Daily Archives: July 29, 2021
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
29 Jul, 2021 | 11:38h | UTCIvermectin for preventing and treating COVID‐19 – Cochrane Library
Summary: Ivermectin for preventing and treating COVID-19 – Cochrane Library
Commentary: Ivermectin treatment in humans for COVID-19 – Liverpool School of Tropical Medicine
Related:
Why was a major study on ivermectin for covid-19 just retracted?
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Updated WHO SAGE roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply.
29 Jul, 2021 | 11:34h | UTC
PRINCIPLE RCT: Doxycycline does not improve outcomes in outpatients with suspected COVID-19 at high risk for adverse outcomes.
29 Jul, 2021 | 11:36h | UTCCommentary: PRINCIPLE: a community-based COVID-19 platform trial – The Lancet Respiratory Medicine
Commentary on Twitter
NEW Research—In suspected #COVID19 in the community, doxycycline was not associated with clinically meaningful reductions in time to recovery or hospital admissions or deaths, and should not be used as a routine treatment
Read the PRINCIPLE trial here https://t.co/Osw1hZLCaY pic.twitter.com/Q3VrpAO9cm
— The Lancet Respiratory Medicine (@LancetRespirMed) July 28, 2021
Covid-19 breakthrough infections in vaccinated health care workers.
29 Jul, 2021 | 11:30h | UTCCovid-19 Breakthrough Infections in Vaccinated Health Care Workers – New England Journal of Medicine
Commentary on Twitter (thread – click for more)
Very important @NEJM paper today on breakthrough infections (BTI) post-vaccination in Israeli health care workers.
5 key points:
1. Of ~1500 people, 0.4% had BIs, sequenced to be Alpha 85% (this was pre-Delta)https://t.co/l69DK5Cbv4 pic.twitter.com/zDSq5e0baN— Eric Topol (@EricTopol) July 28, 2021
COVID-19 false dichotomies and a comprehensive review of the evidence regarding public health, COVID-19 symptomatology, SARS-CoV-2 transmission, mask wearing, and reinfection.
29 Jul, 2021 | 11:32h | UTC
Commentary on Twitter
A false dichotomy is a logical fallacy that involves presenting only two views or options when other possibilities exist.
Here are 6 COVID-19 false dichotomies:https://t.co/7uYry96l2q by @KevinEscandonMD @angie_rasmussen @BogochIsaac @EpiEllie @SaskiaPopescu @KindrachukJason pic.twitter.com/mHanKxObmt
— Dr. Jonathan N. Stea (@jonathanstea) July 28, 2021
COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.
29 Jul, 2021 | 11:21h | UTCCOVID vaccines slash viral spread – but Delta is an unknown – Nature
What is a breakthrough infection? 6 questions answered about catching COVID-19 after vaccination.
29 Jul, 2021 | 11:28h | UTC
2021 ACC expert consensus decision pathway for cardiovascular risk reduction in patients with persistent hypertriglyceridemia.
29 Jul, 2021 | 11:15h | UTCKey points: ACC Consensus on ASCVD Risk Reduction in Hypertriglyceridemia – American College of Cardiology
Commentary on Twitter
The ACC Expert Consensus Decision Pathway highlights 9️⃣ key points to remember on the management of atherosclerotic #CVD risk reduction in patients with persistent hypertriglyceridemia. Learn more here: https://t.co/zTx4gsIQS2 #ASCVD #cvCAD #Diabetes @virani_md @PamelaBMorris pic.twitter.com/Zjo4wmeZVj
— American College of Cardiology (@ACCinTouch) July 28, 2021
Efficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show.
29 Jul, 2021 | 11:19h | UTCEfficacy of Pfizer/BioNTech Covid vaccine slips to 84% after six months, data show – STAT
Original study (preprint): Six Month Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine – medRxiv
Commentary on Twitter (thread – click for more)
6-month followup for major BNT-Pfizer vax trial. While still blinded, overall vaccine efficacy was:
– against symptomatic Covid-19: 91.1% (89-93)
– against severe Covid-19: 96.7% VE (80-99.9)…1/nhttps://t.co/B6JVxJeS2C (preprint) pic.twitter.com/KlwwjoqrfZ
— Hilda Bastian, PhD (@hildabast) July 28, 2021
ESC Position Paper: Cardiac, renal, and metabolic effects of SGLT2 inhibitors.
29 Jul, 2021 | 11:13h | UTC
Research aims to stop fuzzy phrasing, medical errors in surgery.
29 Jul, 2021 | 11:09h | UTCResearch aims to stop fuzzy phrasing, medical errors in surgery – University of Kansas
Original study: Semantically Ambiguous Language in the Teaching Operating Room – Journal of Surgical Education (link to abstract – $ for full-text)
Cohort study: Postdiagnosis smoking cessation linked to reduced risk for lung cancer progression and mortality.
29 Jul, 2021 | 11:12h | UTCPostdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Mortality: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Never too late: Cancer centers push patients to quit smoking – STAT
Summary for Patients: Postdiagnosis Smoking Cessation and Reduced Risk for Lung Cancer Progression and Death
Commentary on Twitter
Research led by Paul Brennan, PhD, @mahdi_iarc, et al. of @IARCWHO found that quitting smoking after a #lungcancer diagnosis may extend life without cancer recurrence https://t.co/b0YAqqt7FM. pic.twitter.com/Sjl3ipoXLQ
— Annals of Int Med (@AnnalsofIM) July 26, 2021
Olympic Pseudoscience – Tokyo Edition.
29 Jul, 2021 | 11:08h | UTCOlympic Pseudoscience – Tokyo Edition – Science Based Medicine
Evidence Analysis: Is piperacillin-tazobactam safe in patients with penicillin allergy?
29 Jul, 2021 | 11:05h | UTCIs piperacillin-tazobactam safe in patients with penicillin allergy? – PulmCrit
M-A: Global prevalence of turnover intention among intensive care nurses – “27% of the intensive care nurses had the intention to leave worldwide”.
29 Jul, 2021 | 11:07h | UTCGlobal prevalence of turnover intention among intensive care nurses: A meta-analysis – Nursing in Critical Care (link to abstract – $ for full-text)
Commentary on Twitter
Every fourth ICU nurse has the intention to leave, according to a meta-analysis incl 23,140 nurses from 23 countries in 18 studies (2007-2020), even higher in younger nurses.
Authors recommend social support, better working conditions, and evaluationshttps://t.co/f19iD0GLPL pic.twitter.com/NIM9nrVKiL— Peter Nydahl (@NydahlPeter) July 28, 2021
ASTRO Guideline: Radiation therapy for treatment of soft tissue sarcoma in adults.
29 Jul, 2021 | 10:54h | UTCNews release: Astro Issues Clinical Guideline on Radiation Therapy for Soft Tissue Sarcoma in Adults
Cohort study: Evidence of a potentially inappropriate and harmful prescribing cascade of gabapentinoid followed by a diuretic among older adults with lower back pain.
29 Jul, 2021 | 11:02h | UTCEvidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
Related:
Are you the victim of a prescribing cascade?
Prescribing Cascade in a Cardiology Practice
ESMO Guidelines: Soft tissue and visceral sarcomas.
29 Jul, 2021 | 10:53h | UTC
Effect of systemic hydrocortisone initiated 7 to 14 days after birth in ventilated preterm infants on mortality and neurodevelopment at 2 years’ corrected age: follow-up of a randomized clinical trial.
29 Jul, 2021 | 10:57h | UTCEffect of Systemic Hydrocortisone Initiated 7 to 14 Days After Birth in Ventilated Preterm Infants on Mortality and Neurodevelopment at 2 Years’ Corrected Age: Follow-up of a Randomized Clinical Trial – JAMA (free for a limited period)
Review: Lipoprotein(a) and Cardiovascular Diseases.
29 Jul, 2021 | 10:56h | UTCLipoprotein(a) and Cardiovascular Diseases – JAMA (free for a limited period)