Another study suggests that PPIs may increase the risk of chronic kidney disease, especially with prolonged use 16 Apr, 2016 | 13:58h | UTC Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) Proton Pump Inhibitors May Increase Risk for Kidney Disease – Medscape commentary (free registration required) Related Article Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease – JAMA (link to abstract – subscription required for full text) PPIs Associated with Increased Risk for Chronic Kidney Disease – NEJM Physician’s First Watch Commentary (Free) Proton Pump Inhibitors May Increase Risk for Kidney Disease – Medscape commentary (Free registration required)