Daily Archives: March 4, 2022 | LinksMedicus Free Medical News & Perspectives

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

4 Mar, 2022 | 10:09h | UTC

News Release: RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Original study: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

Commentaries:

Arthritis drug reduces mortality in severe COVID-19, huge clinical trial finds – Science

Covid-19: Anti-inflammatory treatment baricitinib reduces deaths in patients admitted to hospital, finds trial – The BMJ

Another life-saving Covid drug identified – BBC

WHO recommends two new drugs (Baricitinib and Sotrovimab) to treat COVID-19.

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19

Commentary from the author on Twitter (thread – click for more)

RECOVERY pre-print: Baricitinib

Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis https://t.co/g0cNjaBzEL

— Martin Landray (@MartinLandray) March 3, 2022

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis.

4 Mar, 2022 | 10:07h | UTC

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis – The Lancet

Invited Commentary: Understanding of COVID-19 from infection–fatality ratio – The Lancet

Quantifying the effects of the COVID-19 pandemic on gender equality on health, social, and economic indicators.

4 Mar, 2022 | 10:04h | UTC

Quantifying the effects of the COVID-19 pandemic on gender equality on health, social, and economic indicators: a comprehensive review of data from March, 2020, to September, 2021 – The Lancet

Commentaries:

Gender equality and COVID-19: act now before it is too late – The Lancet

Social and economic effects of the COVID-19 pandemic threaten to reverse progress towards gender equality: study – The Lancet

Commentary on Twitter (thread – click for more)

NEW—The social & economic effects of the #COVID19 pandemic threaten to reverse progress in #GenderEquality by widening gender gaps that already existed in employment, education & gender-based violence, according to our new study in @TheLancet
🔗https://t.co/TCXStNPgRV pic.twitter.com/RAuDBRaNS7

— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) March 3, 2022

Updated WHO guidance conditionally recommends Molnupiravir for patients with non-severe covid-19 at highest risk of hospitalization.

4 Mar, 2022 | 09:57h | UTC

BMJ News Release: WHO recommends antiviral drug for patients with non-severe covid-19 at highest risk of hospital admission – BMJ

WHO News Release: WHO updates its treatment guidelines to include molnupiravir

See updated guidance: A living WHO guideline on drugs for covid-19 – BMJ

Editorial (just published): Molnupiravir’s authorisation was premature – The BMJ

RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.

Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.

[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

M-A: Efficacy of covid-19 vaccines in immunocompromised patients.

4 Mar, 2022 | 10:01h | UTC

Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis – The BMJ

News Release: Study suggests additional covid-19 vaccine doses for immunocompromised patients – BMJ Newsroom

Commentary on Twitter

NEW RESEARCH: Additional doses of covid-19 vaccine are recommended for immunocompromised patients, especially for organ transplant recipients who are least able to make antibodies to fight off coronavirus, suggests new research https://t.co/l2IWfSb0zd @sundar__raghav

— The BMJ (@bmj_latest) March 3, 2022

Viewpoint: Understanding and communicating uncertainty in achieving diagnostic excellence.

4 Mar, 2022 | 09:56h | UTC

Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence – JAMA (free for a limited period)

Cohort Study: Association between screen time exposure in children at 1 year of age and autism spectrum disorder at 3 years of age.

4 Mar, 2022 | 09:54h | UTC

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of Age: The Japan Environment and Children’s Study – JAMA Pediatrics

Commentary: Screen Time Linked to Autism Spectrum Disorder in Boys – HealthDay

M-A: Global prevalence of meeting screen time guidelines among children 5 years and younger.

Media and Young Minds – American Academy of Pediatrics

Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents – “children below 2 years age should not be exposed to any type of screen, whereas exposure should be limited to a maximum of one hour of supervised screen time per day for children 24-59 months age, and less than two hours per day for children 5-10 years age”.

Systematic Review: Arthroscopic surgery provides little or no clinically important benefit for patients with degenerative knee disease.

4 Mar, 2022 | 09:53h | UTC

Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears) – Cochrane Library

Summary: Arthroscopic surgery for degenerative knee disease – Cochrane Library

G uideline: Arthroscopic Meniscal Surgery

Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline

Randomized Trial: Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears

Study: Adverse Outcomes After Arthroscopic Partial Meniscectomy

Pre-post study: The introduction of a text-message alert system to alert volunteers close to a cardiac arrest patient at home was associated with increased survival to hospital discharge.

4 Mar, 2022 | 09:44h | UTC

Alert system-supported lay defibrillation and basic life-support for cardiac arrest at home – European Heart Journal

Editorial: Volunteer first responders for out-of-hospital cardiac arrest at home: the missing link for improved survival? – European Heart Journal

Commentary on Twitter

For patients with a cardiac arrest at home, an alert system that includes nearby volunteers activated by the ambulance dispatch centre and many easily accessible AEDs saves lives https://t.co/0jfD9LsKip @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/pjPk3NJDla

— European Society of Cardiology Journals (@ESC_Journals) December 20, 2021

A guideline for the outpatient management of glycemic control in people with cancer.

4 Mar, 2022 | 08:56h | UTC

A guideline for the outpatient management of glycaemic control in people with cancer – Diabetic Medicine

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

4 Mar, 2022 | 09:41h | UTC

Clinic, Home, and Kiosk Blood Pressure Measurements for Diagnosing Hypertension: a Randomized Diagnostic Study – Journal of General Internal Medicine

Commentary: Home blood pressure monitoring may provide the basis for accurate diagnoses of hypertension – Kaiser Permanente

ACR Guidelines for the Treatment of Juvenile Idiopathic Arthritis.

4 Mar, 2022 | 08:58h | UTC

News Release: The American College of Rheumatology releases two updated guidelines for treatment of juvenile idiopathic arthritis – American College of Rheumatology

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging – Arthritis & Rheumatology

2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Therapeutic Approaches for Oligoarthritis, Temporomandibular Joint Arthritis, and Systemic Juvenile Idiopathic Arthritis

AAP Clinical Report: Recognition and management of cardiovascular insufficiency in the very low birth weight newborn.

4 Mar, 2022 | 08:54h | UTC

Recognition and Management of Cardiovascular Insufficiency in the Very Low Birth Weight Newborn – Pediatrics

Risk of cancer with angiotensin-receptor blockers increases with cumulative exposure: Meta-regression analysis of randomized trials.

4 Mar, 2022 | 08:49h | UTC

Risk of cancer with angiotensin-receptor blockers increases with increasing cumulative exposure: Meta-regression analysis of randomized trials – PLOS One

Commentary: ARBs and Cancer Risk: New Meta-Analysis Raises Questions Again – Medscape (free registration required)

JCS/JHRS guideline focused update on non-pharmacotherapy of cardiac arrhythmias.

4 Mar, 2022 | 08:51h | UTC

JCS/JHRS 2021 guideline focused update on non-pharmacotherapy of cardiac arrhythmias – Journal of Arrythmia

Systematic Review: Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis.

4 Mar, 2022 | 08:46h | UTC

Topical pharmacologic interventions versus placebo for epidemic keratoconjunctivitis – Cochrane Library

Summary: What are the benefits and risks of topical medications for treating epidemic keratoconjunctivitis? – Cochrane Library

Nudging within learning health systems: next generation decision support to improve cardiovascular care.

4 Mar, 2022 | 08:50h | UTC

Nudging within learning health systems: next generation decision support to improve cardiovascular care – European Heart Journal

Commentary on Twitter

Nudging within learning health systems: next generation decision support to improve cardiovascular care https://t.co/TbPSqBDZVR @escardio #EHJ #ESCYoung #cardiotwitter @ehj_ed @rladeiraslopes pic.twitter.com/6yJB9Rcu92

— European Society of Cardiology Journals (@ESC_Journals) March 3, 2022

Systematic Review: Interventions for minimal change disease in adults with nephrotic syndrome.

4 Mar, 2022 | 08:47h | UTC

Interventions for minimal change disease in adults with nephrotic syndrome – Cochrane Library

Commentary: Interventions for minimal change disease in adults with nephrotic syndrome – Cochrane Library

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

4 Mar, 2022 | 08:45h | UTC

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts – The Lancet Public Health

Commentaries:

Meta-analysis of 15 studies reports new findings on how many daily walking steps needed for longevity benefit – University of Massachusetts Amherst

Living a long life is a multi-step process – The Lancet Public Health

Cohort Study: Mental health outcomes in transgender and nonbinary youths receiving gender-affirming care.

4 Mar, 2022 | 08:43h | UTC

Mental Health Outcomes in Transgender and Nonbinary Youths Receiving Gender-Affirming Care – JAMA Network Open

Invited Commentary: A Multipronged, Evidence-Based Approach to Improving Mental Health Among Transgender and Gender-Diverse Youth – JAMA Network Open

Podcast: Obesity medicine pearls.

4 Mar, 2022 | 08:43h | UTC

#324: Obesity Medicine FAQ with Dr. Fatima Cody Stanford – The Curbsiders

JAMA Guide to Statistics and Methods: Causal Directed Acyclic Graphs.

4 Mar, 2022 | 08:40h | UTC

Causal Directed Acyclic Graphs – JAMA (free for a limited period)

Review: Implementing machine learning in medicine.

4 Mar, 2022 | 08:42h | UTC

Implementing machine learning in medicine – Canadian Medical Association Journal

A Clinician’s Guide to Artificial Intelligence (AI): Why and How Primary Care Should Lead the Health Care AI Revolution – The Journal of the American Board of Family Medicine

Primer for artificial intelligence in primary care.

A Clinician’s Guide to Artificial Intelligence: How to Critically Appraise Machine Learning Studies

Review | AI and the cardiologist: when mind, heart and machine unite.

Review: Artificial intelligence in health and medicine.

Artificial intelligence projects in healthcare: 10 practical tips for success in a clinical environment.

WHO issues first global report on Artificial Intelligence (AI) in health and six guiding principles for its design and use.

Opinion | AI-facilitated health care requires education of clinicians

Welcoming new guidelines for AI clinical research

Diagnosis, management and therapeutic strategies for congenital long QT syndrome.

4 Mar, 2022 | 08:39h | UTC

Diagnosis, management and therapeutic strategies for congenital long QT syndrome – Heart

Commentary on Twitter

Excellent review on congential long QT syndrome:

Diagnosis, management and therapeutic strategies for congenital long QT syndromehttps://t.co/FECINw9k7g pic.twitter.com/O4s5GwKK3O

— Heart_BMJ (@Heart_BMJ) June 19, 2021

Renal compression in heart failure: the renal tamponade hypothesis.

4 Mar, 2022 | 08:36h | UTC

Renal Compression in Heart Failure: The Renal Tamponade Hypothesis – JACC: Heart Failure

Summary: Review of Renal Compression in Heart Failure: Key Points – American College of Cardiology

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