Daily Archives: November 4, 2022
A multinational Delphi consensus to end the COVID-19 public health threat.
4 Nov, 2022 | 14:01h | UTCA multinational Delphi consensus to end the COVID-19 public health threat – Nature
Phase 2 RCT | Single-dose Psilocybin for a treatment-resistant episode of major depression.
4 Nov, 2022 | 13:57h | UTCSingle-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Largest trial to date shows that psilocybin reduces depression symptoms – King’s College London
Related:
Research: “Magic mushrooms” for treatment-resistant depression
Commentary on Twitter
A single 25-mg dose of psilocybin was more effective than a 1-mg dose at alleviating treatment-resistant depression over a period of 3 weeks. The effect was attenuated at 12 weeks. https://t.co/sM1mISArvb pic.twitter.com/9YRaxfcpNT
— NEJM (@NEJM) November 2, 2022
RCT | Once-weekly Semaglutide effective for weight loss in adolescents with obesity.
4 Nov, 2022 | 13:59h | UTCOnce-Weekly Semaglutide in Adolescents with Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents – medwire News
Trial Shows Weight-Loss Drug Works in Teens – HealthDay
Commentary on Twitter
In this trial, adolescents with obesity assigned to weekly subcutaneous semaglutide plus lifestyle intervention had a greater reduction in BMI than those who received lifestyle intervention alone. https://t.co/yiFseP38xa pic.twitter.com/uRqkFfon1s
— NEJM (@NEJM) November 2, 2022
RCT | Discontinuing RAS inhibitors in patients with advanced CKD did not result in a slower decline in eGFR.
4 Nov, 2022 | 13:55h | UTCRenin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR. #KidneyWk https://t.co/81EIwG5FQ0 pic.twitter.com/nHNmzlPbHV
— NEJM (@NEJM) November 3, 2022
Perspective | Monkeypox — A sobering sentinel for pandemic preparedness and sexual health system capacity.
4 Nov, 2022 | 13:53h | UTCRelated:
Monkeypox – New England Journal of Medicine
Monkeypox: disease epidemiology, host immunity and clinical interventions.
Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health
CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.
Update on the Monkeypox Outbreak – JAMA
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Commentary on Twitter
The monkeypox pandemic has highlighted lessons learned — and sometimes ignored — from Covid-19 and has illustrated the inadequacy of sexual health infrastructure and pandemic preparedness in the United States. https://t.co/jXuYoH9Wn2 pic.twitter.com/KcTqBuyEXi
— NEJM (@NEJM) November 2, 2022
Cohort Study | Covid-19 vaccine effectiveness among children and adolescents in Qatar.
4 Nov, 2022 | 13:51h | UTC
Commentary on Twitter
The 10-µg dose of BNT162b2 led to modest, rapidly waning protection against Covid-19 in children 5 to 11 years old. The 30-µg dose in adolescents gave greater, more durable protection; more so in 12-to-14-year-olds than in 15-to-17-year-olds. https://t.co/ddcqiR8jvO pic.twitter.com/M8oSFYoFlw
— NEJM (@NEJM) November 2, 2022
M-A | Blood pressure lowering and prevention of dementia.
4 Nov, 2022 | 13:46h | UTCNews Release: Best evidence yet that lowering blood pressure can prevent dementia – George Institute for Global Health
Commentary: Meta-Analysis Shows Decrease in Dementia Risk With HTN Treatment – HealthDay
RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.
4 Nov, 2022 | 13:49h | UTC
Guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice.
4 Nov, 2022 | 13:42h | UTCExecutive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice – Rheumatology
RCT | Oral antimicrobial prophylaxis reduced surgical site infection after elective colorectal surgery.
4 Nov, 2022 | 13:48h | UTC
Guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids.
4 Nov, 2022 | 13:44h | UTCExecutive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids – Rheumatology
Consensus Paper | Atypical hemolytic uremic syndrome.
4 Nov, 2022 | 13:40h | UTC
Brief Review | Close collaboration between pathologists and intensivists to understand (not just) coronavirus disease.
4 Nov, 2022 | 13:37h | UTC
Commentary on Twitter
Pathologists & intensivists collaborating to understand (not just) #COVID19
➡️ facing an unknown entity: challenge in #ICU
➡️ lightening pathophysiological shadow: demand for autopsies
➡️ formalizing interdisciplinary exchange to optimize outcome#FOAMcc
?️https://t.co/0a48Vontzn pic.twitter.com/K9zTl5b8vp— Intensive Care Medicine (@yourICM) November 2, 2022
Brief Review | The prediction of fluid responsiveness.
4 Nov, 2022 | 13:39h | UTCThe prediction of fluid responsiveness – Intensive Care Medicine
Commentary on Twitter
Predicting fluid responsiveness in #ICU to avoid administration to patients who do not need & give when needed, allowing for truly personalized treatment
?fluids could be harmful
?fluids could be inconstantly effective#FOAMcc free to read on @yourICM
?️ https://t.co/os6seDVna2 pic.twitter.com/wy2wDVzfEA— Intensive Care Medicine (@yourICM) November 3, 2022
Cohort Study | Moderate to heavy drinking is linked to an increased risk of hemorrhagic stroke in young adults.
4 Nov, 2022 | 13:36h | UTCCumulative Alcohol Consumption Burden and the Risk of Stroke in Young Adults: A Nationwide Population-Based Study – Neurology (link to abstract – $ for full-text)
Commentaries:
Moderate-to-Heavy Drinking Linked to Stroke Risk in Young Adults – HealthDay
Moderate to heavy drinking could increase the risk of stroke in young adults – News Medical
RCT | Computerized games vs. crosswords training in mild cognitive impairment.
4 Nov, 2022 | 13:34h | UTCComputerized Games versus Crosswords Training in Mild Cognitive Impairment – NEJM Evidence
News Release: Crossword puzzles beat computer video games in slowing memory loss – Columbia University Irving Medical Center
Cohort Study | Fracture risk among older cancer survivors compared with older adults without a history of cancer.
4 Nov, 2022 | 13:33h | UTCFracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer – JAMA Oncology (free for a limited period)
Commentary: Frailty-Related Fracture Risk Higher for Seniors With Cancer History – HealthDay
Cohort Study | Low Apgar score and asphyxia complications at birth and risk of longer-term cardiovascular disease.
4 Nov, 2022 | 13:31h | UTCNews Release: Oxygen deprivation at birth could increase risk of cardiovascular disease – Karolinska Institutet
RCT | Brentuximab Vedotin with chemotherapy in pediatric high-risk Hodgkin’s Lymphoma.
4 Nov, 2022 | 13:30h | UTCBrentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin’s Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)
Review | Differing strategies for sudden death prevention in hypertrophic cardiomyopathy.
4 Nov, 2022 | 13:28h | UTCDiffering strategies for sudden death prevention in hypertrophic cardiomyopathy – Heart
Perspective | Teaching a deeper understanding of the medical literature.
4 Nov, 2022 | 13:26h | UTCTeaching a Deeper Understanding of the Medical Literature – Journal of General Internal Medicine
Heat-related illness in emergency and critical care: recognition and management with medico-legal considerations.
4 Nov, 2022 | 13:24h | UTCRelated:
Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine
Review | Inhaled corticosteroids in adults with non-cystic fibrosis bronchiectasis.
4 Nov, 2022 | 13:25h | UTC
M-A | Efficacy of neoadjuvant immunotherapy combined with chemotherapy for patients with resectable esophageal cancer.
4 Nov, 2022 | 13:22h | UTC
M-A | Migraine is linked to an increased risk of anxiety and depressive symptoms in children and adolescents.
4 Nov, 2022 | 13:20h | UTCAnxiety and Depressive Symptoms and Disorders in Children and Adolescents With Migraine: A Systematic Review and Meta-analysis – JAMA Pediatrics (Free for a limited period)
Editorial: Migraine and Mental Health in Pediatrics – Pediatrics (free for a limited period)
Commentary: Youth With Migraines Twice as Likely to Have Anxiety, Depression – Psychiatric News Alert