Systematic Review: Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. 6 Mar, 2022 | 23:41h | UTC Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding – Cochrane Library Commentary: Pre-Endoscopic Proton Pump Inhibitor Use May Decrease Risk for Endoscopic Hemostatic Treatment – Gastroenterology Advisor