Seroconversion and fever are dose-dependent in a nonhuman primate model of inhalational COVID-19.
13 Oct, 2021 | 01:41h | UTCCommentary: Dose-dependent COVID-19 symptoms – Nature Reviews Microbiology
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When exposed to #SARSCoV2 why does one person have no illness, while another is soon in ICU?
Dose.
Controlled study in monkeys shows the dose of viruses inhaled is a key factor determining the severity of the disease.
Seems obvious, yet this is new.https://t.co/zdfCnR40bR pic.twitter.com/HH8kxMM2xm— Laurie Garrett (@Laurie_Garrett) October 11, 2021
In summer of 2020, our group had proposed a hypothesis that SARS-CoV-2 viral dose or "inoculum" was associated with severity of symptoms in COVID (and proposed NPIs reduced the dose). There is now an experimental model showing this in cynomolgus monkeys:https://t.co/dXGDPyPBFZ
— Monica Gandhi MD, MPH (@MonicaGandhi9) October 12, 2021