Daily Archives: March 2, 2023

The European guideline on management of major bleeding and coagulopathy following trauma

2 Mar, 2023 | 13:04h | UTC

The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition – Critical Care

Cohort Study | Female hormone therapy and risk of intracranial hemorrhage from cerebral cavernous malformations

2 Mar, 2023 | 13:03h | UTC

Summary: The study aimed to investigate the association between female hormone therapy (oral contraception or menopausal hormone therapy) and intracranial hemorrhage in female patients with cerebral cavernous malformations (CCM) using data from 2 large prospective cohort studies. The researchers analyzed data from 722 female patients with CCM and found that female hormone therapy use was associated with an increased risk of subsequent intracranial hemorrhage. The risk was more significant among female patients aged 10-44 years using oral contraceptives (adjusted hazard ratio 2·00, 95% CI 1·26-3·17; p=0·003). These findings raise questions about the safety of female hormone therapy in patients with cerebral cavernous malformation.

Article: Female Hormone Therapy and Risk of Intracranial Hemorrhage From Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study – Neurology (link to abstract – $ for full-text – you can try this link for full-text)

Commentary: Oral Contraceptive Use Raises Risk of Intracranial Hemorrhage in Young Females with Cerebral Cavernous Malformations – NeurologyToday

Youth-onset type 2 diabetes: the epidemiology of an awakening epidemic

2 Mar, 2023 | 13:01h | UTC

Youth-Onset Type 2 Diabetes: The Epidemiology of an Awakening Epidemic – Diabetes Care

M-A | Thromboprophylaxis in patients with Fontan circulation

2 Mar, 2023 | 12:57h | UTC

Thromboprophylaxis in Patients With Fontan Circulation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Thromboprophylaxis in Patients With Fontan Circulation – American College of Cardiology

Commentary from the author on Twitter (thread – click for more)

🔥Hot off the press🔥Read our new paper about #Thromboprophylaxis in patients with #Fontan #circulation just published in @JACCJournals @ACCinTouch.
Article link: https://t.co/eeu6kT7PDH

— Jef Van den Eynde (@JefVandenEynde) January 23, 2023

RCT | Empagliflozin (SGLT2i) is more effective for reducing HbA1c than linagliptin (DPP-4i) in young people with Type 2 DM

2 Mar, 2023 | 13:00h | UTC

Efficacy and safety of the SGLT2 inhibitor empagliflozin versus placebo and the DPP-4 inhibitor linagliptin versus placebo in young people with type 2 diabetes (DINAMO): a multicentre, randomised, double-blind, parallel group, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries:

DINAMO: Empagliflozin shows promise for young people with type 2 diabetes – medwire News

Phase 3 trial finds oral empagliflozin provides safe glycemic control in children with type 2 diabetes – Joslin Diabetes Center

M-A | Prevalence and odds of depressive and anxiety disorders and symptoms in children and adults with alopecia areata

2 Mar, 2023 | 12:59h | UTC

Prevalence and Odds of Depressive and Anxiety Disorders and Symptoms in Children and Adults With Alopecia Areata: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentary: Anxiety, Depressive Disorder Prevalence Greater Among Alopecia Areata Patients – HCP Live

Cohort Study | Risk of endometrial polyps, hyperplasia, carcinoma, and uterine cancer after tamoxifen treatment in premenopausal women with breast cancer

2 Mar, 2023 | 12:56h | UTC

Risk of Endometrial Polyps, Hyperplasia, Carcinoma, and Uterine Cancer After Tamoxifen Treatment in Premenopausal Women With Breast Cancer – JAMA Network Open

Commentary: Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment – HealthDay

Commentary on Twitter

Use of tamoxifen as an adjuvant hormone therapy for breast cancer was associated with an increased risk of endometrial polyps, hyperplasia, carcinoma, and other uterine cancers in Korean premenopausal women. https://t.co/JqnKjemjoW

— JAMA Network Open (@JAMANetworkOpen) November 29, 2022

M-A | Incidence, indications, risk factors, and outcomes of emergency peripartum hysterectomy worldwide

2 Mar, 2023 | 12:54h | UTC

Incidence, Indications, Risk Factors, and Outcomes of Emergency Peripartum Hysterectomy Worldwide: A Systematic Review and Meta-analysis – Obstetrics & Gynecology

Cohort Study | IVF-conceived children have similar school-age educational outcomes as spontaneously conceived children

2 Mar, 2023 | 12:53h | UTC

School-age outcomes among IVF-conceived children: A population-wide cohort study – PLOS Medicine

News Release: No link between IVF-assisted conception and school-age childhood development outcomes, study says – University of Melborn

Commentary: IVF Not Tied to Worse Developmental, Educational Outcomes – HealthDay

Cohort Study | Risk factors for serious infections in ANCA-associated vasculitis

2 Mar, 2023 | 12:52h | UTC

Risk factors for serious infections in ANCA-associated vasculitis – Annals of the Rheumatic Diseases

Commentary from the author on Twitter

Just published in @ARD_BMJ (https://t.co/mZVZ7HZaLC) – risk of severe infections in #AAV. The prophylactic use of low-dose TMP/SMX may reduce this risk. A work I am really proud of. Many thanks to all my co-authors, especially to my friend @AKronbichler for his endless support!

— Balazs Odler (@odlerb) January 26, 2023

RCT | Effects of a respiratory distress symptom intervention for lung cancer breathlessness–cough–fatigue symptom cluster

2 Mar, 2023 | 12:51h | UTC

Respiratory distress symptom intervention for non-pharmacological management of the lung cancer breathlessness–cough–fatigue symptom cluster: randomised controlled trial – BMJ Supportive & Palliative Care

RCT | Impact of supplementation with milk–cereal mix during 6–12 months of age on growth at 12 months in Delhi, India

2 Mar, 2023 | 12:50h | UTC

Impact of supplementation with milk–cereal mix during 6–12 months of age on growth at 12 months: a 3-arm randomized controlled trial in Delhi, India – The American Journal of Clinical Nutrition

Commentary: High-protein supplementation improves linear growth in infants – 2 Minute Medicine

RCT | Electrostimulation with the Alpha-Stim AID device is not better than sham treatment in major depression

2 Mar, 2023 | 12:49h | UTC

Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial – The Lancet Psychiatry

Commentary: Active AID Device Not More Effective Than Sham at Improving Depressive Symptoms – Neurology Advisor

Mean systolic blood pressure above the control threshold in people with treated uncontrolled hypertension in 55 countries

2 Mar, 2023 | 12:48h | UTC

Mean systolic blood pressure above the control threshold in people with treated uncontrolled hypertension: a pooled, cross-sectional analysis of 55 national health surveys – eClinicalMedicine

SR | Trifocal intraocular lenses vs. bifocal intraocular lenses after cataract extraction among participants with presbyopia

2 Mar, 2023 | 12:46h | UTC

Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with presbyopia – Cochrane Library

Summary: Trifocal versus bifocal lenses implantation after cataract surgery – Cochrane Library

RCT | Addition of preoperative transversus abdominis plane block to multimodal analgesia in open gynecological surgery

2 Mar, 2023 | 12:43h | UTC

Addition of preoperative transversus abdominis plane block to multimodal analgesia in open gynecological surgery: a randomized controlled trial – BMC Anesthesiology

Cohort Study | Association between marked fetal heart rate variability and neonatal acidosis

2 Mar, 2023 | 12:44h | UTC

Association between marked fetal heart rate variability and neonatal acidosis: A prospective cohort study – BJOG

Commentary: Marked variability associated with twofold increased risk of neonatal acidosis: BJOG

Cohort Study | Lifetime traumatic brain injury and cognitive domain deficits in late life

2 Mar, 2023 | 12:45h | UTC

Lifetime Traumatic Brain Injury and Cognitive Domain Deficits in Late Life: The PROTECT-TBI Cohort Study – Journal of Neurotrauma (link to abstract – you can try this link for full-text)

News Release: Three or more concussions linked with worse brain function in later life – University of Exeter