Daily Archives: March 31, 2023 | LinksMedicus Free Medical News & Perspectives

Assessing heart failure risk: waist-to-height ratio outperforms BMI in HFrEF patients

31 Mar, 2023 | 13:49h | UTC

Anthropometric measures and adverse outcomes in heart failure with reduced ejection fraction: revisiting the obesity paradox – European Heart Journal

Editorial: Revisiting the obesity paradox in heart failure: what is the best anthropometric index to gauge obesity? – European Heart Journal

News Release: Study shows ‘obesity paradox’ does not exist: waist-to-height ratio is a better indicator of outcomes in patients with heart failure than BMI – European Society of Cardiology

Commentary: Study Debunks Obesity Paradox in HF, Encourages BMI Alternatives – TCTMD

RCT | Early postpartum IUD placement noninferior vs. placement at 6-8 weeks for complete expulsion, but not for partial expulsion

31 Mar, 2023 | 13:48h | UTC

Early vs Interval Postpartum Intrauterine Device Placement: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

News Release: Study: Risk of IUD Expulsion in Early Postpartum Placement – UC San Diego Health

Commentary: IUD Placement at Two to Four Weeks Postpartum Noninferior – HealthDay

Placement of an intrauterine device within 48 hours after early medical abortion – a randomized controlled trial – American Journal of Obstetrics & Gynecology

Commentary on Twitter

Early IUD placement at 2 to 4 weeks postpartum compared with 6 to 8 weeks postpartum was noninferior for complete expulsion, but not partial expulsion. https://t.co/VMfWce3JJd pic.twitter.com/vdLrhCXa5Q

— JAMA (@JAMA_current) March 23, 2023

SCAI/HRS Expert consensus statement on transcatheter left atrial appendage closure

31 Mar, 2023 | 13:44h | UTC

SCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure – JSCAI

Key Points: Consensus Statement on Transcatheter LA Appendage Closure – American College of Cardiology

Commentaries:

SCAI/HRS Consensus Document Covers the Ins and Outs of LAAO – TCTMD

New SCAI/HRS Expert Consensus Statement Addresses Transcatheter LAAC – American College of Cardiology

M-A | Effects of statin therapy on glycemic control and insulin resistance

31 Mar, 2023 | 13:45h | UTC

Effects of statin therapy on glycemic control and insulin resistance: A systematic review and meta-analysis – European Journal of Pharmacology

Meta-Analysis: Medications that Reduce or Increase the Risk of New Onset Diabetes

Observational Study Points to an Increased Risk of Diabetes Among Patients Using Statins

Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus

Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes

Study shows clinical instability and severity are predictors for psychiatric hospitalization

31 Mar, 2023 | 13:42h | UTC

Predicting Psychiatric Admissions: The Role of Early Clinical Trajectories Across Diagnoses – The Lancet Psychiatry

Commentaries:

New study reveals clinical instability predicts psychiatric hospitalization – MedicalXpress

Instability, Clinical Severity Predict Hospitalization Risk for Psychiatric Illness – HCP Live

Update | Optimal oxygen and mean arterial blood pressure targets after cardiac arrest

31 Mar, 2023 | 13:41h | UTC

Optimal oxygen and mean arterial blood pressure targets after cardiac arrest – Intensive Care Medicine

Commentary on Twitter

O2/MAP after CA? NO clear benefit from deviating from
?MAP >65-70 mmHg, if impaired ?autoregulation as high as 85-90
? PaO2 75-97 mmHg; more liberal O2 may be best if reliable monitoring difficult (ie transport or in ED)
More evidence needed (coming)
?️ https://t.co/ujsz09tDSJ pic.twitter.com/fft8Q1turt

— Intensive Care Medicine (@yourICM) March 21, 2023

M-A | Incidence and prognostic role of pleural effusion in patients with pulmonary embolism

31 Mar, 2023 | 13:40h | UTC

Incidence and Prognostic Role of Pleural Effusion in Patients with Pulmonary Embolism: A Systematic Review and Meta-Analysis – Journal of Clinical Medicine

SR | Etiologies of vertigo in the elderly

31 Mar, 2023 | 13:38h | UTC

Vertigo in the Elderly: A Systematic Literature Review – Journal of Clinical Medicine

RCT | Comparing exemestane dose regimens in early-stage ER+ breast cancer

31 Mar, 2023 | 13:37h | UTC

Efficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor–Positive Breast Cancer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Lower-Dose Regimens of Exemestane in Postmenopausal Patients With Stage 0 to II ER-Positive Breast Cancer – The ASCO Post

Commentary on Twitter

Exemestane 25 mg (Exe) 3x/week (TIW) in compliant patients is comparable to daily dosing in reducing circulating estradiol; a weekly dose was less effective. Toxicity similar in all arms, suggesting Exe TIW may be used in breast cancer prevention. https://t.co/2NugINVrim #BCS

— JAMA Oncology (@JAMAOnc) March 23, 2023

Cohort Study | Subclinical coronary atherosclerosis and risk for myocardial infarction

31 Mar, 2023 | 13:36h | UTC

Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort: A Prospective Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: CTA-detected coronary artery disease associated with increased risk for myocardial infarction – ACP Internist

New study challenges the idea that a coronary artery calcium score of 0 is enough for ruling out coronary stenosis in symptomatic patients, especially in young adults.

Cohort Study: Coronary Artery Calcium and Long-Term Risk of Death, Myocardial Infarction, and Stroke

USPSTF Statement: Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors

Research: Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome

The 10-Year Prognostic Value of Zero and Minimal CAC

Review | Exercise in octogenarians: how much is too little?

31 Mar, 2023 | 13:34h | UTC

Exercise in Octogenarians: How Much Is Too Little? – Annual Reviews of Medicine

Cohort Study | Diffusing capacity strongly predicts all-cause mortality in individuals with COPD

31 Mar, 2023 | 13:31h | UTC

Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentary: Diffusing capacity ‘strongly predicted’ mortality in COPD patients – Healio (free registration required)

Commentary on Twitter

Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease

? https://t.co/F5Hqkx65hn pic.twitter.com/up0psKKE3i

— Annals of the ATS (@AnnalsATS) January 10, 2023

RCT | Pulsed oral azithromycin vs. 6-week oral doxycycline for moderate to severe meibomian gland dysfunction

31 Mar, 2023 | 13:33h | UTC

Pulsed Oral Azithromycin vs 6-Week Oral Doxycycline for Moderate to Severe Meibomian Gland Dysfunction: A Randomized Clinical Trial – JAMA Ophthalmology (link to abstract – $ for full-text)

Commentary: 3-Week MGD treatment equivalent to 6-week course in efficacy and adverse events – Ophthalmology Times

Commentary on Twitter

A 3-week course of weekly oral azithromycin was equivalent to a 6-week course of oral doxycycline in treating moderate to severe meibomian gland dysfunction. https://t.co/nE312KxGki pic.twitter.com/xWmqYWby7j

— JAMA Ophthalmology (@JAMAOphth) March 23, 2023

M-A | Impact of axillary lymph node dissection and sentinel lymph node biopsy on upper limb morbidity in breast cancer patients

31 Mar, 2023 | 13:30h | UTC

Impact of Axillary Lymph Node Dissection and Sentinel Lymph Node Biopsy on Upper Limb Morbidity in Breast Cancer Patients: A Systematic Review and Meta-Analysis – Annals of Surgery

SR | Nonopioid pharmacological management of acute low back pain

31 Mar, 2023 | 13:27h | UTC

Nonopioid pharmacological management of acute low back pain: A level I of evidence systematic review – Journal of Orthopaedic Research

Review | The failed peripheral nerve block

31 Mar, 2023 | 13:28h | UTC

The failed peripheral nerve block – BJA Education

RCT | Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention

31 Mar, 2023 | 13:26h | UTC

Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention (VANGUARD): a global, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter (thread – click for more)

Hereditary angioedema is a rare disease associated with unpredictable, recurrent angioedema attacks that can be life-threatening.

New study data support the use of garadacimab as a potential prophylactic therapy in adolescents and adults: https://t.co/xlxoA3J3sh ? pic.twitter.com/VqCOHnaQAp

— The Lancet (@TheLancet) March 6, 2023