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Daily Archives: April 22, 2022

WHO recommends highly successful COVID-19 therapy (nirmatrelvir-ritonavir) and calls for wide geographical distribution and transparency from originator.

22 Apr, 2022 | 09:36h | UTC

WHO recommends highly successful COVID-19 therapy and calls for wide geographical distribution and transparency from originator – World Health Organization

See also:

A living WHO guideline on drugs for covid-19 – The BMJ

Therapeutics and COVID-19: living guideline – World Health Organization

Related:

Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19 – New England Journal of Medicine

Prescribing Nirmatrelvir–Ritonavir: How to Recognize and Manage Drug–Drug Interactions – Annals of Internal Medicine

The COVID-19 Treatment Guidelines Panel’s Statement on Potential Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications – NIH COVID-19 Treatment Guidelines Panel

 

Commentary on Twitter

 

CDC alerts providers to hepatitis cases of unknown origin.

22 Apr, 2022 | 09:34h | UTC

News Release: CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

See Guidance: Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Commentaries:

CDC issues health advisory about acute hepatitis in children – CNN

CDC Issues Alert for Hepatitis in Children With Adenovirus Infection – WebMD

Related:

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries.

22 Apr, 2022 | 09:28h | UTC

Policy stringency and mental health during the COVID-19 pandemic: a longitudinal analysis of data from 15 countries – The Lancet Public Health

News Release: Stricter COVID-19 measures associated with negative mental health effects and lower opinion of government’s pandemic response, new research suggests – The Lancet

Commentary: Stricter Pandemic Policies Took Toll on Mental Health — Women tended to be more affected than men – MedPage Today

 

UK drug regulator advises patients and doctors against the use of Pregabalin during pregnancy due to a possible increased risk of congenital malformations.

22 Apr, 2022 | 09:31h | UTC

Pregabalin (Lyrica): findings of safety study on risks during pregnancy – Medicines and Healthcare products Regulatory Agency

See also: Pregabalin and risks in pregnancy – Medicines and Healthcare products Regulatory Agency

Source: Avoid prescribing pregabalin during pregnancy if possible, says UK drug regulator – The BMJ ($)

 

Commentary on Twitter

 

One-year follow-up of a RCT: In ICU patients with severe hypoxemia, there was no difference in long-term mortality and health-related quality of life with lower vs. higher oxygenation targets.

22 Apr, 2022 | 09:32h | UTC

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Original Study: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

 

Commentary on Twitter

 

M-A: Clinical efficacy of adjuvant treatments for patients with resected biliary tract cancer.

22 Apr, 2022 | 09:26h | UTC

Clinical efficacy of adjuvant treatments for patients with resected biliary tract cancer: a systematic review and network meta-analysis – BMJ Open

 

Cardiovascular risk stratification by coronary computed tomography angiography imaging: current state-of-the-art.

22 Apr, 2022 | 09:22h | UTC

Cardiovascular risk stratification by coronary computed tomography angiography imaging: current state-of-the-art – European Journal of Preventive Cardiology

 

State of the Art Review: Novel treatments in B cell non-Hodgkin’s lymphomas.

22 Apr, 2022 | 09:24h | UTC

Novel treatments in B cell non-Hodgkin’s lymphomas – The BMJ

 

Commentary on Twitter

 

PRISMA 2020 and PRISMA-S: common questions on tracking records and the flow diagram.

22 Apr, 2022 | 09:19h | UTC

PRISMA 2020 and PRISMA-S: common questions on tracking records and the flow diagram – Journal of the Medical Library Association

 

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

22 Apr, 2022 | 09:21h | UTC

Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial – The Lancet HIV

Invited Commentary: Game-changing study of second-line HIV treatment – The Lancet HIV (free registration required)

Original Study: Dolutegravir or Darunavir in Combination with Zidovudine or Tenofovir to Treat HIV – New England Journal of Medicine

 

Commentary on Twitter

 

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