Daily Archives: May 16, 2022
RCT: Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs. open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer.
16 May, 2022 | 02:35h | UTCEditorial: Robotic Surgery for Bladder Cancer – JAMA
Commentary on Twitter
In this trial, robot-assisted surgery vs open surgery for radical cystectomy among patients with #bladdercancer resulted in a statistically significantly greater number of days alive and out of the hospital. https://t.co/icPLiKH0Lf
— JAMA (@JAMA_current) May 15, 2022
RCT: Albuterol–budesonide fixed-dose combination rescue inhaler for asthma.
16 May, 2022 | 02:33h | UTCAlbuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
The risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with albuterol alone. #ATS2022 https://t.co/MRGaUaGVwj pic.twitter.com/6BZX9Q6WxX
— NEJM (@NEJM) May 15, 2022
RCT: Effect of awake prone positioning on endotracheal intubation in patients with COVID-19 and acute respiratory failure.
16 May, 2022 | 02:37h | UTCRelated:
RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Commentary on Twitter
In this trial, in patients with acute hypoxemic respiratory failure from #COVID19, prone positioning, compared with usual care without prone positioning, did not significantly reduce endotracheal intubation at 30 days. https://t.co/1RyYRtcrYj
— JAMA (@JAMA_current) May 15, 2022
Trial of a preferential Phosphodiesterase 4B Inhibitor for idiopathic pulmonary fibrosis.
16 May, 2022 | 02:32h | UTCTrial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In a placebo-controlled trial, treatment with the phosphodiesterase 4 inhibitor BI 1015550 prevented a decrease in lung function over a 12-week period in patients with idiopathic pulmonary fibrosis. #ATS2022 https://t.co/G60NO2ntRR pic.twitter.com/pUNqnBhhPB
— NEJM (@NEJM) May 15, 2022
RCT: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults.
16 May, 2022 | 02:30h | UTCComparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial – Intensive Care Medicine (free article here)
Commentary on Twitter
? 8 vs 15 days ABT for Pseudomonas aeruginosa VAP in adults, iDIAPASON RCT: no differences in composite or separate outcomes (90-day mortality/VAP recurrence) between short & long duration treatment.
? @yourICM ground-breaking release #LIVES40 #FOAMcc
? https://t.co/LfoUWxCkkl pic.twitter.com/XaWkQ5R6wT— Intensive Care Medicine (@yourICM) May 13, 2022
Test-negative, case-control study: Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during Omicron predominance.
16 May, 2022 | 02:25h | UTCEditorial: Protecting Children Against Omicron – JAMA
Commentary on Twitter (thread – click for more)
This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see?)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022
ESC Position Paper: Integrated care for optimizing the management of stroke and associated heart disease.
16 May, 2022 | 02:29h | UTC
Commentary on Twitter
Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Strokehttps://t.co/L7dPxM6dZx#EHJ #stroke @escardio @ESC_Journals #CardioTwitter pic.twitter.com/MB6mIqzdui
— EHJ Editor-in-Chief (@ehj_ed) May 14, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Clinical Report: Health supervision for children and adolescents with Down Syndrome.
16 May, 2022 | 02:15h | UTCHealth Supervision for Children and Adolescents With Down Syndrome – Pediatrics
European Guidelines on the management of female non-neurogenic lower urinary tract symptoms.
16 May, 2022 | 02:13h | UTC
International evidence-based recommendations for point-of-care lung ultrasound.
16 May, 2022 | 02:20h | UTCInternational evidence-based recommendations for point-of-care lung ultrasound – Intensive Care Medicine (if the link is paywalled, try this one)
2022 EULAR points to consider for remote care in rheumatic and musculoskeletal diseases.
16 May, 2022 | 02:11h | UTC
Commentary on Twitter
2022 #EULAR points to consider for remote care in #rheumatic and #musculoskeletal diseaseshttps://t.co/oB0Fo0wzoM pic.twitter.com/LS95rSvCmh
— ARD & RMD Open (@ARD_BMJ) April 27, 2022
EAP Recommendations: Adolescents with eating disorders in pediatric practice.
16 May, 2022 | 02:12h | UTC
Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors.
16 May, 2022 | 01:55h | UTC
RCT: Efficacy and safety of ultrahigh-dose Methylcobalamin in early-stage amyotrophic lateral sclerosis.
16 May, 2022 | 02:02h | UTCEfficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)
Commentary on Twitter
A phase 3 clinical trial found ultra-high dose methylcobalamin slowed functional decline in patients with early-stage amyotrophic lateral sclerosis. https://t.co/r5KP38JkUc
— JAMA Neurology (@JAMANeuro) May 9, 2022
RCT: Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes.
16 May, 2022 | 01:51h | UTCCommentary: DAWN: Support for dorzagliatin–metformin combination therapy in type 2 diabetes – medwireNews
Commentary on Twitter
The DAWN study is a #phase3 clinical trial that demonstrates effective #glycemic control of #dorzagliatin as an add-on therapy to #metfomin in patients with type 2 #diabetes. #T2D #NMEDClinicalhttps://t.co/9bHWQNvNTJ
— Nature Medicine (@NatureMedicine) May 12, 2022
[News release – not published yet] Gallstone disease shown to be a strong predictor of pancreatic cancer.
16 May, 2022 | 01:49h | UTC
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
16 May, 2022 | 01:45h | UTC
Commentary on Twitter
SR: there is moderate evidence of the efficacy of gabapentinoids in anxiety states (SMD ranging between -2.25 and -0.25), but minimal evidence in bipolar disorder and insomnia and they should be used for these disorders only with strong justification https://t.co/zrxduX2q6l pic.twitter.com/6mKYwHKKbo
— PfOL (@psychopharmacol) May 12, 2022
Under a http://creativecommons.org/licenses/by/4.0/ license
RCT: Fixed-duration Ibrutinib-Venetoclax in patients with chronic lymphocytic leukemia and comorbidities.
16 May, 2022 | 01:47h | UTC
Commentary on Twitter
In older patients and/or those with comorbidities with untreated #CLL, treatment with ibrutinib-venetoclax was superior to chlorambucil-obinutuzumab, with fewer events and longer PFS after just over 2 yrs of follow-up. Read about the GLOW trial: https://t.co/gYjksIhp96
#LeuSM pic.twitter.com/aBnpdeKhFO— NEJM Evidence (@NEJMEvidence) May 13, 2022
Molecular diagnostics in severe pneumonia: a new dawn or false promise?
16 May, 2022 | 01:43h | UTCMolecular diagnostics in severe pneumonia: a new dawn or false promise? – Intensive Care Medicine
Commentary on Twitter
Pneumonia? no gold standard diagnosis available, likely resulting in overtreatment. Molecular diagnostics more widely available even if interpretation/use complex, requiring to take into account data/characteristics when making decisions based on these.
? https://t.co/mae0vxBfkF pic.twitter.com/bbkxGLEumN— Intensive Care Medicine (@yourICM) May 14, 2022
Risk-adapted modulation through de-intensification of cancer treatments: an ESMO classification.
16 May, 2022 | 01:39h | UTC
Commentary on Twitter
Beautiful paper by @darioT_ on Risk-adapted modulation through de-intensification of cancer treatments: an ESMO classification @myESMO https://t.co/795AZdLP4K
— Hal Burstein, MD (@DrHBurstein) May 10, 2022
Under a CC BY-NC-ND 4.0 license
Effectiveness of pre-anesthetic assessment clinic: a systematic review of randomized and non-randomized prospective controlled studies.
16 May, 2022 | 01:42h | UTC
Oral pre-exposure prophylaxis (PrEP) to prevent HIV: a systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populations.
16 May, 2022 | 01:41h | UTC
Systematic Review: Ultrasound for pediatric peripheral intravenous catheter insertion.
16 May, 2022 | 01:28h | UTCUltrasound for Pediatric Peripheral Intravenous Catheter Insertion: A Systematic Review – Pediatrics
RCT: Efficacy and safety of fenfluramine for the treatment of seizures associated With Lennox-Gastaut Syndrome.
16 May, 2022 | 01:29h | UTCCommentaries:
Fenfluramine Found Effective for Treatment of Lennox-Gastaut Syndrome Seizures – NeurologyToday
Fenfluramine Seems Effective for Lennox-Gastaut Syndrome – HealthDay
Commentary on Twitter
In this randomized clinical trial, fenfluramine was a safe and effective treatment option for patients with Lennox-Gastaut syndrome. https://t.co/Ukopx9cV9r @Zogenix pic.twitter.com/dRetoOZSiB
— JAMA Neurology (@JAMANeuro) May 2, 2022