RCT: In children with relapsing steroid-sensitive nephrotic syndrome with acute respiratory tract infection, a daily low dose of prednisolone did not reduce the risk of relapse.

Evaluation of Daily Low-Dose Prednisolone During Upper Respiratory Tract Infection to Prevent Relapse in Children With Relapsing Steroid-Sensitive Nephrotic Syndrome: The PREDNOS 2 Randomized Clinical Trial – JAMA Pediatrics

Commentary: PREDNOS 2: Prednisolone Doesn’t Lower Relapse Risks in Kids with Nephrotic Syndrome – Physician’s Weekly

Commentary on Twitter

In a large non-selected sample of children (365) with relapsing steroid sensitive nephrotic syndrome, the PREDNOS 2 RCT has shown that low dose prednisolone given for 6 days at the start of an URTI does not reduce the risk of relapse https://t.co/9271PHQh0r

— JAMA Pediatrics (@JAMAPediatrics) December 20, 2021