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Daily Archives: April 28, 2023

M-A | Low-dose triple and quadruple antihypertensives outperform monotherapy in blood pressure reduction

28 Apr, 2023 | 13:23h | UTC

Efficacy and Safety of Low-Dose Triple and Quadruple Combination Pills vs Monotherapy, Usual Care, or Placebo for the Initial Management of Hypertension: A Systematic Review and Meta-analysis – JAMA Cardiology (free for a limited period)

Commentary: Low-Dose Polypills Top Other Approaches for Initial BP Control: Meta-analysis – TCTMD

Related: #ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).

 


AHA Scientific Statement | Assessing popular diets in relation to 2021 American Heart Association dietary recommendations

28 Apr, 2023 | 13:21h | UTC

Popular Dietary Patterns: Alignment With American Heart Association 2021 Dietary Guidance: A Scientific Statement From the American Heart Association – Circulation

Top Things to Know: Popular Dietary Patterns: Alignment with AHA 2021 Dietary Guidance – American Heart Association

 

Commentary on Twitter

 


Cohort Study | Risk of multiple morbidities across the lifespan in people with Down syndrome or intellectual disabilities

28 Apr, 2023 | 13:19h | UTC

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records – The Lancet Public Health

 

Commentary from the author on Twitter (thread – click for more)

 


Global burden of chronic respiratory diseases and risk factors, 1990–2019

28 Apr, 2023 | 13:17h | UTC

Global burden of chronic respiratory diseases and risk factors, 1990–2019: an update from the Global Burden of Disease Study 2019 – eClinicalMedicine

News Release: Chronic respiratory disease is third leading cause of death globally with air pollution killing 1.3 million people – IHME

 

Commentary on Twitter (thread – click for more)

 


RCT | Molecular point-of-care testing for gastroenteritis reduced isolation time but increased antibiotic use

28 Apr, 2023 | 13:15h | UTC

Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial – The Lancet Infectious Diseases

Commentary: Molecular testing in suspected infectious diarrhoea—the value of negative results – The Lancet Infectious Diseases

 


CHEST/AARC/ATS/CTS Research Statement | Effect of race and ethnicity on pulmonary function testing interpretation

28 Apr, 2023 | 13:10h | UTC

Effect of Race and Ethnicity on Pulmonary Function Testing Interpretation: A CHEST/AARC/ATS/CTS Evidence Review and Research Statement – Chest

Commentary: Pulmonary Testing Based on Race, Ethnicity Found Flawed – Medscape (free registration required)

 


RCT | Albuterol–budesonide pressurized metered dose inhaler in patients with mild-to-moderate asthma

28 Apr, 2023 | 13:13h | UTC

Albuterol–budesonide pressurized metered dose inhaler in patients with mild-to-moderate asthma: results of the DENALI double-blind randomized controlled trial – Chest

Related study: Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma – New England Journal of Medicine

 


Single-arm study | Blinatumomab added to chemotherapy in infant lymphoblastic leukemia

28 Apr, 2023 | 13:08h | UTC

Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia – New England Journal of Medicinev (link to abstract – $ for full-text)

News Release: Immunotherapy strongly improves prognosis of babies with leukemia – Princess Máxima Center

 

Commentary on Twitter

https://twitter.com/NEJM/status/1651335340916109313

 


Survey | What symptoms come first in degenerative cervical myelopathy?

28 Apr, 2023 | 13:05h | UTC

Targeting earlier diagnosis: What symptoms come first in Degenerative Cervical Myelopathy? – PLOS One

Commentary: Identifying the initial symptoms to degenerative cervical myelopathy – 2 minute medicine

 


Review | Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma

28 Apr, 2023 | 13:03h | UTC

Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma – CA: A Cancer Journal for Clinicians

 


Criteria for placental examination for obstetrical and neonatal providers

28 Apr, 2023 | 13:06h | UTC

Criteria for placental examination for obstetrical and neonatal providers – American Journal of Obstetrics & Gynecology

 


Single-arm trial | Retroperitoneal lymph node dissection as first-line treatment for early metastatic seminoma shows 81% 2-Year RFS

28 Apr, 2023 | 13:02h | UTC

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy – Journal of Clinical Oncology

News Release: Surgery proves effective alternative to chemotherapy and radiation for early metastatic testicular cancer – Keck Medicine of USC

Commentary: Retroperitoneal Lymph Node Dissection for Early Metastatic Testicular Seminoma – The ASCO Post

 


Guideline | Transient global amnesia

28 Apr, 2023 | 12:59h | UTC

Guideline “Transient Global Amnesia (TGA)” of the German Society of Neurology (Deutsche Gesellschaft für Neurologie): S1-guideline – Neurological Research and Practice

 


Review | Should RAAS blockade therapy be continued in patients with advanced renal disease?

28 Apr, 2023 | 13:00h | UTC

Should RAAS blockade therapy be continued in patients with advanced renal disease? – MDedge

 


Position Statement | Transthoracic echocardiographic assessment of the heart in pregnancy

28 Apr, 2023 | 12:57h | UTC

Transthoracic Echocardiographic Assessment of the Heart in Pregnancy—a position statement on behalf of the British Society of Echocardiography and the United Kingdom Maternal Cardiology Society – Echo Research & Practice

 


M-A | Immune checkpoint inhibitors vs. chemotherapy in the 2nd-line treatment of advanced esophageal squamous cell carcinoma

28 Apr, 2023 | 12:56h | UTC

Efficacy and safety of immune checkpoint inhibitors versus chemotherapy in the second-line treatment of advanced esophageal squamous cell carcinoma: a meta-analysis and systematic review – Journal of Thoracic Disease

 


Pre-Post Study | Machine learning informs mortality risk, increases advanced care planning rates in hospitalized patients

28 Apr, 2023 | 12:54h | UTC

Advanced Care Planning for Hospitalized Patients Following Clinician Notification of Patient Mortality by a Machine Learning Algorithm – JAMA Network Open

 

Commentary on Twitter

 


Rapid reviews methods series | Involving patient and public partners, healthcare providers and policymakers as knowledge users

28 Apr, 2023 | 12:52h | UTC

Rapid Reviews Methods Series: Involving patient and public partners, healthcare providers and policymakers as knowledge users – BMJ Evidence-Based Medicine

 


Rapid reviews methods series | Guidance on assessing the certainty of evidence

28 Apr, 2023 | 12:51h | UTC

Rapid reviews methods series: Guidance on assessing the certainty of evidence – BMJ Evidence-Based Medicine

 


Rapid reviews methods series | Guidance on literature search

28 Apr, 2023 | 12:49h | UTC

Rapid reviews methods series: Guidance on literature search – BMJ Evidence-Based Medicine

 


Rapid reviews methods series | Guidance on team considerations, study selection, data extraction and risk of bias assessment

28 Apr, 2023 | 12:48h | UTC

Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment – BMJ Evidence-Based Medicine

 


Extracorporeal CPR dissemination and integration with organ preservation in the USA: ethical and logistical considerations

28 Apr, 2023 | 12:47h | UTC

Extracorporeal cardiopulmonary resuscitation dissemination and integration with organ preservation in the USA: ethical and logistical considerations – Critical Care

 


Cohort Study | The association between antihypertensive treatment and serious adverse events by age and frailty

28 Apr, 2023 | 12:45h | UTC

The association between antihypertensive treatment and serious adverse events by age and frailty: A cohort study – PLOS Medicine

 


Guideline | Significance of the comprehensive geriatric assessment in the administration of chemotherapy to older adults with cancer

28 Apr, 2023 | 12:43h | UTC

Significance of the comprehensive geriatric assessment in the administration of chemotherapy to older adults with cancer: Recommendations by the Japanese Geriatric Oncology Guideline Committee – Journal of Geriatric Oncology

 


A systematic review on clinical guidelines of home health care in heart failure patients

28 Apr, 2023 | 12:41h | UTC

A systematic review on clinical guidelines of home health care in heart failure patients – BMC Nursing

 


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