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Cohort Study | COVID-19 outpatients mostly at low risk for VTE, but age, being male, and obesity are risk factors

17 Mar, 2023 | 13:11h | UTC

Summary: The article discusses a cohort study that aimed to assess the risk of venous thromboembolism (VTE) among outpatients with COVID-19 and identify independent predictors of VTE.

The study used data from two integrated healthcare delivery systems in California and included 398.530 nonhospitalized adults aged 18 years or older with COVID-19 diagnosed between January 1, 2020, and January 31, 2021, with follow-up through February 28, 2021.

The results showed that the overall risk of VTE among outpatients with COVID-19 is low, but higher in the first 30 days after diagnosis. Factors associated with a higher risk of VTE in COVID-19 outpatients included:


  • Age 55 years or older.
  • Being male.
  • history of VTE or thrombophilia.
  • Body mass index greater than or equal to 30.0.


The study’s results could inform future randomized trials to explore targeted VTE preventive strategies and more intensive short-term surveillance for patients with COVID-19 who are at a higher risk of developing VTE.

Article: Assessment of the Risk of Venous Thromboembolism in Nonhospitalized Patients With COVID-19 – JAMA Network Open

Commentary: Venous blood clots rare among COVID-19 outpatients, study finds – CIDRAP


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