Daily Archives: April 17, 2023
Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU
17 Apr, 2023 | 13:19h | UTCGuidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)
Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals
17 Apr, 2023 | 13:17h | UTCCommentary: New guidance deems antibiotic stewardship essential for preventing C diff infections – CIDRAP
National clinical guideline for stroke for the UK and Ireland
17 Apr, 2023 | 13:15h | UTCNational clinical guideline for stroke for the UK and Ireland – Stroke Working Party (Full PDF here)
RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs
17 Apr, 2023 | 13:14h | UTCHeterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Personalized blood pressure treatment more effective – Uppsala University
Phase 2 RCT | High-dose VE303 reduces recurrent Clostridioides difficile infection rates
17 Apr, 2023 | 13:12h | UTCVE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Identifying perioperative anaphylaxis in Japan: epidemiology, allergens, and diagnostic tools
17 Apr, 2023 | 13:10h | UTC
Propofol and survival: an updated meta-analysis of randomized clinical trials
17 Apr, 2023 | 13:09h | UTCPropofol and survival: an updated meta-analysis of randomized clinical trials – Critical Care
Commentary on Twitter (thread – click for more)
Big headline: 252 RCTs looking at more than 30,000 patients show propofol increases mortality compared to ‘other’ (RR 1.10, 95% CI 1.01-1.20, p = 0.03). This translates to an NNH of 235.
Interesting one. Where does the effect stem from? 1/8https://t.co/8z8Z1OE0I3
— Jan Hansel (@VirtueOfNothing) April 14, 2023
Cohort Study | Association between hearing aid use and all-cause and cause-specific dementia
17 Apr, 2023 | 13:07h | UTCCommentaries: Preventing dementia through correcting hearing: huge progress but more to do – The Lancet Public Health
News Release: Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests – Lancet
Related:
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
Dementia and hearing-aid use: a two-way street – Age and Ageing
Association of Hearing Loss With Dementia – JAMA Network Open
Commentary on Twitter
NEW—Hearing aids may protect against a higher risk of #dementia associated with hearing loss, a @TheLancetPH study suggests.https://t.co/Yliq2wT7SR pic.twitter.com/v3iuTuHYVI
— The Lancet (@TheLancet) April 13, 2023
RCT | Exercise and protein intervention may improve resilience and reduce frailty in seniors
17 Apr, 2023 | 13:04h | UTC
Phase 2 RCT | Dersimelagon in erythropoietic protoporphyrias
17 Apr, 2023 | 13:05h | UTCDersimelagon in Erythropoietic Protoporphyrias – News England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In a phase 2 trial, once-daily oral treatment with dersimelagon safely improved tolerance to sun exposure in patients with erythropoietic protoporphyria and X-linked protoporphyria. https://t.co/peZye8R5T7 pic.twitter.com/DO2HmKkM1f
— NEJM (@NEJM) April 12, 2023
SR | Oral direct thrombin inhibitors vs. conventional anticoagulants for the treatment of pulmonary embolism
17 Apr, 2023 | 13:02h | UTC
M-A | Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer
17 Apr, 2023 | 12:59h | UTC
RCT | Methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis
17 Apr, 2023 | 12:58h | UTCEfficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial – Nephrology Dialysis Transplantation (free for a limited period)
RCT | Zolbetuximab plus mFOLFOX6 in CLDN18.2+ HER2- advanced gastric or gastro-oesophageal junction adenocarcinoma
17 Apr, 2023 | 13:00h | UTCZolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)
News Release: Results from Astellas’ Phase 3 SPOTLIGHT Trial of Investigational Zolbetuximab Published in The Lancet – PR Newswire
Cohort Study | Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer
17 Apr, 2023 | 12:57h | UTCCancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: Endoscopic Surveillance in Patients at Risk for Hereditary Diffuse Gastric Cancer – The ASCO Post
M-A | Efficacy of postpartum pharmacologic thromboprophylaxis
17 Apr, 2023 | 12:55h | UTC
RCT | Safety of Fezolinetant for vasomotor symptoms associated with menopause
17 Apr, 2023 | 12:54h | UTCRelated:
RCT | Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause
RCT | Efficacy of Fezolinetant in moderate-to-severe vasomotor symptoms associated with menopause
The earlier the better: an RCT of treatment timing effects for toddlers on the autism spectrum
17 Apr, 2023 | 12:52h | UTC
RCT | 10-year results show low-dose tamoxifen reduces noninvasive breast cancer recurrence
17 Apr, 2023 | 12:50h | UTCRandomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study – Journal of Clinical Oncology (link to abstract – $ for full-text)
RCT | Hydroxyurea for secondary stroke prevention in children with sickle cell anemia
17 Apr, 2023 | 12:48h | UTC
SR | Blood pressure control for diabetic retinopathy
17 Apr, 2023 | 12:45h | UTCBlood pressure control for diabetic retinopathy – Cochrane Library
Summary: Blood pressure control for diabetic retinopathy – Cochrane Library
SR | Device‐modified trabeculectomy for glaucoma
17 Apr, 2023 | 12:46h | UTCDevice‐modified trabeculectomy for glaucoma – Cochrane Library
Summary: Device-modified trabeculectomy for glaucoma – Cochrane Library
SR | Exercise‐based rehabilitation programs for pulmonary hypertension
17 Apr, 2023 | 12:44h | UTCExercise‐based rehabilitation programmes for pulmonary hypertension – Cochrane Library
Summary: Exercise-based rehabilitation in pulmonary hypertension – Cochrane Library
SR | Mechanical methods for induction of labor
17 Apr, 2023 | 12:42h | UTCMechanical methods for induction of labour – Cochrane Library
Summary: Mechanical methods for induction of labour – Cochrane Library
SR | Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease
17 Apr, 2023 | 12:40h | UTC