Daily Archives: February 13, 2023
Recommended adult immunization schedule, United States, 2023
13 Feb, 2023 | 13:06h | UTCRecommended Adult Immunization Schedule, United States, 2023 – Annals of Internal Medicine
Commentary: Recommended 2023 Adult Immunization Schedule Published – HealthDay
Commentary on Twitter
The 2023 #ACIP schedule is out now with important changes to #COVID19 and pneumococcal vaccines, including recommendations for adults who have previously received PCV13 and PPSV23: https://t.co/QeErLZJFuZ pic.twitter.com/BR6aa1kNKi
— Annals of Int Med (@AnnalsofIM) February 10, 2023
RCT | Azithromycin reduces the risk of maternal sepsis or death in women planning a vaginal birth
13 Feb, 2023 | 13:02h | UTCAzithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Single-dose antibiotic prevents maternal sepsis and death – NIH News
Commentaries:
In large study, a single antibiotic dose slashed rate of sepsis in childbirth – STAT
Dose of azithromycin found to cut risk of maternal death, sepsis in childbirth – CIDRAP
RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events
13 Feb, 2023 | 12:59h | UTCTenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Updated child and adolescent immunization schedule, United States, 2023
13 Feb, 2023 | 13:05h | UTCChild and Adolescent Immunization Schedule by Age – Centers for Diseases Control and Prevention
See also: Recommended Childhood and Adolescent Immunization Schedule: United States, 2023 – Pediatrics
Commentary: Immunization Schedule for Children, Teens Updated for 2023 – HealthDay
RCTs | Endovascular therapy improves functional outcomes in large ischemic strokes, but increases bleeding and vascular complications
13 Feb, 2023 | 13:00h | UTCStudy 1: Trial of Endovascular Thrombectomy for Large Ischemic Strokes – New England Journal of Medicine (link to abstract – $ for full-text)
Study 2: Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct – New England Journal of Medicine (link to abstract – $ for full-text)
M-A | Tenecteplase vs. alteplase for treatment of acute ischemic stroke
13 Feb, 2023 | 12:57h | UTCRelated: Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Perspective | Five new realities in critical care for patients with cancer
13 Feb, 2023 | 12:53h | UTCFive new realities in critical care for patients with cancer – Intensive Care Medicine
Related:
Consensus Conference: Critically ill cancer patient’s resuscitation.
Raising awareness for time-limited trial discussion upon ICU triage and admission.
Commentary on Twitter
New realities in critical care for pts with cancer
1️⃣ serious illness no longer means end of life
2️⃣ novel cancer therapies: changing outcomes but creating new diseases
3️⃣ take fresh look at ARF
4️⃣ goals of care & time‑limited trial
5️⃣ look beyond #ICU
? https://t.co/ZRNQD6AMIw pic.twitter.com/5QoYVSq5Br— Intensive Care Medicine (@yourICM) February 10, 2023
Video | ChatGPT: will it transform the world of health care?
13 Feb, 2023 | 12:55h | UTCChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine
Related:
ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)
ChatGPT: five priorities for research – Nature
The path forward for ChatGPT in academia – Lumo’s Newsletter
ChatGPT is fun, but not an author – Science
Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature
ChatGPT listed as author on research papers: many scientists disapprove – Nature
Abstracts written by ChatGPT fool scientists
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
13 Feb, 2023 | 12:50h | UTCDeprescribing Medications Among Older Adults From End of Hospitalization Through Postacute Care: A Shed-MEDS Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Related:
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Commentary on Twitter
A randomized trial of patient-centered #deprescribing in the acute care setting reduced medication burden by 14% among older hospitalized patients that needed ongoing post-acute care. https://t.co/FJf53O00Cv #ShedMEDS #polypharmacy #LessIsMore #Geriatrics
— JAMA Internal Medicine (@JAMAInternalMed) February 9, 2023
The Lancet Series | Breastfeeding 2023
13 Feb, 2023 | 12:52h | UTCHomepage: Breastfeeding 2023 – The Lancet
Editorial: Unveiling the predatory tactics of the formula milk industry
Breastfeeding: crucially important, but increasingly challenged in a market-driven world
Marketing of commercial milk formula: a system to capture parents, communities, science, and policy
Commentaries:
Expert reaction to review of formula baby milk – Science Media Centre
Guideline | Barrett’s esophagus and stage 1 esophageal adenocarcinoma: monitoring and management
13 Feb, 2023 | 12:49h | UTC
Updated Guideline | Cardiovascular disease risk assessment and reduction, including lipid modification
13 Feb, 2023 | 12:47h | UTCRelated Guidelines:
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation
#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias
#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
Abbreviated lipid guidelines for clinical practice
13 Feb, 2023 | 12:46h | UTCOriginal Guidelines
#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias
#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
Related:
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation
Phase 2 RCT | Effects of Difelikefalin in notalgia paresthetica
13 Feb, 2023 | 12:42h | UTCPhase 2 Trial of Difelikefalin in Notalgia Paresthetica – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Phase 2 Trial Finds Difelikefalin Could Prove Useful in Notalgia Paresthetica – HCP Live
Difelikefalin Improves Itch Intensity in Notalgia Paresthetica – HealthDay
Commentary on Twitter
In a phase 2 trial in notalgia paresthetica, oral difelikefalin treatment resulted in modestly reduced itch as compared with placebo. https://t.co/MQMO7z4o0W pic.twitter.com/2iaCgb3c93
— NEJM (@NEJM) February 8, 2023
Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations
13 Feb, 2023 | 12:44h | UTC
RCT | Preliminary study on the effects of low-dose colchicine in patients undergoing non-CABG cardiac surgery
13 Feb, 2023 | 12:43h | UTC
Commentary on Twitter
✅Colchicine reduced cardiac injury after cardiac surgery
132 pts randomized to
?0.5 mg of colchicine or placebo in the perioperative periodColchicine compared with placebo
Cardiac makers⬇️
Atrial fibrillation⬇️ (few events, though)?https://t.co/c2mZmvj6kQ#CardioTwitter pic.twitter.com/N3DUjr1WsB
— Yuki Kotani, MD | 小谷 祐樹 (@YukiKotani5) February 8, 2023
RCT | Ide-cel (a CAR-T cell treatment) vs. standard regimens in relapsed and refractory multiple myeloma
13 Feb, 2023 | 12:41h | UTCIde-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Ide-Cel Beneficial in Relapsed, Refractory Multiple Myeloma – HealthDay
Ide-cel Improves PFS vs SOC in Relapsed/Refractory Multiple Myeloma – OncLive
RCT | Allo-HCT vs. standard consolidation chemotherapy in patients with intermediate-risk AML
13 Feb, 2023 | 12:40h | UTCAllogeneic Hematopoietic Cell Transplantation vs Standard Consolidation Chemotherapy in Patients With Intermediate-Risk Acute Myeloid Leukemia: A Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary on Twitter
Rand trial suggests pts with intermediate-risk AML & matched donor have a significantly improved disease free-survival with allo-HCT during first complete remission (69% vs. 40%) but similar overall surv w/consol chemo & allo HCT only after relapse. https://t.co/TJR9fqcYc9
— JAMA Oncology (@JAMAOnc) February 9, 2023
M-A | Complications of percutaneous tracheostomy in critically ill adults with obesity
13 Feb, 2023 | 12:37h | UTCComplication Rate of Percutaneous Dilatational Tracheostomy in Critically Ill Adults With Obesity: A Systematic Review and Meta-analysis – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)
US infant pertussis incidence trends before and after implementation of the maternal Tdap vaccine
13 Feb, 2023 | 12:38h | UTCUS Infant Pertussis Incidence Trends Before and After Implementation of the Maternal Tetanus, Diphtheria, and Pertussis Vaccine – JAMA Pediatrics (free for a limited period)
Commentary: Maternal Tdap Vaccination Protects Youngest Infants From Pertussis – HealthDay
Commentary on Twitter
Study findings suggest that maternal #Tdap vaccination is associated with a reduction in #pertussis among infants younger than 2 months, the strategy’s target age group. https://t.co/a5h3z2zXY2
— JAMA Pediatrics (@JAMAPediatrics) February 7, 2023
Brief Review | Double sequential external defibrillation for refractory ventricular fibrillation
13 Feb, 2023 | 12:35h | UTC
Commentary on Twitter
?Refractory Vfib
⚡️ vector change defibrillation
⚡️ double sequential external defibrillation
exciting & innovative strategies that can improve survival for patients presenting with refractory VF: time will tell if will be broadly implemented/embraced
?️ https://t.co/uUktOHdGEl pic.twitter.com/aiOtMMX2nT— Intensive Care Medicine (@yourICM) February 9, 2023
SR | Spin and fragility in randomized controlled trials in the anesthesia literature
13 Feb, 2023 | 12:33h | UTCSpin and fragility in randomised controlled trials in the anaesthesia literature: a systematic review – British Journal of Anaesthesiology (free for a limited period)
Using Risk of Bias 2 to assess results from randomized controlled trials: guidance from Cochrane
13 Feb, 2023 | 12:34h | UTC
Review | Advanced point-of-care bedside monitoring for acute respiratory failure
13 Feb, 2023 | 12:32h | UTCAdvanced Point-of-care Bedside Monitoring for Acute Respiratory Failure – Anesthesiology
Commentary on Twitter
Advanced respiratory monitoring involves several mini- or noninvasive tools, applicable at bedside, that have the potential to support clinicians in the management of acute respiratory failure. Learn more about the personalization of ventilatory strategy: https://t.co/RP4LAsdQHM pic.twitter.com/KFlwxDthe9
— Anesthesiology (@_Anesthesiology) February 10, 2023
Brief Review | Surgical management of ulcerative colitis
13 Feb, 2023 | 12:30h | UTCSurgical management of ulcerative colitis – British Journal of Surgery