Daily Archives: April 6, 2023 | LinksMedicus Free Medical News & Perspectives

New content online: Global epidemiology of cirrhosis — aetiology, trends and predictions https://t.co/EbgDWTjOyI pic.twitter.com/Cj7KFoWtLi

— Nature Reviews Gastroenterology & Hepatology (@NatRevGastroHep) March 28, 2023

RCT | Routine invasive approach fails to benefit frail older adults with non–ST-segment elevation acute myocardial infarction

6 Apr, 2023 | 13:23h | UTC

Effect of Routine Invasive vs Conservative Strategy in Older Adults With Frailty and Non–ST-Segment Elevation Acute Myocardial Infarction: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Routine invasive strategy not associated with improved outcomes in older adults with frailty and non-ST segment elevation acute myocardial infarction – Physician’s Weekly

Commentary on Twitter

A routine invasive strategy did not improve clinical outcomes in frail patients with NSTEMI. Future trials should confirm whether a policy of watchful observation rather than routine invasive management may be effective for these patients. https://t.co/N4hAXg5fid

— JAMA Internal Medicine (@JAMAInternalMed) March 6, 2023

Review | Post-COVID syndrome

6 Apr, 2023 | 13:21h | UTC

Post-COVID Syndrome – Deutsches Ärzteblatt International

Cohort Study | One third of patients hospitalized with Covid-19 persist with lung abnormalities after 2 years

Long COVID: major findings, mechanisms and recommendations – Nature Reviews Microbiology

ESMO Guideline | Updated treatment recommendations for prostate cancer

6 Apr, 2023 | 13:18h | UTC

Updated treatment recommendations for prostate cancer from the ESMO Clinical Practice Guideline considering treatment intensification and use of novel systemic agents – Annals of Oncology

Guideline | Muscle-invasive and metastatic bladder cancer

6 Apr, 2023 | 13:19h | UTC

Muscle-invasive and Metastatic Bladder Cancer – European Association of Urology (see PDF)

Rheumatic heart disease: JACC focus seminar

6 Apr, 2023 | 13:17h | UTC

Rheumatic Heart Disease: JACC Focus Seminar – Journal of the American College of Cardiology

Infections and cardiovascular disease: JACC focus seminar

6 Apr, 2023 | 13:15h | UTC

Infections and Cardiovascular Disease: JACC Focus Seminar 1/4 – Journal of the American College of Cardiology

Review | De-escalation of antiplatelet therapy in patients with coronary artery disease: time to change our strategy?

6 Apr, 2023 | 13:14h | UTC

De-escalation of antiplatelet therapy in patients with coronary artery disease: Time to change our strategy? – European Journal of Internal Medicine

Podcast | Congenital hypothyroidism

6 Apr, 2023 | 13:11h | UTC

#78: Congenital Hypothyroidism – The Cribsiders

Podcast | HIV in primary care

6 Apr, 2023 | 13:13h | UTC

#388 HIV in Primary Care with Dr. Jonathan J. “JJ” Nunez MD – The Curbsiders

Podcast | Childhood-Onset SLE

6 Apr, 2023 | 13:12h | UTC

#77: Childhood-Onset SLE – Is It Sometimes Lupus? – The Cribsiders

Cohort Study | Barriers to starting direct-acting antiviral treatment despite access for HIV & hepatitis C patients

6 Apr, 2023 | 13:09h | UTC

Reasons for not commencing direct-acting antiviral treatment despite unrestricted access for individuals with HIV and hepatitis C virus: a multinational, prospective cohort study – The Lancet Public Health

Invited Commentary: The road to hepatitis C virus elimination – The Lancet Public Health

RCT | Safety and efficacy of Pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy

6 Apr, 2023 | 13:08h | UTC

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Pitolisant Improves Pediatric Narcolepsy Symptoms Regardless of Cataplexy in Phase 3 Study – Neurology Live

SR | Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years

6 Apr, 2023 | 13:06h | UTC

Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years – Cochrane Database of Systematic Reviews

Summary: Is zinc supplementation effective for preventing death and disease, and for promoting growth, in children aged 6 months to 12 years and does it cause unwanted effects? – Cochrane Database of Systematic Reviews

SR | Insufficient evidence on skin-sparing mastectomy efficacy and safety for breast cancer

6 Apr, 2023 | 13:04h | UTC

Skin‐sparing mastectomy for the treatment of breast cancer – Cochrane Database of Systematic Reviews

Summary: Is skin-sparing mastectomy an effective and safe surgical procedure for the treatment of breast cancer? – Cochrane Database of Systematic Reviews

M-A | Comparison of the diagnostic accuracies of monocyte distribution width, procalcitonin, and C-reactive protein for sepsis

6 Apr, 2023 | 13:00h | UTC

Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis – Critical Care Medicine

Cohort Study | Maternal cardiac arrest: occurrence, survival, and influencing factors

6 Apr, 2023 | 12:59h | UTC

Cardiac Arrest During Delivery Hospitalization: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Cardiac Arrest During Delivery Hospitalization – American College of Cardiology

Cardiac Arrest During Childbirth Is Rare, But Some Women Face Higher Risks – HealthDay

Commentary on Twitter

https://twitter.com/AnnalsofIM/status/1636095275545632768

Cohort Study | Multimodal prediction of favorable outcome after cardiac arrest

6 Apr, 2023 | 13:01h | UTC

Multimodal Prediction of Favorable Outcome After Cardiac Arrest: A Cohort Study – Critical Care Medicine

RCT | Over-the-scope clips show lower rebleeding rates in nonvariceal GI bleeding

6 Apr, 2023 | 12:57h | UTC

Comparison of Over-the-Scope Clips to Standard Endoscopic Treatment as the Initial Treatment in Patients With Bleeding From a Nonvariceal Upper Gastrointestinal Cause: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Over-the-Scope Clip Beneficial for Nonvariceal Upper GI Bleeding – HealthDay

Over-the-scope clips superior to standard treatment of nonvariceal upper GI bleeding – Physician’s Weekly

Commentary on Twitter

A new RCT found that over-the-scope-clips may be more effective than standard treatment for some patients with nonvariceal upper #GastrointestinalBleeding: https://t.co/GWG70CWmlt pic.twitter.com/Foq2qQZTEc

— Annals of Int Med (@AnnalsofIM) March 7, 2023

RCT | Etrasimod outperforms placebo in ulcerative colitis induction & maintenance

6 Apr, 2023 | 12:56h | UTC

Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies – The Lancet

Commentary on Twitter

Just published @TheLancet – Sandborn et al – Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies https://t.co/BVDWtESWLP #gitwitter #ibd #ulcerativecolitis #ECCO23 #ECCO2023 pic.twitter.com/hjyJ0tdtWd

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) March 3, 2023