Daily Archives: April 14, 2022 | LinksMedicus Free Medical News & Perspectives

A nationwide observational analysis in Israel showed a fourth dose of the Pfizer vaccine may reduce the short-term risk of Covid-19–related outcomes.

14 Apr, 2022 | 08:51h | UTC

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting – New England Journal of Medicine

Editorial: Covid-19 Boosters — Where from Here?

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines.

Observational study suggests a fourth dose of the Pfizer vaccine provided additional protection against severe disease in patients 60 years of age or older during the Omicron wave in Israel.

Perspective: The evidence on 4th doses of covid vaccines & the thorny question of age thresholds.

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

Among health care workers, a fourth dose vaccine effectiveness against any SARS-CoV-2 Omicron variant infection was 30% for the Pfizer–BioNTech and 11% for the Moderna.

[Preprint] Fourth dose of COVID vaccine offers only slight boost against Omicron infection.

Covid-19: Fourth vaccine doses—who needs them and why?

[Not published yet] Study in Israel finds fourth COVID booster has limited efficacy.

Commentary on Twitter

In Israel, a fourth dose of BNT162b2 vaccine effective in reducing the short-term risk of Covid-19–related outcomes among those who had received a third dose at least 4 mos earlier. https://t.co/WtHiR9WbLW pic.twitter.com/yzWRLlgHUi

— NEJM (@NEJM) April 13, 2022

Covid-19: What is the evidence for the antiviral molnupiravir?

14 Apr, 2022 | 08:47h | UTC

Covid-19: What is the evidence for the antiviral molnupiravir? – The BMJ

Study showed low rates of severe COVID-19 in children hospitalized with confirmed SARS-CoV-2 infection.

14 Apr, 2022 | 08:49h | UTC

Very low rates of severe COVID-19 in children hospitalised with confirmed SARS-CoV-2 infection in London, England – Journal of Infection

Commentary: Severe COVID-19 extremely rare among children – News Medical

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.

COVID-19 disease severity in children infected with the Omicron variant.

Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year.

Study identifies risk factors for severe CoviD-19 in children.

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

International study identifies predictors of severe outcomes in children with COVID-19.

The Lancet Series: Origins of chronic obstructive pulmonary disease.

14 Apr, 2022 | 08:38h | UTC

Homepage: Origins of chronic obstructive pulmonary disease – The Lancet Respiratory Medicine (free registration required for all articles)

Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder

Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

GETting to know the many causes and faces of COPD

COPD, smoking, and social justice

Commentary on Twitter (thread – click for more)

NEW Series—Origins of #COPD 1) Genetics of #COPD: understanding the pathobiology and heterogeneity of a complex disorder

From @mikecho95, @BrianDHobbs & Prof Edwin Silverman https://t.co/r2tGawHL8r pic.twitter.com/IfQhqJrDaR

— The Lancet Respiratory Medicine (@LancetRespirMed) April 13, 2022

RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.

14 Apr, 2022 | 08:43h | UTC

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Expert Analysis: The role of the posterior left pericardiotomy in reducing pericardial effusion and postoperative atrial fibrillation after cardiac surgery.

14 Apr, 2022 | 08:45h | UTC

The Role of the Posterior Left Pericardiotomy in Reducing Pericardial Effusion and Postoperative Atrial Fibrillation After Cardiac Surgery – American College of Cardiology

Commentary on Twitter

A significantly higher incidence of postoperative #AFib has been found in patients developing pericardial effusion following #cvSurg. Read the expert analysis to learn more: https://t.co/2Pm1wo7Tg0 @AntoninoDiFran1 #cvHCM #CardioTwitter pic.twitter.com/68adiFnFrt

— American College of Cardiology (@ACCinTouch) April 12, 2022

Opinion | The big idea: should we get rid of the scientific paper? – “As a format it’s slow, encourages hype, and is difficult to correct. A radical overhaul of publishing could make science better”.

14 Apr, 2022 | 08:37h | UTC

The big idea: should we get rid of the scientific paper? – The Guardian

M-A: Association between physical activity and risk of depression.

14 Apr, 2022 | 08:35h | UTC

Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis – JAMA Psychiatry

Commentary: Exercise Is Powerful Medicine for Depression – HealthDay

Commentary on Twitter

Meta-analysis found that adults meeting physical activity recommendations had 25% lower risk of #depression compared with adults reporting no #physicalactivity. https://t.co/LITlo954lB

— JAMA Psychiatry (@JAMAPsych) April 13, 2022

Cross-sectional study: The use of Selective Serotonin Reuptake Inhibitors is associated with a reduction in measured movements.

14 Apr, 2022 | 08:32h | UTC

Association of Selective Serotonin Reuptake Inhibitor Use With Abnormal Physical Movement Patterns as Detected Using a Piezoelectric Accelerometer and Deep Learning in a Nationally Representative Sample of Noninstitutionalized Persons in the US – JAMA Network Open

Commentary on Twitter

This cross-sectional study found SSRI use was associated with a reduction in measured movements, highlighting the utility of passively collected data for exploring and characterizing adverse drug effects. https://t.co/54ZngDdt8u

— JAMA Network Open (@JAMANetworkOpen) April 7, 2022

Population based cohort study: Healthy lifestyle and life expectancy with and without Alzheimer’s dementia.

14 Apr, 2022 | 08:27h | UTC

Healthy lifestyle and life expectancy with and without Alzheimer’s dementia: population based cohort study – The BMJ

Editorial: Healthy lifestyles and more life years without dementia – The BMJ

Commentary on Twitter

A new US study suggests that a healthy lifestyle is associated with a longer life expectancy among both men and women, and they lived a larger proportion of their remaining years without Alzheimer’s diseasehttps://t.co/eXsQRd6mon

— The BMJ (@bmj_latest) April 14, 2022

Cohort Study: Non-O blood type is associated with increased risk of venous thromboembolism in patients with cancer.

14 Apr, 2022 | 08:29h | UTC

ABO blood group type and risk of venous thromboembolism in patients with cancer – Blood Advances (link to abstract – $ for full-text)

RCT: Comparison of intranasal vs. intramuscular naloxone in opioid overdoses managed by ambulance staff.

14 Apr, 2022 | 08:23h | UTC

Comparison of intranasal and intramuscular naloxone in opioid overdoses managed by ambulance staff: a double-dummy, randomised, controlled trial – Addiction

Commentary: Breathing restored within 10 minutes for 80% of overdose patients using nasal spray – Norwegian University of Science and Technology

Review: Cutaneous manifestations of monoclonal gammopathy.

14 Apr, 2022 | 08:21h | UTC

Cutaneous manifestations of monoclonal gammopathy – Blood Cancer Journal

M-A: Symptom burden and health-related quality of life in chronic kidney disease.

14 Apr, 2022 | 08:22h | UTC

Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis – PLOS Medicine

M-A: Abdominal vs. perineal approach for external rectal prolapse.

14 Apr, 2022 | 08:11h | UTC

Abdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis – BJS Open

Review: Ethical considerations for Phase I trials in oncology.

14 Apr, 2022 | 08:14h | UTC

Ethical Considerations for Phase I Trials in Oncology – Journal of Clinical Oncology

Commentary on Twitter

? #JCO #CommentsAndControversies: Wondering or wanting to update your knowledge about #ethics & contemporary cancer #phase1 #ClinicalTrials? Check out this review by @RemNil10 @selin_bicer1 @EthicsdoctorP @KimmelmanJ ? https://t.co/yYVq0y3QdU pic.twitter.com/ciQlw1mxcj

— Journal of Clinical Oncology (@JCO_ASCO) April 11, 2022

Systematic review of the incidence of and risk factors for urothelial cancers and renal cell carcinoma among patients with hematuria.

14 Apr, 2022 | 08:16h | UTC

Systematic Review of the Incidence of and Risk Factors for Urothelial Cancers and Renal Cell Carcinoma Among Patients with Haematuria – European Urology (link to abstract – $ for full-text)

Commentary on Twitter

Systematic Review of the Incidence of and Risk Factors for Urothelial Cancers and Renal Cell Carcinoma Among Patients with Haematuriahttps://t.co/zB6CHYKprL @stingrai78 @drimranomar @ahmostafid @soukup_viktor @Phil_Violette pic.twitter.com/Ouv3lFfRpm

— European Urology (@EUplatinum) April 11, 2022

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature.

14 Apr, 2022 | 08:07h | UTC

Discharge preparation and readiness after birth: a scoping review of global policies, guidelines and literature – BMC Pregnancy & Childbirth

WHO recommendations on maternal and newborn care for a positive postnatal experience.

Putting positive experiences at the center of postnatal care.

Economic evaluation: cost-effectiveness of installing barriers at bridge and cliff sites for suicide prevention in Australia.

14 Apr, 2022 | 08:01h | UTC

Cost-effectiveness of Installing Barriers at Bridge and Cliff Sites for Suicide Prevention in Australia – JAMA Network Open

Invited Commentary: Rethinking Suicide Prevention as a Public Health Issue – JAMA Network Open

Commentary on Twitter

This economic evaluation found that barriers installed at multiple bridge sites – but not cliffs – in Australia were a cost-effective measure in reducing suicide rates at bridges. https://t.co/5D0MIzLZ1Y

— JAMA Network Open (@JAMANetworkOpen) April 5, 2022

M-A: Diagnostic validity and clinical utility of genetic testing for hypertrophic cardiomyopathy.

14 Apr, 2022 | 08:09h | UTC

Diagnostic validity and clinical utility of genetic testing for hypertrophic cardiomyopathy: a systematic review and meta-analysis – openheart

Cohort Study: Association of bone mineral density testing with risk of major osteoporotic fractures among older men receiving androgen deprivation therapy to treat localized or regional prostate cancer.

14 Apr, 2022 | 07:59h | UTC

Association of Bone Mineral Density Testing With Risk of Major Osteoporotic Fractures Among Older Men Receiving Androgen Deprivation Therapy to Treat Localized or Regional Prostate Cancer – JAMA Network Open

Editorial: Dual X-ray Absorptiometry Screening for Men Receiving Androgen Deprivation Therapy—Hiding in Plain (Film) Sight – JAMA Network Open

Commentary: Men treated for prostate cancer have increased fracture risk, yet few complete DXA screening – HealthImaging

Commentary on Twitter

In this cohort study, osteoporosis screening rates for over 50,000 elderly men with prostate cancer receiving hormonal therapy nationwide were very low; men who were screened were less likely to suffer major fractures in follow-up. https://t.co/RMz1bvEgiA

— JAMA Network Open (@JAMANetworkOpen) April 1, 2022