Mon, September 25 – 10 Stories of The Day!

1 – The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study – The Lancet (link to abstract – $ for full-text)

Commentaries: Any type of physical exercise is good for the heart – NHS Choices (free) AND Physical Activity of Any Ilk Cuts CVD, Deaths in Global Study: PURE – TCTMD (free) AND Being active saves lives whether a gym workout, walking to work or washing the floor – McMaster University, via ScienceDaily (free) AND Don’t overthink your exercise: just 2.5 hours per week of any kind could help you live longer – VOX (free) AND A daily half hour’s exercise could prevent 1 in 12 early deaths, study shows – Reuters (free)

2 – The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis – Psychotherapy and Psychosomatics (link to abstract – $ for full-text)

Commentaries: Antidepressant use associated with higher risk of death – OnMedica (free) AND Antidepressants may raise death risk by a third – Medical News Today (free) AND Antidepressants Tied to a Significantly Increased Risk for Death – Medscape (free registration required) AND Antidepressants Associated with Significantly Elevated Risk of Death, Researchers Find – McMaster University, via NewsWise (free)

3 – Adherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Study Questions Incremental Benefit of Beta-Blockers After Acute MI – TCTMD (free) AND Beta blockers not needed after heart attack if other medications taken – University of North Carolina at Chapel Hill, via Eurekalert (free) AND Adherence to medications post-MI is below 50%; beta-blockers offer little incremental benefit – Cardiovascular Business (free)

Related study published recently: β-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

4 – 2017 AHA/ACC Clinical Performance and Quality Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (free)

5 – Homepage: Cardiomyopathy Compendium – Circulation Research

– Cardiomyopathies: An Overview, by Eugene Brawnwald (free)

– Classification, Epidemiology, and Global Burden of Cardiomyopathies (free)

– Dilated Cardiomyopathy: Genetic Determinants and Mechanisms (free)

– Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation (free)

– Arrhythmogenic Cardiomyopathy (free)

– Inflammatory Cardiomyopathic Syndromes (free)

– Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism (free)

– Pediatric Cardiomyopathies (free)

– Modern Imaging Techniques in Cardiomyopathies (free)

Source: Critical Care Reviews Newsletter

6 – Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives (free)

Commentaries: Montelukast Tied to Psychiatric Adverse Events in Kids, Adults – Medscape (free registration required) AND Asthma Drug, Montelukast, Tied to Nightmares, Depression – Drugs.com (free)

7 – Effect of Post–Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Post-Cesarean Antibiotics Reduce Risk for Surgical Site Infections in Obese Women – Physician’s First Watch (free) AND Antibiotics After C-Section Cut Infections in Obese Women – MedPage Today (free registration required) AND Antibiotics cut infection risk in obese women after caesarean – OnMedica (free)

8 – Interventions for treating tuberculous pericarditis – Cochrane Library (free)

News release: Treatment for tuberculosis infection of the membrane around the heart (free)

“For HIV-negative patients, corticosteroids may reduce death. For HIV-positive patients not on antiretroviral drugs, corticosteroids may reduce constriction. For HIV-positive patients with good antiretroviral drug viral suppression, clinicians may consider the results from HIV-negative patients more relevant”.

9 – Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

“The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

10 – Blood test and ECG may safely rule out heart attack – NIHR Signal (free)

Original article: Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) and Commentary: High-sensitivity troponin T result may help rule out of myocardial infarction – 2 Minute Medicine (free)