Daily Archives: June 7, 2023
RCT | Multivitamin supplementation may improve memory in aged adults
7 Jun, 2023 | 14:12h | UTCMultivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)
News Releases:
Multivitamin Improves Memory in Older Adults, Study Finds – Columbia University
Related Research: Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial – Alzheimer’s & Dementia
SR | Limited evidence for vitamin and mineral supplements in delaying dementia in people with mild cognitive impairment
7 Jun, 2023 | 14:09h | UTC
Commentary on Twitter
? How does vitamin and mineral supplementation affect #cognitivefunction and progression to #dementia in people with mild cognitive impairment (MCI)?
Get the current evidence picture in this #systematicreview on @CochraneLibrary: https://t.co/YUsbjELIZq@NIH_ODS #NSHFD pic.twitter.com/hRl27Tm7op— Cochrane CAM (@CochraneCAM) May 31, 2023
Review | Reducing the carbon footprint and resource use of critical care
7 Jun, 2023 | 14:07h | UTCTowards net zero: critical care – The BMJ (free for a limited period)
Commentary on Twitter
ICUs are a considerable contributor to the carbon footprint of hospitals.
This article and #BMJInfographic present ways to reduce wastehttps://t.co/F2DPQcFnCy pic.twitter.com/bHwu9YZEgo
— The BMJ (@bmj_latest) June 3, 2023
RCT | Preoperative FOLFOX noninferior to chemoradiotherapy in locally advanced rectal cancer
7 Jun, 2023 | 14:06h | UTCPreoperative Treatment of Locally Advanced Rectal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Related Publication: Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048) – Journal of Clinical Oncology
Commentary: Radiation May Be Safely Omitted in Select Patients With Locally Advanced Rectal Cancer – The ASCO Post
Commentary on Twitter
Original Article: Preoperative Treatment of Locally Advanced Rectal Cancer (PROSPECT) https://t.co/6ubagrEzyw#ASCO23 pic.twitter.com/g2XFBkEk4T
— NEJM (@NEJM) June 5, 2023
RCT | Vorasidenib enhances PFS in IDH1/2-mutant low-grade glioma, trial methods debated online
7 Jun, 2023 | 14:04h | UTCVorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Vorasidenib Delays Disease Progression or Death in Patients With Grade 2 IDH-Mutated Glioma – The ASCO Post
Commentary on Twitter questioning study methodology (thread – click for more)
This is a rather troubling study. The fact that it got published in @NEJM is concerning, to say the least
Astonishing cost of $16 000/month for a drug administered continuously until disease progression in a trial with a dubious endpoint and flawed design
Here are my thoughts: https://t.co/E3QtZfEyQw
— Stanislav (Stas) Lazarev, MD (@StasLazarev) June 5, 2023
AHA Scientific Advisory | Digital technologies in cardiac rehabilitation
7 Jun, 2023 | 14:23h | UTCTop Things to Know: Digital Technologies in CR – American Heart Association
JACC Scientific Statement | Remote monitoring for heart failure management at home
7 Jun, 2023 | 14:00h | UTC
Commentary on Twitter
New #JACC Scientific Statement spanning remote monitoring to integrated mgmt of #HeartFailure.
Updates in physiology of congestion, monitoring signals, & #DigitalHealth tech will support clinical teams to connect circles of care/self-care of #HF at home! https://t.co/TyaXT1P1hg pic.twitter.com/0u5STreIDQ
— JACC Journals (@JACCJournals) June 6, 2023
AAOS Appropriate Use Criteria | Prevention of surgical site infections after major extremity trauma
7 Jun, 2023 | 13:58h | UTCRelated:
Global guidelines on the prevention of surgical site infection – World Health Organization
AAOS Guideline: Prevention of surgical site infections after major extremity trauma.
Magnetic resonance imaging to evaluate kidney structure, function, and pathology: moving towards clinical application
7 Jun, 2023 | 13:57h | UTC
RCT | Atezolizumab and cabozantinib combo fails to outperform cabozantinib alone in renal cell carcinoma
7 Jun, 2023 | 13:54h | UTCAtezolizumab plus cabozantinib versus cabozantinib monotherapy for patients with renal cell carcinoma after progression with previous immune checkpoint inhibitor treatment (CONTACT-03): a multicentre, randomised, open-label, phase 3 trial – The Lancet (free registration required)
Commentary from the author on Twitter (thread – click for more)
1/ Results from #CONTACT03 are out both @ASCO #ASCO23 and @TheLancet . The 1⃣st phase 3 trial to assess the efficacy of rechallenge with anti-PDL1 in ANY cancer type.
Kudos to @montypal, SC members, @roche, our patients, = for this phenomenal job. https://t.co/p7hYD4snXA pic.twitter.com/CXk1vqfB26— Toni Choueiri, MD (@DrChoueiri) June 5, 2023
M-A | Advance care planning for frail elderly: are we missing a golden opportunity?
7 Jun, 2023 | 13:53h | UTC
Exploratory Analysis of a RCT | Low-dose colchicine linked to reduced incidence of knee and hip replacements
7 Jun, 2023 | 13:50h | UTCAssociation of Low-Dose Colchicine With Incidence of Knee and Hip Replacements: Exploratory Analyses From a Randomized, Controlled, Double-Blind Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Low dose colchicine associated with lower incidence of total knee and hip replacements – American College of Physicians
Cohort Study | Coronary artery calcium score superior to polygenic score for CHD risk prediction
7 Jun, 2023 | 13:51h | UTCCoronary Artery Calcium Score and Polygenic Risk Score for the Prediction of Coronary Heart Disease Events – JAMA (link to abstract – $ for full-text)
News Release: CT scan best at predicting heart disease risk in middle age: Scan beats genetics to gauge risk – Northwestern University
Practice Guidance | Management of patients with differing heart failure phenotypes
7 Jun, 2023 | 13:45h | UTC
Review | Erythrocyte sedimentation rate and C-reactive protein in the ED
7 Jun, 2023 | 13:47h | UTCErythrocyte Sedimentation Rate and C-Reactive Protein in the ED – emDocs
Guideline | Managing chemotherapy-induced nausea and vomiting in pediatric cancer
7 Jun, 2023 | 13:43h | UTC
RCT | Adding dalpiciclib to standard letrozole or anastrozole treatment outperforms placebo in HR+, HER2- advanced breast cancer
7 Jun, 2023 | 13:44h | UTCDalpiciclib plus letrozole or anastrozole versus placebo plus letrozole or anastrozole as first-line treatment in patients with hormone receptor-positive, HER2-negative advanced breast cancer (DAWNA-2): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: Dalpiciclib Combo Improves PFS Vs Placebo in HER2– Advanced Breast Cancer – Cancer Network
Guideline Series | Prevention and management of diabetes-related foot disease
7 Jun, 2023 | 13:41h | UTCDefinitions and criteria for diabetes-related foot disease (IWGDF 2023 update)
Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update)
Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update)
M-A | Effects of physical exercise on physical function in older adults in residential care
7 Jun, 2023 | 13:39h | UTCInvited commentary: Is there enough evidence to prescribe exercise to older adults living in residential care? – The Lancet Health Longevity