Daily Archives: May 31, 2023 | LinksMedicus Free Medical News & Perspectives

RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³

31 May, 2023 | 14:20h | UTC

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Research from Amsterdam UMC shows that the bottom has been reached in restrictive blood transfusion policy – Amsterdam University Medical Centers

Commentary on Twitter

Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.

— NEJM (@NEJM) May 27, 2023

RCT | Early initiation of DOACs not statistically superior to later use in atrial fibrillation-related stroke

31 May, 2023 | 14:17h | UTC

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

ELAN: Early DOACs Safe, May Help After Ischemic Stroke in AF Patients – TCTMD

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischemic Stroke Patients With Atrial Fibrillation – ELAN – American College of Cardiology

Commentary on Twitter

Late breaking at #ESOC2023: In the ELAN trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants. Full results:

— NEJM (@NEJM) May 24, 2023

RCT | Ketamine non-Inferiority to ECT for nonpsychotic resistant depression

31 May, 2023 | 14:15h | UTC

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study Finds Ketamine is at Least as Effective as ECT for Treating Major Depression – Mass General Brigham

Commentary: Expert reaction to trial looking at ketamine versus ECT for nonpsychotic treatment-resistant major depression – Science Media Centre

RCT | P2Y12 inhibitors don’t improve outcomes in critically ill COVID-19 patients

31 May, 2023 | 14:13h | UTC

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

Proposing a new five-type classification for glomerulonephritis based on pathogenesis, activity, and chronicity

31 May, 2023 | 14:11h | UTC

The five types of glomerulonephritis classified by pathogenesis, activity, and chronicity (GN-AC) – Nephrology Dialysis Transplantation

Commentary on Twitter

The five types of glomerulonephritis classified by pathogenesis, activity & chronicity (GN-AC)
?https://t.co/NYKBde4L1I
?The major entities of GN
?Autoantigens in autoimmune GN
?Multilevel diagnostic algorithm of GN
?Proposed GN-AC classification & reporting system for GN pic.twitter.com/shmLLhCfJk

— NDT (@NDTsocial) May 24, 2023