Systematic review: Safety and effectiveness of metformin in patients with reduced renal function – safe and beneficial at a eGFR of 45 mL/min/1.73m2 or higher; possibly harmful at an eGFR of less than 30 mL/min/1.73m2.

Safety and effectiveness of metformin in patients with reduced renal function: A systematic review – Diabetes, Obesity and Metabolism

Commentary on Twitter

Safety of metformin for T2 diabetes in people with reduced kidney function

Associated with ⬇️ mortality and no ⬆️ risk of acidosis at an eGFR of > 45 

Associated with fewer benefits & possible ⬆️ in the risk of acidosis at an eGFR <30 https://t.co/uOyarn11hM@goKDIGO pic.twitter.com/Ca05gc7FHi

— Kamlesh Khunti (@kamleshkhunti) June 16, 2021