Daily Archives: March 16, 2023
FDA issues new information on cases of squamous cell carcinoma and lymphomas around breast implants
16 Mar, 2023 | 13:28h | UTCSummary: The US Food and Drug Administration (FDA) has provided an update on reports of squamous cell carcinoma (SCC) in the scar tissue (capsule) that forms around breast implants. The FDA is aware of 19 cases of SCC in the capsule around the breast implant from published literature, including 3 reports of deaths from the disease.
While the FDA continues to believe that occurrences of SCC in the capsule around the breast implant may be rare, the cause, incidence, and risk factors remain unknown. Health care providers and people who have or are considering breast implants should be aware that cases of SCC and various lymphomas in the capsule around the breast implant have been reported to the FDA and in the literature.
The FDA continues to ask health care providers and people with breast implants to report cases of SCC, lymphomas, or any other cancers around breast implants.
FDA Safety Communication: Reports of Squamous Cell Carcinoma (SCC) in the Capsule Around Breast Implants – FDA Safety Communication – U.S. Food & Drug Administration
Related:
FDA Report: 660 Cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Study: Long-term Outcomes of Silicone Breast Implants
RCT | Pre-hospital rule-out of NSTE-ACS by ambulance paramedics with point-of-care troponin is feasible and cost-saving
16 Mar, 2023 | 13:27h | UTCSummary: Using a point-of-care (POC) troponin measurement, this randomized trial in the Netherlands assessed the safety and healthcare costs of a pre-hospital rule-out strategy for patients with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS).
The study included only patients considered at low risk with a HEAR (History, ECG, Age, Risk factors) score ≤3. A total of 863 low-risk participants were randomized to direct transfer to the ED or a pre-hospital rule-out strategy with POC troponin measurement.
The trial found that pre-hospital rule-out of NSTE-ACS in low-risk patients using a single POC troponin measurement is feasible, significantly reduces healthcare costs, and is associated with a low incidence of major adverse cardiac events.
The HEAR score, combined with a POC troponin measurement by ambulance paramedics, accurately identifies low-risk patients for whom ED evaluation is unnecessary. Implementing this pre-hospital rule-out strategy in low-risk patients could significantly reduce healthcare costs through more efficient use of ambulance services and fewer ED visits. It is worth noting, however, that further studies in other localities are necessary before the widespread use of this strategy can be implemented.
Commentaries:
JC: Can we rule out ACS by a single prehospital troponin measurement? – St. Emyln’s
Rule-Out of NSTE-ACS by a Prehospital Troponin Measurement – American College of Cardiology
RCT | Preliminary study suggests early methylene blue administration reduces vasopressor duration in septic shock patients
16 Mar, 2023 | 13:25h | UTCSummary: The study aimed to evaluate the efficacy and safety of early adjunctive methylene blue (MB) administration in patients with septic shock. In this single-center randomized controlled trial, 91 patients were randomly assigned to receive MB or placebo, with the primary outcome being the time to vasopressor discontinuation at 28 days.
The study found that the MB group had a significantly shorter time to vasopressor discontinuation, one more day of vasopressor-free days at day 28, a shorter length of stay in the ICU and hospital, and no serious adverse effects related to MB administration.
However, the study was limited by its small sample size and single-center design. Therefore, larger multicenter randomized clinical trials are needed to confirm the potential benefit of MB as an early adjunctive therapy in patients with septic shock.
International consensus statement on allergy and rhinology: allergic rhinitis
16 Mar, 2023 | 13:19h | UTC
Consensus Paper | Small intestinal bacterial overgrowth in gastrointestinal disorders
16 Mar, 2023 | 13:23h | UTC
AACC Guidance document on cervical cancer detection: screening, surveillance, and diagnosis
16 Mar, 2023 | 13:21h | UTC
Review | Evidence-based approach to diagnosis and management of abdominal tuberculosis
16 Mar, 2023 | 13:17h | UTCEvidence-based approach to diagnosis and management of abdominal tuberculosis – Indian Journal of Gastroenterology (if the link is paywalled, try this one)
Commentary from the author on Twitter
Our review on abdominal tuberculosis, where we summarise all the evidence on gastrointestinal tuberculosis and peritoneal tuberculosis, has been published in @ijg_journal
Great effort by @JhaDayakrishna and @menon_mythilihttps://t.co/spPXILGNw2 pic.twitter.com/SxnGs0n9DE— Vishal Sharma (@drvishal82) March 11, 2023
Guidelines on male adult testosterone deficiency, with statements for practice
16 Mar, 2023 | 13:18h | UTC
M-A | Maternal and infant outcomes of pregnancy associated with anti-SSA/RO antibodies
16 Mar, 2023 | 13:15h | UTC
Advantages and challenges of using telehealth for home-based palliative care | Systematic mixed studies review
16 Mar, 2023 | 13:14h | UTC
RCT | Impact of two ketogenic diet types in refractory childhood epilepsy
16 Mar, 2023 | 13:13h | UTCImpact of two ketogenic diet types in refractory childhood epilepsy – Pediatric Research
Related:
Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Safety, Efficacy, and Tolerability of Modified Atkins Diet in Persons With Drug-Resistant Epilepsy: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)
M-A | Low-intensity follow-up after cancer surgery does not reduce patient satisfaction or well-being
16 Mar, 2023 | 13:10h | UTCOncological surgery follow-up and quality of life: meta-analysis – British Journal of Surgery
Review | Improving vasopressor use in cardiac arrest
16 Mar, 2023 | 13:08h | UTCImproving vasopressor use in cardiac arrest – Critical Care
Study identifies outpatient procedures associated with increased risk of myocardial infarction
16 Mar, 2023 | 13:11h | UTCRisk of myocardial infarction after invasive outpatient procedures – Heart
M-A | Active fluid de-resuscitation in critically ill patients with septic shock
16 Mar, 2023 | 13:09h | UTC
Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum
16 Mar, 2023 | 13:05h | UTCNews Release: Researchers Identify blood panel to predict placenta accreta – Brigham and Women’s Hospital
RCT | Overall survival with Daratumumab, Lenalidomide, and Dexamethasone in previously treated multiple myeloma
16 Mar, 2023 | 13:07h | UTCOriginal Study: Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma – New England Journal of Medicine
M-A | Endoscopic surgery for spontaneous supratentorial intracerebral hemorrhage
16 Mar, 2023 | 13:04h | UTC
RCT | Insulin degludec is noninferior to insulin detemir for the treatment of pregnant women with type 1 diabetes
16 Mar, 2023 | 12:59h | UTCInsulin degludec versus insulin detemir, both in combination with insulin aspart, in the treatment of pregnant women with type 1 diabetes (EXPECT): an open‑label, multinational, randomised, controlled, non-inferiority trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Global validation of the AO Spine Upper Cervical Injury Classification
16 Mar, 2023 | 12:58h | UTCGlobal Validation of the AO Spine Upper Cervical Injury Classification – Spine
RCT | Intra-articular 10 mg triamcinolone acetonide non-inferior to 40 mg for knee osteoarthritis pain relief
16 Mar, 2023 | 12:55h | UTC
Primary myelofibrosis | 2023 update on diagnosis, risk-stratification, and management
16 Mar, 2023 | 12:57h | UTC
Cohort Study | Risk of interpersonal violence during and after pregnancy among people with schizophrenia
16 Mar, 2023 | 12:56h | UTCNews Release: Pregnant people with schizophrenia have threefold risk of interpersonal violence – Canadian Medical Association Journal