Daily Archives: April 1, 2022 | LinksMedicus Free Medical News & Perspectives

Systematic Review: Does giving money to people, in low- and middle-income countries, without conditions attached lead to better health and other life improvements?

1 Apr, 2022 | 10:05h | UTC

Summary: Does giving money to people, in low- and middle-income countries, without conditions attached lead to better health and other life improvements? – Cochrane Library

Original Study: Unconditional cash transfers for reducing poverty and vulnerabilities: effect on use of health services and health outcomes in low‐ and middle‐income countries – Cochrane Library

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults.

1 Apr, 2022 | 10:07h | UTC

Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

Marijuana for medical use may result in rapid onset of cannabis use disorder – Massachusetts General Hospital

Study raises questions about risks of using medical marijuana for mood and anxiety disorders – CNN

Medical Marijuana Rx Ups Odds for Overuse, With No Benefit to Health: Study – HealthDay

Commentary on Twitter

RCT finds medical marijuana cards (MMC) are linked to an increase in cannabis use disorder, with no improvements in pain, depression, and anxiety for adults using medical marijuana but improvements in sleep. https://t.co/0gtGFi1RQ9

— JAMA Network Open (@JAMANetworkOpen) March 18, 2022

State of the Art Review: The heart brain team and patient-centered management of ischemic stroke.

1 Apr, 2022 | 09:53h | UTC

The Heart Brain Team and Patient-Centered Management of Ischemic Stroke – JACC: Advances

RCT: Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones.

1 Apr, 2022 | 10:02h | UTC

Abstract: Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones: the TISU non-inferiority RCT – Health Technology Assessment

Download: Full Report

Study finds no increased risk of brain tumors for mobile phone users.

1 Apr, 2022 | 10:04h | UTC

News Release: No increased risk of brain tumours for mobile phone users, new study finds – University of Oxford

Original Study: Cellular Telephone Use and the Risk of Brain Tumors: Update of the UK Million Women Study – JNCI: Journal of the National Cancer Institute

Cluster RCT: Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation.

1 Apr, 2022 | 10:01h | UTC

Abstract: Co-ordinated multidisciplinary intervention to reduce time to successful extubation for children on mechanical ventilation: the SANDWICH cluster stepped-wedge RCT – Health Technology Assessment

Download: Full Report

Still coughing after COVID? Here’s why it happens and what to do about it.

1 Apr, 2022 | 09:50h | UTC

Still coughing after COVID? Here’s why it happens and what to do about it – The Conversation

Study finds mother-to-child transmission of COVID-19 infection is possible but rare.

1 Apr, 2022 | 09:52h | UTC

News Release: Mother to child transmission of COVID-19 infection, possible but rare, study finds – University of Birmingham

Original Study: SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis – The BMJ

Editorial: Transmission of SARS-CoV-2 from mother to baby is rare

Commentary on Twitter

Mother-to-child transmission of SARS-CoV-2 has been controversial. Our living systematic review & meta-analysis has just been published in BMJ. Transmission has been confirmed, although it is rare, & is more likely when the maternal COVID-19 is severe.https://t.co/Z15kFIk6Zp

— Asma Khalil (@ProfAsmaKhalil) March 19, 2022

Viewpoint: Evaluating the effectiveness of diagnostic tests.

1 Apr, 2022 | 09:47h | UTC

Evaluating the Effectiveness of Diagnostic Tests – JAMA (free for a limited period)

Development of a consensus-based definition of Focused Assessment with Sonography for Trauma (FAST) in children.

1 Apr, 2022 | 08:35h | UTC

Development of a Consensus-Based Definition of Focused Assessment With Sonography for Trauma in Children – JAMA Network Open

Commentaries:

New FAST Definitions May Improve Trauma Assessment of Children – Medscape (free registration required)

Ultrasonographic views, landmarks, and patient-specific factors to consider in a consensus-based definition of the Focused Assessment With Sonography for Trauma in children with abdominal injury – Physician’s Weekly

Commentary on Twitter

Qualitative study describes the development of an expert definition for high-quality & accurate pediatric Focused Assessment with Sonography for Trauma (FAST), including recommended views, landmarks & imaging quality. @aaronkornblith @nkpluso @pocusnetwork https://t.co/4CTvGp2Rqs

— JAMA Network Open (@JAMANetworkOpen) March 18, 2022

Consensus Statement: Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease.

1 Apr, 2022 | 08:51h | UTC

Invasive coronary physiology in patients with angina and non-obstructive coronary artery disease: a consensus document from the coronary microvascular dysfunction workstream of the British Heart Foundation/National Institute for Health Research Partnership – Heart

RCT: Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia.

1 Apr, 2022 | 09:47h | UTC

Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary on Twitter

RCT: At 8 weeks, PANSS total score improved more with amisulpride + olanzapine (−29·6) than with olanzapine + placebo (−24·1, p=0·049, d=0·396), but not vs. amisulpride + placebo (−25·2, p=0·095, d=0·29) in acutely ill patients with schizophrenia https://t.co/Se75PJ3a0N

— P𝘧OL (@psychopharmacol) March 18, 2022

Guideline for the management of neurogenic bowel dysfunction in spinal cord injury/disease.

1 Apr, 2022 | 08:50h | UTC

Guideline for the management of neurogenic bowel dysfunction in spinal cord injury/disease – Spinal Cord (if the link is paywalled, try this one)

Genetic testing identified a disease-causing variant in 10% of unexplained cardiac arrest survivors.

1 Apr, 2022 | 08:47h | UTC

Importance of genetic testing in cardiac arrest – European Heart Journal

Commentary on Twitter

🫀Importance of genetic testing in unexplained cardiac arrest (UCA)

♦️Genetic testing identifies a disease-causing variant in 🔟% of UCA

♦️Majority of variants located in genes associated with cardiomyopathy in absence of a diagnosis#CardioTwitter

🔗https://t.co/tLcqeDPx1S pic.twitter.com/rTbN1W86oa

— 𝗔𝗯𝗱𝗲𝗹𝘀𝗮𝗹𝗮𝗺 𝗕𝗲𝗻 𝗦𝗮𝗮𝘂𝗱 (@BenSaaud) March 30, 2022

Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study.

1 Apr, 2022 | 08:49h | UTC

Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study – The Lancet Diabetes & Endocrinology

Invited Commentary: The actual burden of obesity—accounting for multimorbidity – The Lancet Diabetes & Endocrinology (free registration required)

Commentary on Twitter

In the April Issue:
Body-mass index and risk of #obesity-related complex #multimorbidity: an observational multicohort study https://t.co/I2AqM9FmKd #BMI #OpenAccess pic.twitter.com/36f7J5VDZU

— The Lancet Diabetes & Endocrinology (@TheLancetEndo) March 30, 2022

Pharmacologic interventions for Kawasaki disease in children: A network meta-analysis of 56 randomized controlled trials.

1 Apr, 2022 | 08:45h | UTC

Pharmacologic interventions for Kawasaki disease in children: A network meta-analysis of 56 randomized controlled trials – eBioMedicine

Commentary: Network meta-analysis rates treatments for Kawasaki disease – medwire News

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive.

1 Apr, 2022 | 08:44h | UTC

IVF add-ons: why you should be cautious of these expensive procedures if you’re trying to conceive – The Conversation

Survey: Despite insufficient evidence of benefit, many fertility specialists still perform endometrial scratching before in vitro fertilization.

Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.

A Randomized Trial of Endometrial Scratching before In Vitro Fertilization – New England Journal of Medicine

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies

Randomized Trial: Acupuncture Not Effective for Improving the Likelihood of In Vitro Fertilization

Research: Transfer of Fresh versus Frozen Embryos in Ovulatory Women

Randomized trial: Freeze-all vs. fresh blastocyst transfer strategy during in vitro fertilization in women with regular menstrual cycles

Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions, 2nd edition.

1 Apr, 2022 | 08:43h | UTC

Strengthening systematic reviews in public health: guidance in the Cochrane Handbook for Systematic Reviews of Interventions, 2nd edition – Journal of Public Health

No flight, no bite: ‘Mosquito grounding’ bed net nearly halves malaria infection in Tanzanian children.

1 Apr, 2022 | 08:41h | UTC

News Release: No flight, no bite: ‘Mosquito grounding’ bed net nearly halves malaria infection in Tanzanian children – London School of Hygiene & Tropical Medicine

Original Study: Effectiveness and cost-effectiveness against malaria of three types of dual-active-ingredient long-lasting insecticidal nets (LLINs) compared with pyrethroid-only LLINs in Tanzania: a four-arm, cluster-randomised trial – The Lancet

Invited Commentary: A new generation of long-lasting insecticidal nets – The Lancet (free registration required)

Commentary on Twitter

Mosquitoes developing resistance to the insecticides used in bed nets became a large problem in the fight against malaria.

This study finds that nets treated with a new insecticide cut malaria rates in children *by almost half* compared to the usual ones.https://t.co/rRoyFzIhWf

— Max Roser (@MaxCRoser) March 28, 2022

Long-term follow-up of RCT: Nivolumab plus chemotherapy or ipilimumab in gastro-esophageal cancer.

1 Apr, 2022 | 08:37h | UTC

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer – Nature

Original Study: RCT: First-line nivolumab plus chemotherapy vs. chemotherapy alone for advanced gastric, gastro-esophageal junction, and esophageal adenocarcinoma.

Commentary on Twitter

New data from CheckMate 649 confirm that the OS benefit of nivolumab added to chemotherapy for advanced-stage gastroesophageal adenocarcinoma persists beyond 24 mo (HR 0.79; 95% CI 0.71-0.88); however, nivo+ipi did not improve OS vs chemotherapy alone: https://t.co/2Pom4zD7oX

— NatureRevClinOncol (@NatRevClinOncol) March 25, 2022