Single-arm phase 2 study | A less intensive treatment strategy may be effective for patients with stage IIA and stage IIB seminoma.

Single-dose carboplatin followed by involved-node radiotherapy for stage IIA and stage IIB seminoma (SAKK 01/10): a single-arm, multicentre, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: De-escalation Strategy in Seminoma: An Alternative Option? – Medscape (free registration required)

Commentary on Twitter

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SAKK 01/10 results are out!! 👇🏽

Stage IIA/B testicular seminoma➡️
1️⃣cycle of carboplatin+involved node RT
116 pts, median FU 4.5yrs
3yr PFS 93.7%, 7 relapses, all successfully salvaged. Seminoma-specific surv 💯%
Generally well tolerated, gr3+tox chemo-related https://t.co/vI6ipafhZ8

— Sophia Kamran, MD (@sophia_kamran) October 11, 2022