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Daily Archives: November 5, 2021

Study compares the decline in effectiveness for Moderna, Pfizer, and Janssen vaccines and consequences for mortality.

5 Nov, 2021 | 09:59h | UTC

Original study: SARS-CoV-2 vaccine protection and deaths among US veterans during 2021 – Science

News release: Breakthrough Infection Study Compares Decline in Vaccine Effectiveness and Consequences for Mortality – Public Health Institute

 

Commentary on Twitter

 

Review: SARS-CoV-2 indoor air transmission is a threat that can be addressed with science.

5 Nov, 2021 | 09:55h | UTC

SARS-CoV-2 indoor air transmission is a threat that can be addressed with science – Proceedings of the National Academies of Sciences

Related:

Ten scientific reasons in support of airborne transmission of SARS-CoV-2

Editorial: Covid-19 has redefined airborne transmission

Covid-19: What do we know about airborne transmission of SARS-CoV-2?

Real-world data show that filters clean COVID-causing virus from air.

Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”

Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.

We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

It’s not just SARS-CoV-2: Most respiratory viruses spread by aerosols.

 

Commentary on Twitter

 

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

5 Nov, 2021 | 09:56h | UTC

Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries – The BMJ

Related:

Global Covid-19 deaths surpass five million.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary from the author on Twitter (thread – click for more)

 

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

5 Nov, 2021 | 09:51h | UTC

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first – NPR

Related:

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Debate: Are vaccine passports and covid passes a valid alternative to lockdown?

5 Nov, 2021 | 09:53h | UTC

Are vaccine passports and covid passes a valid alternative to lockdown? – The BMJ

News Release: Covid passes: the best way of preventing another lockdown or a threat to civil freedoms and rights? – BMJ

 

Clinical Care Pathway for the Risk Stratification and Management of Patients with Nonalcoholic Fatty Liver Disease.

5 Nov, 2021 | 09:50h | UTC

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

News release: International experts develop Clinical Care Pathway in response to NASH epidemic – American Gastroenterology Association

Related:

Non-alcoholic fatty liver disease: A patient guideline.

State of the art review: Management of non-alcoholic fatty liver disease

M-A: Non-alcoholic fatty liver disease linked to increased risk of fatal and non-fatal cardiovascular events.

M-A: non-invasive tests for advanced fibrosis can reduce the need for biopsy in patients with non-alcoholic fatty liver disease.

Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.

 

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

5 Nov, 2021 | 09:46h | UTC

Renal Denervation for Hypertension: A Systematic Review and Meta-Analysis of Randomized, Blinded, Placebo-Controlled Trials – JACC: Cardiovascular Interventions

Commentaries:

Meta-Analysis of Renal Denervation for Hypertension – American College of Cardiology

Is Renal Denervation a Useful Strategy in BP Management? – American College of Cardiology

Related:

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

RCT: In patients with three-vessel coronary artery disease, an FFR–guided PCI strategy was NOT noninferior to coronary bypass surgery – The 1-year incidence of the composite primary end point (death, myocardial infarction, or stroke) was 7.3% in the FFR-guided PCI group and 5.2% in the CABG group.

5 Nov, 2021 | 09:49h | UTC

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery – New England Journal of Medicine

Commentaries:

FAME 3: PCI Fails to Demonstrate Noninferiority to Surgery in Three-Vessel CAD – TCTMD

FAME 3: FFR-Guided PCI vs. CABG in Patients With Three-Vessel CAD – American College of Cardiology

Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 3 – FAME 3 – American College of Cardiology

 

Commentary on Twitter

 

Cluster RCT: In older adults with advanced cancer, a geriatric assessment program reduced the toxic effects of cancer treatment.

5 Nov, 2021 | 09:48h | UTC

Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study – The Lancet

News Release: Less Chemotherapy, Personalized Care: Wilmot Study Reinforces Major Strides in Geriatric Oncology – University of Rochester Medical Center

Related:

RCT: A geriatric assessment–driven intervention can reduce chemotherapy-related toxic effects in older adults with cancer.

Perspective: A Cancer Care Approach Tailored to The Elderly May Have Better Results

 

Commentary from the author on Twitter (thread – click for more)

 

Things We Do for No Reason: Prescribing Tramadol for Inpatients in Pain.

5 Nov, 2021 | 09:44h | UTC

Things We Do for No Reason: Prescribing Tramadol for Inpatients in Pain – Journal of Hospital Medicine

Related:

Large observational study suggests Tramadol is associated with increased risk of adverse outcomes compared to Codeine.

Tramadol: Where do we go from here? – “Tramadol’s unpredictability, unique potential harms, and lack of advantage over other opioids or NSAIDs are now well recognized”.

Cohort Study: Chronic Use of Tramadol After Acute Pain Episode

 

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