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Daily Archives: September 15, 2021

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

15 Sep, 2021 | 10:01h | UTC

Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial – The Lancet

Invited commentary: Daily antigen testing to reduce disruption when schools return – The Lancet

 

RCT: Remdesivir does not improve outcomes in patients admitted to hospital with COVID-19.

15 Sep, 2021 | 09:59h | UTC

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial – The Lancet Infectious Diseases

Invited commentary: Remdesivir, on the road to DisCoVeRy – The Lancet Infectious Diseases

Related:

Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.

WHO Solidarity Trial: Remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19

 

Review | Prevention of host-to-host transmission by SARS-CoV-2 vaccines.

15 Sep, 2021 | 09:16h | UTC

Prevention of host-to-host transmission by SARS-CoV-2 vaccines – The Lancet Infectious Diseases

Related:

Study ties COVID vaccines to lower transmission rates.

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

 

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

15 Sep, 2021 | 09:07h | UTC

Ivermectin: Cochrane’s most talked about review so far, ever. Why? – Cochrane Library

Original review: Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

 

Commentary on Twitter

 

Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.

15 Sep, 2021 | 08:56h | UTC

Homepage: FIGO Working Group for Preterm Birth – Good Practice Recommendations – International Journal of Gynecology & Obstetrics

Editorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes

FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies

FIGO good practice recommendations on progestogens for prevention of preterm delivery

FIGO good practice recommendations on cervical cerclage for prevention of preterm birth

FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth

FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

FIGO good practice recommendations on delayed umbilical cord clamping

 

CDC report finds unvaccinated people are 11 times more likely to die of COVID-19.

15 Sep, 2021 | 09:09h | UTC

Unvaccinated People Are 11 Times More Likely To Die Of COVID-19, New Research Finds – NPR

Original study: Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, April 4–July 17, 2021 – CDC Morbidity and Mortality Weekly Report

 

Commentary on Twitter

 

The tangled history of mRNA vaccines.

15 Sep, 2021 | 09:06h | UTC

The tangled history of mRNA vaccines – Nature

Related:

mRNA vaccines for infectious diseases: principles, delivery and clinical translation.

After COVID-19 successes, researchers push to develop mRNA vaccines for other infectious diseases and cancer.

 

Commentary on Twitter

 

How COVID is derailing the fight against HIV, TB and malaria.

15 Sep, 2021 | 09:01h | UTC

How COVID is derailing the fight against HIV, TB and malaria – Nature

Related:

How COVID hurt the fight against other dangerous diseases

World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis

WHO: Benefits of continuing to provide life-saving HIV services outweigh the risk of COVID-19 transmission by 100 to 1

 

The USPSTF maintains the recommendation to screen for chlamydia and gonorrhea in all sexually active women 24 years or younger and in women 25 years or older who are at increased risk for infection.

15 Sep, 2021 | 08:57h | UTC

Final Recommendation Statement: Screening for Chlamydia and Gonorrhea – U.S. Preventive Services Task Force

Editorial: Screening for Chlamydia and Gonorrhea – JAMA

Evidence Report : Screening for Chlamydial and Gonococcal Infections: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Author Interview: USPSTF Recommendation: Screening for Chlamydia and Gonorrhea

JAMA Patient Page: Screening for Chlamydia and Gonorrhea

 

Systematic Review: Partial breast irradiation versus whole breast radiotherapy for early breast cancer.

15 Sep, 2021 | 08:46h | UTC

Partial breast irradiation versus whole breast radiotherapy for early breast cancer – Cochrane Library

 

Commentary on Twitter

 

RCT: Effect of Camrelizumab vs. placebo added to chemotherapy on survival and progression-free survival in patients with advanced or metastatic esophageal squamous cell carcinoma.

15 Sep, 2021 | 08:51h | UTC

Effect of Camrelizumab vs Placebo Added to Chemotherapy on Survival and Progression-Free Survival in Patients With Advanced or Metastatic Esophageal Squamous Cell Carcinoma: The ESCORT-1st Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Immunotherapy for Advanced Esophageal Squamous Cell Carcinoma—Renewed Enthusiasm and a Lingering Challenge – JAMA Oncology (free for a limited period)

 

Commentary on Twitter

 

Review | Recommendations and Nutritional Considerations for Female Athletes: Health and Performance.

15 Sep, 2021 | 08:49h | UTC

Recommendations and Nutritional Considerations for Female Athletes: Health and Performance – Sports Medicine

 

Management of high-risk pulmonary embolism in pregnancy.

15 Sep, 2021 | 08:43h | UTC

Management of high-risk pulmonary embolism in pregnancy – Thrombosis Research

 

Systematic Review: Does hair removal before surgery prevent infections after surgery?

15 Sep, 2021 | 08:47h | UTC

Summary: Does hair removal before surgery prevent infections after surgery? – Cochrane Library

Original study: Preoperative hair removal to reduce surgical site infection – Cochrane Library

 

Commentary on Twitter

 

An update on prevention of malaria in travelers.

15 Sep, 2021 | 08:39h | UTC

An update on prevention of malaria in travelers – Therapeutic Advances in Infectious Disease

Related: CDC Yellow Book

 

RCT: Prophylactic steroids prevent hypocalcemia and voice dysfunction in patients undergoing thyroidectomy.

15 Sep, 2021 | 08:44h | UTC

Use of Prophylactic Steroids to Prevent Hypocalcemia and Voice Dysfunction in Patients Undergoing Thyroidectomy: A Randomized Clinical Trial – JAMA Otolaryngology – Head & Neck Surgery (link to abstract – $ for full-text)

Author interview: Prophylactic Steroids for Postthyroidectomy Hypocalcemia and Voice Dysfunction

Commentary: IV Steroid Before Thyroidectomy Prevents Complications — One dose of dexamethasone reduced hypocalcemia, voice issues – MedPage Today (free registration required)

 

Commentary on Twitter

 

Update on the management of overactive bladder.

15 Sep, 2021 | 08:42h | UTC

Update on the management of overactive bladder – Therapeutic Advances in Urology

 

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