Cohort Study | The risk of opioid overdose is increased with concomitant use of oxycodone and selective serotonin reuptake inhibitors that are inhibitors of oxycodone metabolism.

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors – JAMA Network Open

Commentary from the author: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation

Commentary on Twitter

This cohort study found that concomitant use of oxycodone with potent CYP2D6-inhibiting serotonin reuptake inhibitors (SSRIs, eg. fluoxetine or paroxetine) is associated with an increased risk of overdose. https://t.co/Eol89RHWAu

— JAMA Network Open (@JAMANetworkOpen) February 24, 2022