Daily Archives: June 13, 2022
BSH guideline for the hematological management of major hemorrhage.
13 Jun, 2022 | 10:53h | UTC
Case Series | Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit.
13 Jun, 2022 | 10:46h | UTCOutbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Related: Investigating acute hepatitis of unknown origin in children (several resources on the subject)
Commentary on Twitter
Outbreak of non-A-E hepatitis in children, ?? data. Good outcomes if ALF by dedicated liver #ICU with early referral to Tx centres, recognizing neuro-deterioration, high-volume #ECLS, close neuromonitoring/protection & support by hepatology/Tx physicians
?https://t.co/GYAMaZbVGD pic.twitter.com/GA58vJWQIz— Intensive Care Medicine (@yourICM) June 10, 2022
WHO Interim Guidance: Clinical management and infection prevention and control for monkeypox.
13 Jun, 2022 | 10:49h | UTCRelated:
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
M-A: Respiratory viral co-infections in patients with COVID-19 and associated outcomes.
13 Jun, 2022 | 10:41h | UTC
NIH Updated Guideline: Oxygenation and ventilation for adults with Covid-19.
13 Jun, 2022 | 10:44h | UTCOxygenation and Ventilation for Adults – National Institutes of Health
RCT: Emergency vs. delayed coronary angiogram in survivors of out-of-hospital cardiac arrest.
13 Jun, 2022 | 10:42h | UTCEmergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest: Results of the Randomized, Multicentric EMERGE Trial – JAMA Cardiology (free for a limited period)
Commentary on Twitter
In this RCT, performing an emergency coronary angiogram (CAG) after an out-of-hospital cardiac arrest without ST-segment elevation showed no difference in the 180-day survival rate compared to a delayed CAG. https://t.co/gYwPdNV32v
— JAMA Cardiology (@JAMACardio) June 8, 2022
RCT: Intramuscular tixagevimab–cilgavimab may benefit non-hospitalized unvaccinated adults with Covid-19.
13 Jun, 2022 | 10:39h | UTCCommentaries:
Safety and efficacy of tixagevimab–cilgavimab in preventing severe COVID – News Medical
Commentary on Twitter
NEW—A single intramuscular tixagevimab–cilgavimab dose provided protection against progression to severe COVID-19 or death vs placebo in unvaccinated individuals
TACKLE trial from Prof Hugh Montgomery & colleagues https://t.co/M9LENFsA2C pic.twitter.com/Aon4wJsBOi
— The Lancet Respiratory Medicine (@LancetRespirMed) June 8, 2022
Guidelines for the management of hypertension.
13 Jun, 2022 | 08:13h | UTC
One in 500 men carry extra sex chromosome, putting them at higher risk of several common diseases.
13 Jun, 2022 | 10:35h | UTCNews Release: One in 500 men carry extra sex chromosome, putting them at higher risk of several common diseases – University of Cambridge
Original Study: Detection and characterization of male sex chromosome abnormalities in the UK Biobank study – Genetics in Medicine
Commentary: One in 500 men carry extra sex chromosome, research suggests – The Guardian
Commentary on Twitter
Interesting work looking at the prevalence of male sex chromosomal abnormalities in UK Biobank.
"Only 49 of 213 (23%) of men whom we identified with KS and only 1 of 143 (0.7%) with 47,XYY had a diagnosis of abnormal karyotype on their medical records or self-report." https://t.co/3VKh2rqxyn
— Veera M. Rajagopal (@doctorveera) June 11, 2022
ESMO Guideline: Diagnosis, treatment, and follow-up of endometrial cancer.
13 Jun, 2022 | 08:08h | UTC
Position Statement: Management of diabetic kidney disease.
13 Jun, 2022 | 08:09h | UTC
WHO Guidance | Walking and cycling: latest evidence to support policy-making and practice.
13 Jun, 2022 | 08:06h | UTC
Commentary on Twitter
Evidence shows that investments in promoting safe cycling and walking can play a key role in shaping health and mitigating climate change and improving the environment, says new WHO report ? https://t.co/KJetzwqojl#ECEH #THEPEP pic.twitter.com/HdS7VEfr32
— WHO/Europe (@WHO_Europe) June 6, 2022
Brief Review: Mental health morbidity, self-harm, and suicide in ICU survivors and caregivers.
13 Jun, 2022 | 08:01h | UTCMental health morbidity, self-harm, and suicide in ICU survivors and caregivers – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
#ICU mental health outcomes? The more we discover, the more we realize we need to care for a vulnerable population!
? mental health morbidity among survivors
? mental health morbidity among caregivers
? risk prediction/mitigation
? future directions
? https://t.co/wo8QdP8Mz9 pic.twitter.com/9jX6h9SdRz— Intensive Care Medicine (@yourICM) June 7, 2022
Brief Review: How to manage anticoagulation during extracorporeal membrane oxygenation.
13 Jun, 2022 | 08:03h | UTCHow to manage anticoagulation during extracorporeal membrane oxygenation – Intensive Care Medicine (if the link is paywalled, try this one)
Related: 2021 ELSO Adult and Pediatric Anticoagulation Guidelines – ASAIO Journal
Canada to require a warning be printed on every cigarette.
13 Jun, 2022 | 07:58h | UTCCanada to require a warning be printed on every cigarette – Associated Press
Subgroup analyses in randomized clinical trials: value and limitations.
13 Jun, 2022 | 07:57h | UTC
RCT: Ustekinumab vs. adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn’s disease.
13 Jun, 2022 | 07:56h | UTCUstekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn’s disease: a multicentre, randomised, double-blind, parallel-group, phase 3b trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
New @TheLancet – Sands et al – Ustekinumab versus adalimumab for induction and maintenance therapy in biologic-naive patients with moderately to severely active Crohn's disease (SEAVUE trial)https://t.co/Ov9ahRTQuC#IBD #GITwitter #Crohnsdisease pic.twitter.com/5f3vI6rRKd
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) June 10, 2022
Expert Analysis: Pericarditis management in pregnancy.
13 Jun, 2022 | 07:49h | UTCPericarditis Management in Pregnancy – American College of Cardiology
Causes of liver cancer are changing around the world: some up, some down.
13 Jun, 2022 | 07:54h | UTCNews Release: Causes of Liver Cancer are Changing Around the World: Some Up, Some Down – UC San Diego Health
Original Study: Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer – Cell Metabolism (link to abstract – $ for full-text)
SGLT2 inhibitor reduces the risk of hyperkalemia in patients with heart failure.
13 Jun, 2022 | 07:52h | UTCEditorial: Emerging role for SGLT2 inhibitors in mitigating the risk of hyperkalaemia in heart failure
Commentary on Twitter
More evidence that SGLT2i ⬇️ hyperK, this time in heart failure
Empagliflozin reduces:
– K>6.0: HR 0.62 95% CI 0.48–0.81
– Investigator reported hyperK or K binders, HR 0.82 95% CI 0.71-0.95
– Effect modified by GFR – larger in CKD
– Regardless of MRAshttps://t.co/t4T7II1G8p pic.twitter.com/RP1EUKXHyV— Brendon Neuen (@brendonneuen) June 12, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Study: Most males who die by suicide have no known mental health condition.
13 Jun, 2022 | 07:48h | UTCCommentary: Most Males Who Die by Suicide Have No Known Mental Health Condition – Psychiatric News Alert
Original study: Suicide Among Males Across the Lifespan: An Analysis of Differences by Known Mental Health Status – American Journal of Preventive Medicine
Cohort Study: Long-term outcomes of early use of long-acting injectable antipsychotics in schizophrenia.
13 Jun, 2022 | 07:46h | UTCLong-term Outcomes of Early Use of Long-Acting Injectable Antipsychotics in Schizophrenia – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Related:
Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link to abstract – $ for full-text)
Long-acting injectable versus oral antipsychotics for the maintenance treatment of schizophrenia: a systematic review and comparative meta-analysis of randomised, cohort, and pre–post studies – The Lancet Psychiatry (link to abstract – $ for full-text)
Host-directed immunotherapy of viral and bacterial infections: past, present and future.
13 Jun, 2022 | 07:41h | UTCHost-directed immunotherapy of viral and bacterial infections: past, present and future – Nature Reviews Immunology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
A Perspective in @NatRevImmunol reflects on the historical development of host-directed immunotherapeutic interventions for infections and how historical insights can be used in the therapy of SARS-CoV-2 and Mycobacterium tuberculosis infections. https://t.co/5WOXzePpFS pic.twitter.com/dpj1XNi2me
— Nature Portfolio (@NaturePortfolio) June 11, 2022
Case reports: thalidomide therapy in 18 patients with severe arteriovenous malformations.
13 Jun, 2022 | 07:39h | UTCCase report study of thalidomide therapy in 18 patients with severe arteriovenous malformations – Nature Cardiovascular Research (link to abstract – $ for full-text)
Systematic Review: Oxycodone for cancer‐related pain.
13 Jun, 2022 | 07:37h | UTCOxycodone for cancer‐related pain – Cochrane Library
Summary: Oxycodone for cancer-related pain in adults – Cochrane Library