RCT: Among patients with bipolar disorder or depression who had survived a recent suicide-related event, Lithium as an add on therapy was not effective for the prevention of repeat suicide-related outcomes.

Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder – JAMA Psychiatry (free for a limited period)

Author Interview: Lithium for Suicide-Related Outcome Prevention in Veterans With Major Depression or Bipolar Disorder

Commentary: Lithium Added To Current Tx Fails to Reduce Suicide-Related Events in Veterans – Physician’s Weekly

Commentary on Twitter

VA Trial findings suggest simply adding lithium to existing medication in patients with #bipolar disorder or major depressive disorder is unlikely to be effective for preventing a broad range of repeat suicide-related events. https://t.co/QOj5UhEFKh

— JAMA Psychiatry (@JAMAPsych) November 17, 2021