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Daily Archives: November 11, 2022

M-A | SGLT2 inhibitors reduce the risk of kidney disease progression and AKI, irrespective of diabetes status.

11 Nov, 2022 | 14:04h | UTC

Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials – The Lancet

Commentaries:

Meta-analysis backs SGLT2 inhibitors for kidney disease – medwire News

EMPA-KIDNEY: Empagliflozin a ‘Win’ for Patients With CKD – TCTMD

Related: RCT | In patients with CKD (eGFR 20-45 mL/min per 1.73 m2), Empagliflozin reduced the risk of progression of kidney disease.

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) License

 

RCT | Indobufen vs. aspirin on top of clopidogrel after coronary drug-eluting stent implantation.

11 Nov, 2022 | 14:03h | UTC

Indobufen or Aspirin on Top of Clopidogrel after Coronary Drug-eluting Stent Implantation (OPTION): a Randomized, Open-label, Endpoint-blinded, Non-inferiority Trial – Circulation

 

Commentary on Twitter

 

RCT | Early routine use of ECMO fails to improve outcomes in patients with cardiogenic shock.

11 Nov, 2022 | 14:01h | UTC

Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial – Circulation

Commentaries:

Early use of ECMO devices to support adults with cardiogenic shock did not improve clinical outcomes – News Medical/American Heart Association

Early ECMO No Better Than Watch-and-Wait Approach in Cardiogenic Shock – TCTMD

Immediate Use of ECMO Did Not Improve Outcomes in Patients with Cardiogenic Shock – HCP Live

 

Commentary on Twitter

 

RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.

11 Nov, 2022 | 14:00h | UTC

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial – The Lancet

News Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham

 

Commentary on Twitter

 

RCT | Dual endothelin antagonist Aprocitentan is effective for resistant hypertension.

11 Nov, 2022 | 13:59h | UTC

Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentaries:

Endothelin Receptor Antagonist Effective in Resistant Hypertension: PRECISION – TCTMD

Parallel-Group, Phase 3 Study With Aprocitentan in Subjects With Resistant Hypertension – PRECISION – American College of Cardiology

 

RCT | Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer.

11 Nov, 2022 | 13:55h | UTC

[News release – not published yet] Shortened course of radiation therapy safe and effective for men with high-risk prostate cancer – American Society for Radiation Oncology (ASTRO) Annual Meeting

 

Phase 2RCT | Baxdrostat reduces BP in patients with treatment-resistant hypertension.

11 Nov, 2022 | 13:57h | UTC

Phase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Big Drops in Blood Pressure With Baxdrostat: BrigHTN Phase II Study – TCTMD

New Drug Helps Tame Uncontrolled High Blood Pressure – HealthDay

 

RCT | A small study tested Apixaban’s efficacy and safety versus a Vitamin K-antagonist in patients on chronic hemodialysis.

11 Nov, 2022 | 13:52h | UTC

A Randomized Controlled Trial Comparing Apixaban to the Vitamin K-antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 study – Circulation

Related Study: Apixaban for Patients with Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial – Circulation

 

RCT | Efficacy of Safinamide as add-on therapy to Levodopa in patients with Parkinson’s disease with motor fluctuations.

11 Nov, 2022 | 13:53h | UTC

The XINDI Study: A Randomized Phase III Clinical Trial Evaluating the Efficacy and Safety of Safinamide as Add-On Therapy to Levodopa in Chinese Patients with Parkinson’s Disease with Motor Fluctuations – CNS Drugs

 

SR | Biomarkers as point‐of‐care tests to guide use of antibiotics in people with acute respiratory infections in primary care.

11 Nov, 2022 | 13:47h | UTC

Biomarkers as point‐of‐care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care – Cochrane Library

 

SR | Not enough evidence for routine use of antifibrinolytic therapy (e.g., tranexamic acid) in aneurysmal subarachnoid hemorrhage.

11 Nov, 2022 | 13:50h | UTC

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage – Cochrane Library

 

RCT | No benefit from a model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients.

11 Nov, 2022 | 13:46h | UTC

Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial – Intensive Care Medicine

 

Commentary on Twitter

 

Phase 2b RCT | Efficacy and safety of Bepirovirsen in chronic Hepatitis B infection.

11 Nov, 2022 | 13:44h | UTC

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Matched cohort study | Long-term clinical and radiographic outcomes in patients with clinically isolated aortitis.

11 Nov, 2022 | 13:43h | UTC

Long-Term Clinical and Radiographic Outcomes in Patients With Clinically Isolated Aortitis – ACR Open Rheumatology

 

M-A | Cardiovascular safety of febuxostat and allopurinol in patients with gout.

11 Nov, 2022 | 13:41h | UTC

Cardiovascular safety of febuxostat and allopurinol in patients with gout: A meta-analysis – Frontiers in Pharmacology

 

Cohort Study | Association between dietary habits in midlife with dementia incidence over a 20-year period.

11 Nov, 2022 | 13:40h | UTC

Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period – Neurology (PDF)

News Release: Does the Mediterranean diet really decrease your risk of dementia? – American Academy of Neurology

Commentary: Study Casts Doubt on Mediterranean Diet’s Benefit to Brain – HealthDay

 

M-A | Head-to-head trials comparing sulfonylureas and low hypoglycemic risk antidiabetic drugs.

11 Nov, 2022 | 13:38h | UTC

Systematic review and meta-analysis of head-to-head trials comparing sulfonylureas and low hypoglycaemic risk antidiabetic drugs – BMC Endocrine Disorders

 

M-A | The response of subgroups of patients with schizophrenia to different antipsychotic drugs.

11 Nov, 2022 | 13:13h | UTC

The response of subgroups of patients with schizophrenia to different antipsychotic drugs: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter (thread – click for more)

 

Retrospective Cohort Study | Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons.

11 Nov, 2022 | 13:36h | UTC

Perinatal outcomes associated with ICP in twin pregnancies were worse than singletons: an almost 5-year retrospective cohort study – BMC Pregnancy and Childbirth

 

Single-arm P1/2 study | Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma.

11 Nov, 2022 | 13:05h | UTC

Iberdomide plus dexamethasone in heavily pretreated late-line relapsed or refractory multiple myeloma (CC-220-MM-001): a multicentre, multicohort, open-label, phase 1/2 trial – The Lancet Haematology (link to abstract – $ for full-text)

 

Commentaries on Twitter

 

SR | The availability, cost, and affordability of essential medicines for asthma and COPD in low- and middle-income countries.

11 Nov, 2022 | 13:04h | UTC

The availability, cost, and affordability of essential medicines for asthma and COPD in low-income and middle-income countries: a systematic review – The Lancet Global Health

Invited Commentary: Access to essential respiratory medications remains elusive in LMICs – The Lancet Global Health

 

Phase 2 RCT | Efficacy of Bemarituzumab in patients with FGFR2b-selected gastric or gastro-esophageal junction adenocarcinoma.

11 Nov, 2022 | 13:02h | UTC

Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Cohort Study | Premenopausal bilateral oophorectomy linked to increased risk of Parkinsonism and Parkinson Disease.

11 Nov, 2022 | 12:56h | UTC

Association of Premenopausal Bilateral Oophorectomy With Parkinsonism and Parkinson Disease – JAMA Network Open

News Release: Removal of Both Ovaries in Younger Women Associated with Increased Risk of Parkinson’s – Discovery’s Edge

 

RCT | Volatile anesthesia did not significantly reduce postoperative delirium compared to IV anesthesia in cardiac valve surgery.

11 Nov, 2022 | 12:59h | UTC

Volatile Versus Total Intravenous Anesthesia on Postoperative Delirium in Adult Patients Undergoing Cardiac Valve Surgery: A Randomized Clinical Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

 

Single-arm phase 1b study | Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma.

11 Nov, 2022 | 13:00h | UTC

Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial – The Lancet Oncology (link to abstract – $ for full-text)

 

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