (free)
Meta-analysis: Getting flu shot may reduce deaths in heart failure
16 Mar, 2018 | 03:16h | UTC#ACC18 – Getting flu shot halves death risk for heart failure patients – Cardiovascular Business (free) AND Flu Vaccine Reduces Mortality, Hospitalization in HF Patients: Meta-analysis – TCTMD (free) AND Flu Shot Cuts Risk for Death by Half in Heart Failure – Medscape (free registration required) AND Getting Flu Vaccine Cuts Risk of Death by Half in People with Heart Failure – American College of Cardiology (free)
This meta-analysis of observational studies suggests a possible benefit.
Research: Hospital Readmission After Perioperative Acute Myocardial Infarction Associated With Noncardiac Surgery
16 Mar, 2018 | 03:20h | UTC#ACC18 – Hospital Readmission After Perioperative Acute Myocardial Infarction Associated With Noncardiac Surgery – Circulation (free PDF for a limited period)
Commentaries: Hospital Readmissions After Perioperative AMI – American College of Cardiology, Latest in Cardiology (free) AND Perioperative MIs Bring Too Many Patients Back to the Hospital After Noncardiac Surgery – TCTMD (free)