Another randomized trial shows no benefit from ascorbic acid, corticosteroids, and thiamine in septic shock

Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial – JAMA (free for a limited period)

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In this RCT, a combination of hydrocortisone, ascorbic acid, and thiamine (the HAT or Marik protocol) did not statistically significantly reduce SOFA score or mortality within 72 hours of enrollment among patients with septic shock https://t.co/cuB6X4fJhi

— JAMA (@JAMA_current) August 18, 2020