Fri July 26 – 10 Stories of The Day!

1 – ACG Clinical Guideline: Hereditary Hemochromatosis – The American Journal of Gastroenterology (free PDF)

Related Guidelines: Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (free) AND Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype – Hepatology International (free)

2 – Clinical Guide and Update on Porphyrias – Gastroenterology (free)

Related Reviews: Update review of the acute porphyrias – British Journal of Haematology (free) AND Acute Hepatic Porphyrias: Review and Recent Progress – Hepatology Communications (free) AND Acute hepatic porphyrias: Recommendations for evaluation and long‐term management – Hepatology (free) AND An overview of the cutaneous porphyrias – F1000 Research (free)

3 – Diagnosis of elevated intracranial pressure in critically ill adults: systematic review and meta-analysis – The BMJ (free)

Commentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)

Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)

Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)

4 – Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis – The BMJ (free)

Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)

“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”

5 – Harms from Uninformative Clinical Trials – JAMA (free for a limited period)

“An uninformative trial is one that provides results that are not of meaningful use for a patient, clinician, researcher, or policy maker.”

6 – Realizing Shared Decision-making in Practice – JAMA (free for a limited period)

Related Viewpoint: Shared Decision Making and the Importance of Time – JAMA (free)

7 – Impact of furosemide on mortality and the requirement for renal replacement therapy in acute kidney injury: a systematic review and meta-analysis of randomised trials – Annals of Intensive Care (free)

8 – Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial – Gastroenterology (free)

9 – Interventions for preventing obesity in children – Cochrane Library (free)

Summary: Do diet and physical activity strategies help prevent obesity in children (aged 0 to 18 years)? – Cochrane Library (free)

10 – Rhythm control for patients with atrial fibrillation complicated with heart failure in the contemporary era of catheter ablation: a stratified pooled analysis of randomized data – European Heart Journal (link to abstract – $ for full-text)

Commentary: Rhythm Control for Atrial Fibrillation With Heart Failure – American College of Cardiology (free)

Related Meta-Analysis: Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction (free)