Daily Archives: November 12, 2021
RCT: BBV152 (India’s COVAXIN) has an overall vaccine efficacy of 77.8% against symptomatic Covid-19 in adults.
12 Nov, 2021 | 10:43h | UTCInvited Commentary: Inactivated SARS-CoV-2 vaccine (BBV152)-induced protection against symptomatic COVID-19 – The Lancet
Related: WHO issues emergency use approval for India’s Covaxin.
Commentary on Twitter
NEW—Interim data from a phase 3 trial of #BBV152, a COVID-19 vaccine developed in India, suggests it is safe and two doses offer 77.8% protection against symptomatic #COVID19. https://t.co/QWtz0AWd1X
— The Lancet (@TheLancet) November 11, 2021
Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.
12 Nov, 2021 | 10:39h | UTCRelated:
Study: Children and young people remain at low risk of COVID-19 mortality
Commentaries on Twitter
Just published @NatureMedicine
An in-depth analysis of the 25 children who died from Covid in England during the 1st year of the pandemichttps://t.co/QK3gk1BXy5
Great that 99.995% of children w/ a positive test survived (not what is driving the need for 💉in kids) pic.twitter.com/moXKl8ysmA— Eric Topol (@EricTopol) November 11, 2021
A clinical review of all pediatric deaths in England from March 2020 to February 2021 attributes 25 deaths to SARS-CoV-2 infection and identifies risk factors to guide interventions, according to a @NatureMedicine article. https://t.co/Bpjhf5sgow pic.twitter.com/v24Zf9CsXK
— Nature Portfolio (@NaturePortfolio) November 11, 2021
Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.
12 Nov, 2021 | 10:41h | UTC
Commentary from the author on Twitter (thread – click for more)
Honoured to lead this Delphi on Infection Control in ICU for SARS-CoV-2 with global experts https://t.co/39NTHgfyZR @Drnasap @ElieAzoulay5 @jigidivatia @AlhazzaniW @NaomiHammond @criticcaredoc @YaseenarabiYa @Laura_Evans_206 @FlaviaSepsis @AndersPerner @jlvincen @TheLancetInfDis pic.twitter.com/RWw6vXcHb0
— Sheila Myatra (@SheilaMyatra) November 11, 2021
Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.
12 Nov, 2021 | 10:32h | UTCRelated:
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
The COVID pandemic has harmed researcher productivity – and mental health – “Surveys show that women, parents of young children and people of color are most affected by pandemic-related disruptions and need more support”.
12 Nov, 2021 | 10:35h | UTCThe COVID pandemic has harmed researcher productivity – and mental health – Nature
Boosting immunity to COVID-19 vaccines – “New studies highlight the immunological benefits of COVID-19 vaccine boosters, but questions remain over how to best make use of a limited global supply”.
12 Nov, 2021 | 10:37h | UTCBoosting immunity to COVID-19 vaccines – Nature Medicine
ERS Guidelines: High-flow nasal cannula in acute respiratory failure.
12 Nov, 2021 | 10:29h | UTC
Map: The world according to covid vaccine coverage.
12 Nov, 2021 | 10:34h | UTCThe world according to covid vaccine coverage – The BMJ
Commentary on Twitter
A year since the first covid vaccines were announced, rollouts are under way all over the world—to differing degrees.
This map shows the percentage of national population to have received two doses of covid vaccinehttps://t.co/rIU3qeWXIK @munkeatlooi pic.twitter.com/zZHr1XXBe8
— The BMJ (@bmj_latest) November 11, 2021
2022 ASA Guidelines for Management of the Difficult Airway.
12 Nov, 2021 | 10:31h | UTCRelated:
Consensus Guideline: Pediatric Airway Management in COVID-19 Patients
Guidelines for Awake Tracheal Intubation in Adults
Position Paper: Management of Unanticipated Difficult Airways in Children in Anesthetic Practice
Review: Difficult Airway Management Algorithms (several resources on the subject)
The Difficult Airway Trolley: A Narrative Review and Practical Guide
WHO, CDC | Global progress against measles threatened amidst COVID-19 pandemic.
12 Nov, 2021 | 10:27h | UTCNews Release: Global progress against measles threatened amidst COVID-19 pandemic – World Health Organization
Commentary on Twitter (thread – click for more)
While reported #measles cases have fallen compared to previous years, progress toward measles elimination continues to decline and the risk of outbreaks is mounting, according to a 🆕 report from @CDCgov & WHO.
👉 https://t.co/EjRVRexcGd pic.twitter.com/KnBU5RZn5i
— World Health Organization (WHO) (@WHO) November 10, 2021
Series: Diversity, equity, and inclusion in medical research.
12 Nov, 2021 | 10:23h | UTCHomepage: DEI in medical research – Nature Medicine
Editorial: Diversity, equity and inclusion: we are in it for the long run
Opinion articles:
Role of funders in addressing the continued lack of diversity in science and medicine
The US National Institutes of Health approach to inclusive excellence
Promoting diversity and inclusion in STEMM starts at the top
A commitment to scientific equity from a philanthropic funder
Commentary on Twitter (thread – click for more)
Today we publish 4 comments and an editorial that launch a new series: #DEI in medical research.
Diversity, equity and inclusion are critically important if medical research is to deliver on its goal to improve human health.
A thread…
(1 of 6)https://t.co/khtyXipNOY pic.twitter.com/5EG0wXBKSt— Nature Medicine (@NatureMedicine) November 11, 2021
EMA Recommendation: Dapagliflozin 5mg should no longer be used for the treatment of Type 1 Diabetes Mellitus due to increased risk of diabetic ketoacidosis.
12 Nov, 2021 | 10:28h | UTC
Cohort study: In patients with nonalcoholic steatohepatitis and obesity, bariatric surgery was associated with lower risk of incident major adverse liver outcomes and major adverse cardiovascular events.
12 Nov, 2021 | 10:24h | UTCAssociation of Bariatric Surgery With Major Adverse Liver and Cardiovascular Outcomes in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis – JAMA (free for a limited period)
Editorial: Bariatric Surgery as a Strategy for Improving Outcomes in Nonalcoholic Steatohepatitis – JAMA (free for a limited period)
Commentary on Twitter
Study found, among patients with nonalcoholic steatohepatitis and obesity, bariatric surgery, vs nonsurgical management, was associated with a significantly lower risk of incident major adverse liver outcomes and major adverse cardiovascular events https://t.co/Ps23yfjncq
— JAMA (@JAMA_current) November 11, 2021
Among patients with cancer who received decompressive G-tubes for nutrition or malignant bowel obstruction, nearly half presented with stage IV disease and died within one month of placement.
12 Nov, 2021 | 09:55h | UTCCommentary: Risks and Benefits Associated With Gastrostomy Tubes for Patients With Cancer – The ASCO Post
M-A: Efficacy of amisulpride for depressive symptoms in individuals with mental disorders.
12 Nov, 2021 | 10:21h | UTC
Commentary on Twitter
MA: Amisulpride 50 mg/day was associated with a larger reduction of depressive symptoms vs. placebo (SMD= −0.70; −0.92 to −0.49; I2=0.0%), and was found to be comparable to SSRIs (SMD= −0.08; −0.23 to 0.06; I2=0.0%) in dysthymia https://t.co/schW6PbZQK pic.twitter.com/p7St9pE0Cr
— P𝘧OL (@psychopharmacol) November 7, 2021
Some immune checkpoint inhibitors can cause serious arrhythmias and myocarditis.
12 Nov, 2021 | 09:57h | UTCOriginal study: Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis – Circulation (link to abstract – $ for full-text)
Related:
Cohort study: Among older adults with diabetes who were hospitalized for common medical conditions, intensification of diabetes medications at hospital discharge was associated with an increased short-term risk of severe hypoglycemia events but was not associated with improved glycemic control.
12 Nov, 2021 | 09:51h | UTC
Cohort study: After an episode of severe hypoglycemia in older adults with diabetes, sulfonylurea or insulin treatment deintensification occurred in fewer than 50% of episodes.
12 Nov, 2021 | 09:53h | UTC
Commentary on Twitter
Less than half of older adults with diabetes seen in the ED or hospitalized for hypoglycemia had high-risk medications (sulfonylureas or insulin) deintensified in the following 100 days, although deintensification rates may be increasing over time. https://t.co/X0TAbUxcIh
— JAMA Network Open (@JAMANetworkOpen) November 2, 2021
Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis – “Each day of antibiotic therapy was associated with 4% increased odds of experiencing an adverse event”.
12 Nov, 2021 | 09:47h | UTC
Commentary on Twitter
Each additional day of antibiotic therapy is associated with measurable antibiotic harm, particularly adverse events
🆕💥💥 @CMIJournal @BRxAD et Al
Estimating daily antibiotic harms: an umbrella review with individual study meta-analysis #IDTwitter https://t.co/ERlUZ1ict6 pic.twitter.com/KOWU4PhSzK— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) November 11, 2021
White-Coat Hypertension: Pathophysiological and Clinical Aspects.
12 Nov, 2021 | 09:48h | UTCWhite-Coat Hypertension: Pathophysiological and Clinical Aspects: Excellence Award for Hypertension Research 2020 – Hypertension (free for a limited period)