Tue October 15 – 10 Stories of The Day!

1 – Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial – The Lancet (free)

Commentaries: CRASH-3: a win for patients with traumatic brain injury – The Lancet (free) AND Global trial is first clear evidence that a widely available drug reduces head injury deaths – London School of Hygiene & Tropical Medicine (free) AND PulmCrit- Tranexamic acid for traumatic brain injury (CRASH3) (free) AND CRASH-3! – Emergency Medicine Literature of Note (free) AND Head injuries: Cheap drug ‘could save thousands of lives a year’ – BBC (free) AND Common drug could prevent thousands of head injury deaths – The Guardian (free)

Related: Evidence Review: Tranexamic Acid (TXA) for Everything that Bleeds? (free resources on the subject)

2 – Conservative Oxygen Therapy during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: No clear benefit from conservative oxygen in mechanical ventilation – CHEST Physician (free) AND Trial: No Need for Intensive Oxygen in the ICU – MedPage Today (free registration required)

3 – Diabetic foot problems: prevention and management – National Institute for Health and Care Excellence (free)

Related: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free) AND Diabetic foot – The BMJ (free) AND Diagnosis and Management of Diabetic Foot Complications – American Diabetes Association (free) AND Prevention, assessment, diagnosis and management of diabetic foot based on clinical practice guidelines: A systematic review – Medicine (free)

4 – Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Non-pharmacologic treatments may be more effective for psychiatric symptoms of dementia – St. Michael’s Hospital (free) AND To ease dementia agitation, drugs may not be best option – Reuters (free)

5 – Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Rivaroxaban Not Noninferior to VKAs for Antiphospholipid Antibody Syndrome – NEJM Journal Watch (free) AND DOAC Disappoints in Thrombotic Autoimmune Disorder – MedPage Today (free registration required)

6 – Wirelessly observed therapy compared to directly observed therapy to confirm and support tuberculosis treatment adherence: A randomized controlled trial – PLOS Medicine (free)

Commentary: Ingestible sensor allows patients to be independent but still supported during TB treatment – Specialists in Global Health (free)

7 – #177 Osteoarthritis Master Class with Tuhina Neogi MD, PhD – The Curbsiders Internal Medicine Podcast (free)

See also: Episodes List

8 – Management of Itch in the Elderly: A Review – Dermatology and Therapy (free)

9 – Youth suicide attempts often involve over-the-counter painkillers – Reuters (free)

Original Study: Suicide attempts by self-poisoning in the United States among 10–25 year olds from 2000 to 2018: substances used, temporal changes and demographics – Journal of Clinical Toxicology (free)

10 – Oral Paracetamol Versus Combination Oral Analgesics for Acute Musculoskeletal Injuries – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: RCT – APAP Only vs APAP-Ibuprofen-Codeine Combo – Journal Feed (free)