Study suggests long-term caloric restriction could slow biological aging in healthy adults

Summary: The article reports the results of a study that analyzed the impact of caloric restriction (CR), defined as reducing caloric intake without depriving essential nutrients, on DNA methylation, a measure of aging, in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial. The results showed that the CALERIE intervention slowed the pace of aging, as measured by the DunedinPACE DNAm algorithm, but did not lead to significant changes in biological age estimates measured by various DNAm clocks. The authors note that while treatment effect sizes were small, a modest slowing of the pace of aging can have a significant impact on population health. They also highlight the need for further trials with long-term follow-up to establish the effects of interventions on primary healthy-aging endpoints, including the incidence of chronic disease and mortality.

(By ChatGPT, reviewed and edited)

Article: Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial – Nature Aging

Commentaries:

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging – News Medical

Expert reaction to study looking at long-term caloric restriction on DNA methylation measures of biological aging in healthy adults – Science Media Centre

Restrict calories to live longer, study says, but critics say more proof is needed – CNN