Daily Archives: May 9, 2022 | LinksMedicus Free Medical News & Perspectives

WHO launches first ever global report on infection prevention and control.

9 May, 2022 | 02:19h | UTC

News Release: WHO launches first ever global report on infection prevention and control – World Health Organization

Executive Summary: Global report on infection prevention and control – World Health Organization

Commentary on Twitter

A new report from the World Health Organization (WHO) shows that good Infection Prevention and Control (IPC) programmes where good hand hygiene and other cost-effective practices are followed, 70% of those infections can be prevented #IDTwitter #MedEd https://t.co/qo954eXMm8

— Antibiotic Steward Bassam Ghanem?? (@ABsteward) May 6, 2022

Technical briefing 2: Investigation into acute hepatitis of unknown etiology in children in England.

9 May, 2022 | 02:18h | UTC

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

Summary on Twitter (thread – click for more)

NEW: @UKHSA Technical Briefing 2 on Paediatric acute hepatitis in England

A ? ⤵️https://t.co/E9MvVTK505 pic.twitter.com/YZCHdCdt4U

— ?? Meaghan Kall (@kallmemeg) May 6, 2022

WHO Report: 14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021.

9 May, 2022 | 02:14h | UTC

News Release: 14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021 – World Health Organization

Original Report: Global excess deaths associated with COVID-19, January 2020 – December 2021 – World Health Organization

Commentaries:

Covid-19: True global death toll from pandemic is almost 15 million, says WHO – The BMJ

WHO: Nearly 15 million died as a result of Covid-19 in first two years of pandemic – STAT

WHO notes 15 million excess deaths over 2 COVID years – CIDRAP

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 – The Lancet

“Excess deaths” is the best metric for tracking the pandemic – The BMJ

The pandemic’s true death toll: millions more than official counts – Nature

Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries – The BMJ

Under-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ

Quantifying impacts of the COVID-19 pandemic through life-expectancy losses: a population-level study of 29 countries – International Journal of Epidemiology

Just How Do Deaths Due to COVID-19 Stack Up? – Think Global Health

Commentary on Twitter (thread – click for more)

The total number of deaths associated with #COVID19 worldwide from 2020-2021 may be closer to 14.9 million: New estimates by WHO & @UNDESA.

That’s 9.5 million more deaths than reported https://t.co/qDvaA6t5KZ #HealthData pic.twitter.com/ZjABJzlgiZ

— World Health Organization (WHO) (@WHO) May 5, 2022

Studies show promise for 2 new COVID vaccine platforms.

9 May, 2022 | 02:12h | UTC

Commentary: Studies show promise for 2 new COVID vaccine platforms – CIDRAP

Study 1: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine – New England Journal of Medicine

Study 2: Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults – New England Journal of Medicine

Editorial: Does the World Still Need New Covid-19 Vaccines?

Commentaries on Twitter

Efficacy of a plant-based vaccine with adjuvant was 69.5% against symptomatic #COVID19 and 78.8% against moderate-to-severe disease. https://t.co/WH54QWCBdg pic.twitter.com/BiEYpJUD7D

— NEJM (@NEJM) May 4, 2022

ZF2001 vaccine has 87% efficacy against critical or severe #COVID19 for at least 6 months after full vaccination and was safe in large cohort of adults. #IDTwitter https://t.co/wsG0AXqI4Y pic.twitter.com/45fqwVrz9a

— NEJM (@NEJM) May 4, 2022

Systematic Review: Workplace interventions to reduce the risk of SARS‐CoV‐2 infection outside of healthcare settings.

9 May, 2022 | 02:09h | UTC

Workplace interventions to reduce the risk of SARS‐CoV‐2 infection outside of healthcare settings – Cochrane Library

Summary: Interventions to reduce the risk of coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infection among workers outside healthcare settings – Cochrane Library

Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials.

9 May, 2022 | 01:52h | UTC

Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials – European Heart Journal

Commentary on Twitter

Timing of invasive management of NSTE-ACS: is the time up for early management?

Timing of invasive strategy in #NSTEMI : a meta-analysis of randomized controlled trialshttps://t.co/XD074Lh94S @ESC_Journals @escardio @mmamas1973 @ALEX_MISCHIE @AnkurKalraMD @HeartOTXHeartMD pic.twitter.com/0XekZqvJop

— Henry Han, MBBS, MD (@HanCardiomd) May 6, 2022

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

Brief Review | In search of the Holy Grail: identifying the best PEEP in ventilated patients.

9 May, 2022 | 01:50h | UTC

In search of the Holy Grail: identifying the best PEEP in ventilated patients – Intensive Care Medicine

Commentary on Twitter

Best PEEP on MV?? Individual-specific providing oxygenation (SpO2 >90%/no excessive FiO2 + acceptable PaCO2 (<50/55 mmHg) & minimal need for fluids/cardioactives. Start at 10-12 but stay alert to hemodynamic impact & as set, serially asses need/adequacy.
?https://t.co/wdK92bs8B9 pic.twitter.com/NlTzoxfwa5

— Intensive Care Medicine (@yourICM) May 5, 2022

Brief Review | Oxygen targets.

9 May, 2022 | 01:48h | UTC

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Commentary on Twitter

Oxygen targets in #ICU?? Supplemental O2 often required in critically ill, but balancing opposing risks hypo/hyperxaemia required to choose right amount to give. Hyperoxaemia associated with negative cellular/physiological effects: O2 can harm!#FOAMcc
? https://t.co/F4r3Qg7hXg pic.twitter.com/EizwMNjjnc

— Intensive Care Medicine (@yourICM) May 7, 2022

Systematic Review: Comprehensive Geriatric Assessment for community‐dwelling, high‐risk, frail, older people.

9 May, 2022 | 01:43h | UTC

Comprehensive Geriatric Assessment for community‐dwelling, high‐risk, frail, older people – Cochrane Library

Summary: Comprehensive Geriatric Assessment for older people in the community at risk of poor health outcomes – Cochrane Library

Systematic Review: Outpatient versus inpatient treatment for acute pulmonary embolism.

9 May, 2022 | 01:47h | UTC

Outpatient versus inpatient treatment for acute pulmonary embolism – Cochrane Library

Commentary: Is home or hospital treatment better for people with blood clots in the lungs? – Cochrane Library

Commentary on Twitter

#CochraneEvidence updated – Is home or hospital treatment better for people with blood clots in the lungs? #VTE #PE #CLOT https://t.co/6tubeADzUY @CochraneLibrary @CochraneUK @NIHRresearch @VSGBI @PERTConsortium @isth @APPTGThrombosis @accpchest @EuropeanTHA @ThrombosisCan pic.twitter.com/JDTio2KC1N

— CochraneVasc (@CochraneVasc) May 6, 2022

Systematic Review: Negative pressure wound therapy for managing the open abdomen in non‐trauma patients.

9 May, 2022 | 01:41h | UTC

Negative pressure wound therapy for managing the open abdomen in non‐trauma patients – Cochrane Library

Commentary: What are the benefits and risks of negative pressure wound therapy for managing the open abdomen in people who are not trauma patients? – Cochrane Library

Retrospective Cohort Study: Identification of patients with branch-duct intraductal papillary mucinous neoplasm and very low risk of cancer.

9 May, 2022 | 01:40h | UTC

Identification of patients with branch-duct intraductal papillary mucinous neoplasm and very low risk of cancer: multicentre study – British Journal of Cancer

Commentary on Twitter

BD-IPMN ? at very low risk of cancer ? how to identify patients for surveillance

? Multicentre Pancreas 2000 study of @EurPancClub

⚠️ 20% develop WF/HRS at FU
? 80% with WF/HRS still surveilled safely

? MOST BD IPMN will never need surgery ?https://t.co/YPHaQd98u1 pic.twitter.com/ypglRlNR2q

— Giovanni Marchegiani (@Gio_Marchegiani) May 7, 2022

Clinical challenges treating Stenotrophomonas maltophilia infections: an update.

9 May, 2022 | 01:32h | UTC

Clinical challenges treating Stenotrophomonas maltophilia infections: an update – JAC-Antimicrobial Resistance

Overcoming Stenotrophomonas maltophilia Resistance for a More Rational Therapeutic Approach – Open Forum Infectious Diseases

Risk Factors for Acquired Stenotrophomonas maltophilia Pneumonia in Intensive Care Unit: A Systematic Review and Meta-Analysis – Frontiers in Medicine

Trimethoprim-Sulfamethoxazole versus Levofloxacin for Stenotrophomonas maltophilia Infections: A Retrospective Comparative Effectiveness Study of Electronic Health Records from 154 U.S. Hospitals – Open Forum Infectious Diseases

Infectious Diseases Society of America Guidance on the Treatment of AmpC β-lactamase-Producing Enterobacterales, Carbapenem-Resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia Infections – Clinical Infectious Diseases

Phase 2 RCT: Anti-tumor necrosis factor therapy for early-stage Dupuytren’s disease.

9 May, 2022 | 01:38h | UTC

Anti-tumour necrosis factor therapy for early-stage Dupuytren’s disease (RIDD): a phase 2b, randomised, double-blind, placebo-controlled trial – The Lancet Rheumatology

News Release: Breakthrough in treatment for Dupuytren’s disease – University of Oxford

Commentary: Treatment for finger-bending disease may be ‘gamechanger’ – The Guardian

Commentary on Twitter

NEW RESEARCH—Intranodular injections of anti-tumour necrosis factor therapy (adalimumab) for early-stage Dupuytren's disease: a phase 2b, randomised, double-blind, placebo-controlled trial https://t.co/Jz9QUJEzS8 #LancetRheumatology #OpenAccess pic.twitter.com/mcZj9GK4l4

— The Lancet Rheumatology (@TheLancetRheum) May 4, 2022

RCT: Reloxaliase vs. placebo in enteric hyperoxaluria.

9 May, 2022 | 01:30h | UTC

Randomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria – NEJM Evidence

Commentary on Twitter

Patients with enteric hyperoxaluria received reloxaliase, an enzyme that degrades oxalate in the GI tract, or placebo with food for 4 weeks. There was a greater reduction in urinary oxalate excretion with reloxaliase. https://t.co/x7m12QHyWX #NephTwitter #UroSoMe #ClinicalTrials pic.twitter.com/rzCpd6YfLM

— NEJM Evidence (@NEJMEvidence) May 6, 2022

RCT: Terminal complement inhibitor Ravulizumab in generalized myasthenia gravis.

9 May, 2022 | 01:27h | UTC

Terminal Complement Inhibitor Ravulizumab in Generalized Myasthenia Gravis – NEJM Evidence

Commentary on Twitter

In this RCT, Ravulizumab provided rapid and efficacious treatment of adult patients with anti-AChR antibody-positive generalized myasthenia gravis (gMG), as determined by both patient- and clinician-rated outcomes, with few adverse events. https://t.co/9mlCOULiJR #NeuroTwitter pic.twitter.com/ZljrTs282f

— NEJM Evidence (@NEJMEvidence) May 3, 2022

Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids.

9 May, 2022 | 01:23h | UTC

Commentary: Diagnostic stewardship tied to fewer blood cultures, antibiotics in sick kids – CIDRAP

Original Study: Association of Diagnostic Stewardship for Blood Cultures in Critically Ill Children With Culture Rates, Antibiotic Use, and Patient Outcomes: Results of the Bright STAR Collaborative – JAMA Peditrics

News Release: Hospitals can reduce antibiotic overuse by avoiding unnecessary blood draws in critically ill children, study shows – Johns Hopkins University School of Medicine

Commentary on Twitter

Results from the Bright STAR collaborative: Multi-center diagnostic stewardship found blood cultures in the PICU safely reduced overtesting and broad-spectrum antibiotic use. https://t.co/523QlbOLL2 @BrightSTAR_QI @HopkinsKids @ChildrensPhila #PICUtwitter

— JAMA Pediatrics (@JAMAPediatrics) May 2, 2022

Derivation and validation of a score for predicting poor neurocognitive outcomes in acute carbon monoxide poisoning.

9 May, 2022 | 01:20h | UTC

Derivation and Validation of a Score for Predicting Poor Neurocognitive Outcomes in Acute Carbon Monoxide Poisoning – JAMA Network Open

RCT: Efficacy and safety of Difelikefalin in patients with moderate to severe pruritus receiving hemodialysis.

9 May, 2022 | 01:21h | UTC

Efficacy and Safety of Difelikefalin in Japanese Patients With Moderate to Severe Pruritus Receiving Hemodialysis: A Randomized Clinical Trial – JAMA Network Open

Commentary on Twitter

This RCT found difelikefalin, a κ-opioid receptor agonist, improved moderate to severe pruritus in Japanese hemodialysis patients. Difelikefalin is expected to be a new option for the treatment of uremic pruritus in patients with end stage kidney disease. https://t.co/cXqNx4QIaS pic.twitter.com/7QdA9GoLwN

— JAMA Network Open (@JAMANetworkOpen) May 5, 2022

Cohort Study: Anal incontinence after a prolonged second stage of labor in primiparous women.

9 May, 2022 | 01:25h | UTC

Anal incontinence after a prolonged second stage of labor in primiparous women – Scientific Reports

Cohort Study: Rotating night shift work and healthy aging after 24 years of follow-up in the Nurses’ Health Study.

9 May, 2022 | 02:29h | UTC

Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses’ Health Study – JAMA Network Open

Commentary: Rotating Night Shifts May Hamper Healthy Aging – HealthDay

Commentary on Twitter

This cohort study of 24 years of follow-up from Nurses' Health Study found that long periods of rotating night shift work were associated with modestly decreased odds of healthy aging in women. https://t.co/HY3p136gkC

— JAMA Network Open (@JAMANetworkOpen) May 4, 2022

Artificial intelligence for screening of multiple retinal and optic nerve diseases.

9 May, 2022 | 01:18h | UTC

Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases – JAMA Network Open

Commentary on Twitter

This diagnostic study developed and prospectively validated a #DeepLearning algorithm to recognize multiple retinal diseases, with better accuracy vs retinal specialists, and may help to overcome the lack of ophthalmologists in underdeveloped areas. https://t.co/9fvwOTVV8N

— JAMA Network Open (@JAMANetworkOpen) May 3, 2022