Daily Archives: April 20, 2022
USPSTF Draft Statement: Postmenopausal women should not use hormone therapy to prevent chronic health problems.
20 Apr, 2022 | 10:15h | UTCDraft Recommendation Statement: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons – U.S. Preventive Services Task Force
Commentary: USPSTF Advises Against Hormone Therapy to Prevent Chronic Conditions – HealthDay
Studies highlight meningitis vaccine’s potential against gonorrhea.
20 Apr, 2022 | 10:06h | UTCCommentary: Studies highlight meningitis vaccine’s potential against gonorrhea – CIDRAP
News Release: Threat of untreatable gonorrhoea could be tackled using an existing meningitis vaccine – The Lancet
Study 1: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Study 2: Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
An observational study suggests coprescription of Phosphodiesterase Type 5 Inhibitors (i.e., sildenafil) and oral Nitrates is not associated with increased risk of adverse cardiovascular outcomes in male patients with ischemic heart disease.
20 Apr, 2022 | 10:11h | UTCCommentaries:
PDE5 Inhibitors Prescribed for Men on Oral Nitrates for IHD – HealthDay
Big Tech in Healthcare: Here’s who wins and loses as Alphabet, Amazon, Apple, and Microsoft target niche sectors of healthcare.
20 Apr, 2022 | 09:59h | UTC
Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel.
20 Apr, 2022 | 09:57h | UTCCovid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel – STAT
Expert Guidance: Strategies to prevent central line-associated bloodstream infections in acute-care hospitals.
20 Apr, 2022 | 10:13h | UTC
Commentary on Twitter
Prevention of central line-associated bloodstream infections in acute-care hospitals- 2022 updatehttps://t.co/o3AReYvJIu pic.twitter.com/QsgYYezhqj
— K Pavithran (@drkpavithran) April 19, 2022
Article under a http://creativecommons.org/licenses/by/4.0/ license
FDA warns of risks associated with non-invasive prenatal screening tests – inappropriate interpretation of results may lead to potentially improper medical decisions.
20 Apr, 2022 | 09:52h | UTC
A nonrandomized controlled study found awake prone position (median of 4.2 hours per day) may not benefit hospitalized adults with Covid-19.
20 Apr, 2022 | 09:56h | UTCCommentaries:
Study suggests worse outcomes for awake COVID patients in prone position – CIDRAP
Putting Hospitalized COVID Patients on Their Belly May Not Be a Good Idea After All – HealthDay
Related:
RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Commentary on Twitter (thread – click for more)
Important negative study: non randomized trial finds no clinical benefit to awake proning vs usual care in COVID
No difference in rates of intubation, length of stay, or 28 day mortality
Medicine is humbling. This emphasizes the importance of trials
?https://t.co/ksh9Ic9XBL
1/ pic.twitter.com/sjHHv4WQs8— Nick Mark MD (@nickmmark) April 18, 2022
German guidelines for the diagnosis and treatment of varicose veins.
20 Apr, 2022 | 09:49h | UTCS2k guidelines: diagnosis and treatment of varicose veins – Leitlinien und Empfehlungen
RCT: Substrate ablation vs. antiarrhythmic drug therapy for symptomatic ventricular tachycardia.
20 Apr, 2022 | 09:46h | UTCSubstrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Podcast: Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia
Review | Blood pressure and its variability: classic and novel measurement techniques.
20 Apr, 2022 | 09:42h | UTCBlood pressure and its variability: classic and novel measurement techniques – Nature Reviews Cardiology (if the link is paywalled, try this one)
ASCO Guideline Update: biomarkers for adjuvant endocrine and chemotherapy in early-stage breast cancer.
20 Apr, 2022 | 09:47h | UTC
Cohort Study: Infertility in women linked to increased risk of heart failure with preserved ejection fraction.
20 Apr, 2022 | 09:44h | UTCInfertility and Risk of Heart Failure in the Women’s Health Initiative – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Podcast: Infertility and Risk of Heart Failure in the Women’s Health Initiative
Commentaries:
Infertility in Women Linked to Subsequent Risk of HFpEF – TCTMD
MGH study finds infertility associated with increased risk of heart failure – MedicalResearch
Evaluation of the causes of sex disparity in heart failure trials.
20 Apr, 2022 | 09:41h | UTCEvaluation of the causes of sex disparity in heart failure trials – Heart
Commentary on Twitter
⚠️Evaluation of the causes of sex disparity in #HF trials
?146 HF trials, which 248620 ?
??♀️ was 25.8%
? ⬆️% of?♀️ in trials assessing HFpEF(51.6%)
? https://t.co/eFo35GdDPG @Heart_BMJ @secardiologia @IcyfaSemi pic.twitter.com/WaCtANqaIk— Alfonso Valle (@ValleAlfonso) April 19, 2022
Images and article under a http://creativecommons.org/licenses/by-nc/4.0/ license
M-A: Association of immune checkpoint inhibitors with neurologic adverse events.
20 Apr, 2022 | 09:34h | UTCInvited Commentary: Neurological Toxic Effects Associated With Treatment With Immune Checkpoint Inhibitors—Are We Really Safer Now? – JAMA Network Open
Related:
Autoimmune Encephalitis Related to Cancer Treatment With Immune Checkpoint Inhibitors: Systematic Review – Neurology (link to abstract – $ for full-text)
Commentary on Twitter
Meta-analysis of 39 RCTs found immune checkpoint inhibitors have lower risk of neurological adverse effects compared to cytotoxic chemotherapy, but higher than placebo, across a range of malignancies. https://t.co/02GhICcu5H
— JAMA Network Open (@JAMANetworkOpen) April 19, 2022
Systematic Review: Treatment of periodontitis for glycemic control in people with diabetes mellitus.
20 Apr, 2022 | 09:36h | UTCTreatment of periodontitis for glycaemic control in people with diabetes mellitus – Cochrane Library
Commentary on Twitter
Does treatment for gum disease help people with diabetes control their blood sugar levels? Evidence from @CochraneLibrary: https://t.co/lk6nGrAIpp pic.twitter.com/UZXKr5b4Rs
— Cochrane Oral Health (@CochraneOHG) April 19, 2022
Cohort Study: Rates and causes of mortality among children and young people with and without intellectual disabilities in Scotland.
20 Apr, 2022 | 09:22h | UTC
Commentary on Twitter
Very sobering study based on Scottish data. Children and young people with intellectual disability are at far higher risk of death and are more likely to have an avoidable death – one amenable to timely, effective care. https://t.co/xuxYjVrRd8
— Mary Dixon-Woods (@MaryDixonWoods) April 16, 2022
National, regional, and global estimates of anemia by severity in women and children for 2000–19.
20 Apr, 2022 | 09:25h | UTCInvited Commentary: Sustainable Development Goals for anaemia: 20 years later, where are we now? – The Lancet Global Health
RCT: Sintilimab vs. placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic esophageal squamous cell carcinoma.
20 Apr, 2022 | 09:28h | UTC
Commentary on Twitter
Compared with placebo, sintilimab in combination with chemo showed significant benefits in overall survival and progression free survival as first line treatment in patients with advanced or metastatic oesophageal squamous cell carcinoma, finds study https://t.co/m8Gn3SBmCu
— The BMJ (@bmj_latest) April 19, 2022
Cohort Study: Association of maternal autoimmune diseases with risk of mental disorders in offspring in Denmark.
20 Apr, 2022 | 09:19h | UTC
Commentary on Twitter
https://twitter.com/JAMANetworkOpen/status/1515057370715594753
Development and validation of machine learning models for predicting occult nodal metastasis in early-stage oral cavity squamous cell carcinoma.
20 Apr, 2022 | 09:14h | UTC
Commentary on Twitter
In this diagnostic modeling study, #MachineLearning models built with multi-institutional data showed potential to reduce morbidity from elective neck dissections with similar cancer outcomes in patients with early-stage oral cavity squamous cell carcinoma https://t.co/aRktgc0ms6
— JAMA Network Open (@JAMANetworkOpen) April 13, 2022
Cohort Study: Association of subjective memory complaints with white matter hyperintensities and cognitive decline among older adults.
20 Apr, 2022 | 09:17h | UTCCommentary: Memory complaints associated with structural brain abnormalities and increased dementia risk – HealthImaging
Commentary on Twitter
In this cohort study, subjective memory complaints (SMCs) were associated with larger white matter hyperintensity volumes and faster cognitive decline, suggesting that SMCs are an important sign of cognitive impairment. https://t.co/mpCXDbylnf
— JAMA Network Open (@JAMANetworkOpen) April 15, 2022
Systematic Review: Evidence-based treatment choices for acute lateral ankle sprain.
20 Apr, 2022 | 09:07h | UTC
RCT: Fuzuloparib maintenance therapy in patients with platinum-sensitive, recurrent ovarian carcinoma.
20 Apr, 2022 | 09:09h | UTCFuzuloparib Maintenance Therapy in Patients With Platinum-Sensitive, Recurrent Ovarian Carcinoma (FZOCUS-2): A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
M-A: Invasive group A streptococcal disease in pregnant women and young children.
20 Apr, 2022 | 09:05h | UTCInvited Commentary: Recognising group A streptococcal disease in pregnancy – The Lancet Infectious Diseases (free registration required)