Daily Archives: September 6, 2022 | LinksMedicus Free Medical News & Perspectives

Brief Review | Thromboprophylaxis in critical care.

6 Sep, 2022 | 14:41h | UTC

Thromboprophylaxis in critical care – Intensive Care Medicine

Review | Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome.

6 Sep, 2022 | 14:42h | UTC

Pulse oximetry for the diagnosis and management of acute respiratory distress syndrome – The Lancet Respiratory Medicine

Systematic Review | Probiotics for preventing acute upper respiratory tract infections.

6 Sep, 2022 | 14:40h | UTC

Probiotics for preventing acute upper respiratory tract infections – Cochrane Library

Commentary on Twitter

#probiotics for preventing colds? @CochraneARI looked at 24 studies w 6,950 people.
? may be beneficial in preventing at least 1 occurrence of acute upper respiratory tract infection #URTI & likely beneficial in preventing 3 occurrences of URTIs.https://t.co/A6XxrjKKcI pic.twitter.com/mDR3NYLLzQ

— The Cochrane Library (@CochraneLibrary) August 24, 2022

Study raises concerns about the effectiveness of the monkeypox vaccine.

6 Sep, 2022 | 14:39h | UTC

Study raises concerns about the effectiveness of the monkeypox vaccine – STAT

Original Study (Preprint): Low levels of monkeypox virus neutralizing antibodies after MVA-BN vaccination in healthy individuals – medRxiv

Study suggests AI improves chest X-ray interpretation.

6 Sep, 2022 | 14:38h | UTC

Commentary: Study Suggests AI Improves Chest X-Ray Interpretation – Diagnostic Imaging

Original Study: Association of Artificial Intelligence–Aided Chest Radiograph Interpretation With Reader Performance and Efficiency – JAMA Network Open

Commentary on Twitter

AI-aided interpretation improves reader performance and efficiency for identifying major thoracic findings on chest radiographs. @MGH_Webster #OpenAccess #Research https://t.co/JdgW55BgL7

— JAMA Network Open (@JAMANetworkOpen) August 31, 2022

Study finds high diagnostic concordance between telemedicine and in-person visits for most new clinical concerns.

6 Sep, 2022 | 14:37h | UTC

Assessment of Clinician Diagnostic Concordance With Video Telemedicine in the Integrated Multispecialty Practice at Mayo Clinic During the Beginning of COVID-19 Pandemic From March to June 2020 – JAMA Network Open

Commentary on Twitter

Provisional diagnosis established over video telemedicine visits matched the in-person reference standard diagnosis in 87% of cases in study of 2393 patients with video telemedicine consult followed by in-person outpatient visit within 90 days. #OAResearch https://t.co/4edJFQepZR

— JAMA Network Open (@JAMANetworkOpen) September 2, 2022

Consensus Statement | Cardiac screening prior to return to play after SARS-CoV-2 infection in the child and adolescent athlete. – “Asymptomatic individuals and those with mild symptoms should be cleared by their primary care or team physician, after physical examination and accurate evaluation of medical history”.

6 Sep, 2022 | 14:36h | UTC

Cardiac screening prior to return to play after SARS-CoV-2 infection: focus on the child and adolescent athlete: A Clinical Consensus Statement of the Task Force for Childhood Health of the European Association of Preventive Cardiology

M-A | Primary surgery vs. primary rehabilitation for treating anterior cruciate ligament injuries.

6 Sep, 2022 | 14:35h | UTC

Primary surgery versus primary rehabilitation for treating anterior cruciate ligament injuries: a living systematic review and meta-analysis – British Journal of Sports Medicine

News Release: Anterior cruciate ligament tear: Is an operation always necessary? – Judith Merkelt-Jedamzik, Hochschule für Gesundheit

RCT | Surgical reconstruction is superior to rehabilitation for patients with non-acute anterior cruciate ligament injury with persistent symptoms of instability.

Early surgical reconstruction versus rehabilitation with elective delayed reconstruction for patients with anterior cruciate ligament rupture: COMPARE randomised controlled trial – The BMJ

Commentary on Twitter

#NEW research: Surgery vs rehab for ACL injury ⚡️

What is the effectiveness of primary rehabilitation with optional surgical reconstruction compared to early surgical reconstruction for ACL rupture?

The findings are IN ?

READ HERE ➡️ https://t.co/EWkeMnHP3s pic.twitter.com/Y9qf07mT4l

— British Journal of Sports Medicine (BJSM) (@BJSM_BMJ) August 30, 2022

EPA Guidance on treatment of cognitive impairment in schizophrenia.

6 Sep, 2022 | 14:34h | UTC

EPA Guidance on treatment of cognitive impairment in schizophrenia – European Psychiatry (PDF)

Practice update to optimize the performance and interpretation of blood cultures.

6 Sep, 2022 | 14:31h | UTC

Practice update to optimize the performance and interpretation of blood cultures – South African Medical Journal

European recommendations on practices in pediatric neuroradiology.

6 Sep, 2022 | 14:33h | UTC

European recommendations on practices in pediatric neuroradiology: consensus document from the European Society of Neuroradiology (ESNR), European Society of Paediatric Radiology (ESPR) and European Union of Medical Specialists Division of Neuroradiology (UEMS) – Pediatric Radiology

Systematic Review | Opioid agonist treatment for people who are dependent on pharmaceutical opioids.

6 Sep, 2022 | 14:31h | UTC

Opioid agonist treatment for people who are dependent on pharmaceutical opioids – Cochrane Library

Summary: Opioid maintenance medicines for the treatment of dependence on opioid pain medicines – Cochrane Library

RCT | Among patients with inguinal hernia, pain with sexual activity is reduced similarly with total extraperitoneal repair without mesh fixation and Lichtenstein repair.

6 Sep, 2022 | 14:30h | UTC

Pain with sexual activity at 1 and 3 years: Comparing total extraperitoneal with Lichtenstein inguinal hernia repair in a randomized setting (TEPLICH trial) – Surgery

Commentary: Pain during sexual engagement improves among inguinal hernia patients after hernia repair – Medical Dialogues

Noninferiority RCT | Induction chemotherapy regimen of docetaxel plus cisplatin vs. docetaxel, cisplatin plus fluorouracil followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma.

6 Sep, 2022 | 14:29h | UTC

Induction chemotherapy regimen of docetaxel plus cisplatin versus docetaxel, cisplatin plus fluorouracil followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: Preliminary results of an open-label, noninferiority, multicentre, randomised, controlled phase 3 trial – eClinicalMedicine

RCT | Anatomical segmentectomy vs. standard lobectomy for non-small cell lung cancer up to 2 cm.

6 Sep, 2022 | 14:28h | UTC

Survival outcomes in a prospective randomized multicenter Phase III trial comparing patients undergoing anatomical segmentectomy versus standard lobectomy for non-small cell lung cancer up to 2 cm – Lung Cancer

A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation.

Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

A Meta-Analysis Comparing Lobectomy versus Segmentectomy in Stage I Non-Small Cell Lung Cancer – The Korean Journal of Thoracic and Cardiovascular Surgery

M-A | Safety and efficacy of abacavir for treating infants, children, and adolescents living with HIV.

6 Sep, 2022 | 14:27h | UTC

Safety and efficacy of abacavir for treating infants, children, and adolescents living with HIV: a systematic review and meta-analysis – The Lancet Child & Adolescent Health

Commentary on Twitter

*New meta-analysis* supports the use of #abacavir as a preferred first-line regimen for infants & children living with #HIV

By @jujesson & colleagueshttps://t.co/WSvp5ZOUf1 pic.twitter.com/qFBo5O3zJC

— The Lancet Child & Adolescent Health (@LancetChildAdol) September 5, 2022

Cohort Study | Associations between maternal antenatal corticosteroid treatment and psychological developmental and neurosensory disorders in children.

6 Sep, 2022 | 14:26h | UTC

Associations Between Maternal Antenatal Corticosteroid Treatment and Psychological Developmental and Neurosensory Disorders in Children – JAMA Network Open

Commentary: Toxicity of antenatal steroids on the developing brain – Neonatal Research

Commentary on Twitter

Maternal antenatal corticosteroid treatment-exposure, compared with nonexposure, was associated with higher rates of psychological development and neurosensory disorders in children followed from birth through 12 years of age. #OAResearch https://t.co/PuVSBTASze

— JAMA Network Open (@JAMANetworkOpen) August 24, 2022

Single-arm, phase 2 study | Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.

6 Sep, 2022 | 14:24h | UTC

Galunisertib plus neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer: a single-arm, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries:

Addition of Galunisertib to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer – The ASCO Post

Improved Complete Response Rate Observed With Galunisertib Plus Neoadjuvant CRT in Advanced Rectal Cancer – Cancer Network

RCT | Weekly Somapacitan is noninferior to daily GH in children with GH deficiency.

6 Sep, 2022 | 14:25h | UTC

Weekly Somapacitan is Effective and Well Tolerated in Children with GH Deficiency: The Randomized Phase 3 REAL4 Trial – The Journal of Clinical Endocrinology & Metabolism

Phase 2 RCT | Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease.

6 Sep, 2022 | 14:22h | UTC

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled, phase 2 study – The Lancet Respiratory Medicine

Commentary on Twitter

NEW Research—Pirfenidone slowed the rate of decline of FVC over time in patients with RA-ILD*

Being presented at #ERSCongress, ALERT 3 session, Sept 5 from 13:15 BST

From Joshua Solomon & colleagues https://t.co/Nu8wECECdD

*(please check study limitations) pic.twitter.com/IuRxLDZGd9

— The Lancet Respiratory Medicine (@LancetRespirMed) September 5, 2022

Review | Point-of-care ultrasound for the trauma anesthesiologist.

6 Sep, 2022 | 14:18h | UTC

Point-of-Care Ultrasound for the Trauma Anesthesiologist – Current Anesthesiology Reports

Review | Cardiovascular complications of immune checkpoint inhibitors for cancer.

6 Sep, 2022 | 14:20h | UTC

Cardiovascular complications of immune checkpoint inhibitors for cancer – European Heart Journal

Major Adverse Cardiac Events With Immune Checkpoint Inhibitors: A Pooled Analysis of Trials Sponsored by the National Cancer Institute—Cancer Therapy Evaluation Program – Journal of Clinical Oncology

Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment – Journal of the American Heart Association

Cardiotoxicity of immune checkpoint inhibitors – ESMO Open

Cardiotoxicity from immune checkpoint inhibitors – IJC Heart & Vasculature

Cardiovascular toxicity of immune checkpoint inhibitors in cancer patients: A review when cardiology meets immuno-oncology – Journal of the Formosan Medical Association

Immune-Checkpoint Inhibitor-Induced Fulminant Myocarditis and Cardiogenic Shock – JACC: CardioOncology

Commentary on Twitter

Must read state-of-the-art review: Cardiovascular complications of immune checkpoint inhibitors for cancer https://t.co/0lr7g6s8g0
#EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/jORaTzP7GD

— European Society of Cardiology Journals (@ESC_Journals) September 5, 2022