Daily Archives: October 17, 2022
Post-trial follow-up | Longer-term all-cause and cardiovascular mortality with intensive blood pressure control.
17 Oct, 2022 | 12:41h | UTCLonger-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
Author Interview: Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control – JAMA
Commentaries:
Benefits of Intensive Blood Pressure Control May Not Persist After Trial Intervention – HCP Live
Related:
Study: Real-world blood pressure measurements vs. measurements taken in the SPRINT trial
Studies: Intensive versus Standard Blood-Pressure Control
Commentary on Twitter
In a secondary analysis of SPRINT, the mortality benefits of intensive BP control attenuated after the trial, while outpatient systolic BP increased by an average of 7 mm Hg for participants in the intensive treatment group. https://t.co/INSo2zYzhp #Research
— JAMA Cardiology (@JAMACardio) October 12, 2022
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study.
17 Oct, 2022 | 12:39h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
Using the Burden of Proof analytical tool, a meta-analysis found weak or no evidence of associations between unprocessed #redmeat consumption and increased risk of six #cardiometabolic disease and #cancer outcomes. @IHME_UW https://t.co/3b7Sa9zCA1
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with vegetable consumption: a Burden of Proof study.
17 Oct, 2022 | 12:40h | UTCHealth effects associated with vegetable consumption: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof function identified modest evidence supporting a protective role of #vegetable consumption and #ischemicheartdisease, #stroke and esophageal cancer, but not type 2 #diabetes. @IHME_UW https://t.co/1w8OAELSvU
— Nature Medicine (@NatureMedicine) October 10, 2022
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study.
17 Oct, 2022 | 12:37h | UTCSee also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Health effects associated with smoking: a Burden of Proof study
Commentary on Twitter
A systematic review using the Burden of Proof meta-analytic method found a significant harmful effect between high systolic #bloodpressure and #ischemicheartdisease. @IHME_UW https://t.co/hewQ9nsCTh
— Nature Medicine (@NatureMedicine) October 10, 2022
Health effects associated with smoking: a Burden of Proof study.
17 Oct, 2022 | 12:36h | UTCHealth effects associated with smoking: a Burden of Proof study – Nature Medicine
See also:
Homepage: The Burden of Proof Studies – Nature Medicine
The Burden of Proof studies: assessing the evidence of risk
Health effects associated with vegetable consumption: a Burden of Proof study
Health effects associated with consumption of unprocessed red meat: a Burden of Proof study
Effects of elevated systolic blood pressure on ischemic heart disease: a Burden of Proof study
Commentary on Twitter
A meta-analysis using the Burden of Proof method reported consistent evidence supporting harmful associations between #smoking and 28 different #health outcomes. @IHME_UW https://t.co/0tEnMvTwG6
— Nature Medicine (@NatureMedicine) October 10, 2022
[Not published yet] Aspirin noninferior to LMW Heparin for prevention of death or pulmonary embolism after fracture surgery.
17 Oct, 2022 | 12:36h | UTC
Position Statement | Use of biomarkers for the management of heart failure and acute coronary syndrome.
17 Oct, 2022 | 12:34h | UTC
Consensus Paper | Follow-up strategies for patients with splenic trauma managed non-operatively.
17 Oct, 2022 | 12:35h | UTC
Guidelines for point-of-care ultrasound: part one (common heart and pulmonary applications).
17 Oct, 2022 | 12:32h | UTC
Isocitrate dehydrogenase mutant gliomas: consensus review on diagnosis, management, and future directions.
17 Oct, 2022 | 12:31h | UTC
Cohort Study | Visit-to-visit SBP variability linked to increased risk of atrial fibrillation in middle-aged and older populations.
17 Oct, 2022 | 12:30h | UTC
Special Issue | Antibiotic resistance in the ICU.
17 Oct, 2022 | 12:28h | UTCHomepage: Antibiotic Resistance
Editorial: Antibiotic Resistance
Antibiotic Stewardship in Critical and Emergency Care
Pharmacokinetic/Pharmacodynamic Principles to Combat Antimicrobial Resistance
Multidrug-Resistant Gram-Negative Bacteria in the ICU
Rapid Diagnostics and Antimicrobial Resistance in the ICU
Diagnostic Stewardship in Five Common Infectious Syndromes
Does Antimicrobial Resistance Affect Clinical Outcomes in the ICU?
Reducing Antibiotic Resistance in the ICU
Post-trial follow-up | Adjuvant Olaparib in patients with germline pathogenic variants in BRCA1/2 and high risk, early breast cancer.
17 Oct, 2022 | 12:27h | UTCOriginal Study: Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
OS from #OlympiA now out on Annals. After 3.5y of f-up, pts receiving adjuvant olaparib derived a significant OS benefit (4y Δ 3.4%, 89.8% vs 86.4%). No increased risk of MDS/AML with olaparib. Important to test for BRCA in potentially eligible patients.https://t.co/ygkr0cOwF0 pic.twitter.com/bg4Y2yyXwZ
— Paolo Tarantino (@PTarantinoMD) October 11, 2022
Images under a Creative Commons Attribution (CC BY 4.0) license
Fungal infections | Pathogenesis, antifungals and alternate treatment approaches.
17 Oct, 2022 | 12:24h | UTC
Commentary on Twitter
Fungal infections:
Pathogenesis, antifungals and alternate treatment approacheshttps://t.co/JMcmzsL3GA #OpenAccess pic.twitter.com/5xAi5IGRGf
— MicrobesInfect (@MicrobesInfect) April 27, 2022
Under a Creative Commons license
Single-arm phase 2 study | A less intensive treatment strategy may be effective for patients with stage IIA and stage IIB seminoma.
17 Oct, 2022 | 12:25h | UTCSingle-dose carboplatin followed by involved-node radiotherapy for stage IIA and stage IIB seminoma (SAKK 01/10): a single-arm, multicentre, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary: De-escalation Strategy in Seminoma: An Alternative Option? – Medscape (free registration required)
Commentary on Twitter
??
SAKK 01/10 results are out!! ??Stage IIA/B testicular seminoma➡️
1️⃣cycle of carboplatin+involved node RT
116 pts, median FU 4.5yrs
3yr PFS 93.7%, 7 relapses, all successfully salvaged. Seminoma-specific surv ?%
Generally well tolerated, gr3+tox chemo-related https://t.co/vI6ipafhZ8— Sophia Kamran, MD (@sophia_kamran) October 11, 2022
M-A | Association of atrial septal aneurysm and shunt size with stroke recurrence and benefit from patent foramen ovale closure.
17 Oct, 2022 | 12:24h | UTCAssociation of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence and Benefit From Patent Foramen Ovale Closure – JAMA Neurology (free for a limited period)
Commentary: Anatomic Features Key for Selecting Patients Best Suited to PFO Closure – TCTMD
Commentary on Twitter
Patients with both large shunt and atrial septal aneurysm (ASA) benefit substantially more from patent foramen ovale than patients with large shunt alone, small shunt and ASA, or neither large shunt or ASA. https://t.co/lYL5sOnTCW #Research
— JAMA Neurology (@JAMANeuro) October 11, 2022
A practical approach to the guideline-directed pharmacological treatment of heart failure with reduced ejection fraction.
17 Oct, 2022 | 12:15h | UTC
RCT | Adjuvant capecitabine following concurrent CTX-RT in locoregionally advanced nasopharyngeal carcinoma.
17 Oct, 2022 | 12:15h | UTC
Cohort Study | Diagnostic yield of ECG-gated cardiac CT in the acute phase of ischemic stroke vs. transthoracic echocardiography.
17 Oct, 2022 | 12:23h | UTCDiagnostic Yield of ECG-Gated Cardiac CT in theAcute Phase of Ischemic Stroke vsTransthoracic Echocardiography – Neurology (link to abstract – $ for full-text)
Author Interview: ECG-Gated Cardiac CT in Acute Ischemic Stroke vs Transthoracic Echocardiography
Commentary: Add Cardiac CT to Acute Stroke Imaging to Detect Cardioembolism -Medscape (free registration required)
Participation of older adults in clinical trials for new drug applications and biologics license applications from 2010-2019.
17 Oct, 2022 | 12:12h | UTC
Commentary on Twitter
Underrepresentation of adults above age 75-80 years found in evaluation of new medications. 60-75 year-olds were reasonably well represented in clinical trials in proportion to the prevalence data in the US. #OAResearch https://t.co/2RL5fTo3LA
— JAMA Network Open (@JAMANetworkOpen) October 14, 2022
Cohort Study | Incidence and survival in synchronous and metachronous liver metastases from colorectal cancer.
17 Oct, 2022 | 12:14h | UTC
RCT | Effect of front-of-package information, fruit imagery, and sugar warning labels on parent beverage choices for children.
17 Oct, 2022 | 12:11h | UTC
Commentary on Twitter
Front-of-pack "HIGH ADDED SUGARS" warnings that show added sugar content in teaspoons can lead parents to choose healthier drinks for their young children, even in the presence of fruit imagery and nutrient claims. #OAReaserch https://t.co/qNzt5lFIjO
— JAMA Network Open (@JAMANetworkOpen) October 13, 2022