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Daily Archives: July 26, 2021

[Preprint] RCT: In patients with COVID-19 and severe hypoxia, dexamethasone 12 mg did NOT result in statistically significant improved outcomes compared to dexamethasone 6 mg – “Mortality at 28 days was 27.1% and 32.3% in patients assigned to 12 mg and 6 mg, respectively (adjusted relative risk 0.86, 99% CI, 0.68-1.08)”.

26 Jul, 2021 | 03:01h | UTC

Dexamethasone 12 mg versus 6 mg for patients with COVID-19 and severe hypoxia: an international, randomized, blinded trial – medRxiv

 

Cohort study: Neurological manifestations of SARS-CoV-2 infection in hospitalized children and adolescents in the UK – “around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection”.

26 Jul, 2021 | 02:58h | UTC

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study – The Lancet Child & Adolescent Health

Commentaries:

Neuroinflammation triggered by SARS-CoV-2 infection: syndromes and therapies – The Lancet Child & Adolescent Health

New UK study reveals extent of brain complications in children hospitalized with COVID-19 – University of Liverpool

 

Commentary on Twitter

 

Large cohort study finds one in two hospitalized COVID-19 patients develop a complication.

26 Jul, 2021 | 03:00h | UTC

Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study – The Lancet

Commentaries:

Landmark study finds one in two hospitalised COVID-19 patients develop a complication – National Institute for Health Research

In-hospital complications associated with COVID-19 – The Lancet

CV Complications Common in Hospitalized COVID-19 Patients – TCTMD

Almost Half of Patients Admitted With COVID-19 Have Complications – HealthDay

 

Commentary on Twitter (thread – click for more)

 

Study: Lateral flow antigen testing can rapidly and accurately detect early COVID-19 among patients presenting with flu-like illness and can be a plausible alternative to RT-PCR.

26 Jul, 2021 | 02:56h | UTC

Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2) – EClinicalMedicine

News release: Lateral flow tests are 95% effective at detecting Covid-19 when used at the onset of symptoms – University of Oxford

Related:

Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.

Rapid point-of-care tests for diagnosing COVID-19 infection: the latest Cochrane evidence

 

Commentary on Twitter (thread – click for more)

 

M-A: Psychiatric patients at increased risk of COVID-19 hospitalization and mortality.

26 Jul, 2021 | 02:57h | UTC

News release: Psychiatric patients at increased risk of COVID-19 hospitalization and mortality – European College of Neuropsychopharmacology

Original article: Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis – The Lancet Psychiatry

 

Study: Among kidney transplant recipients who did not respond after 2 doses, a third dose of an mRNA-1273 vaccine induced a serologic response in 49% of patients.

26 Jul, 2021 | 02:54h | UTC

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses – JAMA

Commentary: Case Mounts for COVID Vaccine Boosters in Kidney Transplant Recipients – MedPage Today (free registration required)

Related:

Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

[Preprint] 3rd AstraZeneca shot gives strong immunity.

 

Commentary on Twitter

 

Case report: Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult.

26 Jul, 2021 | 02:52h | UTC

Kawasaki-like multisystem inflammatory syndrome associated with SARS-CoV-2 infection in an adult – BMJ Case Reports

Related:

Case report: Multisystem inflammatory syndrome in an adult after SARS-CoV-2 infection.

Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection

Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection

Case Reports: 2 Adults with Kawasaki-like Multisystem Inflammatory Syndrome Associated with COVID-19

 

Position paper: Advancing precision medicine for acute respiratory distress syndrome.

26 Jul, 2021 | 02:28h | UTC

Advancing precision medicine for acute respiratory distress syndrome – The Lancet Respiratory Medicine

Related:

Review: Personalized mechanical ventilation in acute respiratory distress syndrome.

Seminar | Acute respiratory distress syndrome.

M-A of randomized trials: In patients with acute respiratory distress syndrome, there was no difference in mortality between higher vs. lower positive end-expiratory pressure strategies.

M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS

M-A: Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids

ARDS: Contemporary management and novel approaches during COVID-19

Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome

Current and evolving standards of care for patients with acute respiratory distress syndrome (ARDS). Definition, ventilatory support, fluid management, use of corticosteroids, indications of prone positioning and ECMO, and more.

 

COVID vaccines to reach poorest countries in 2023 — “Amid a COVID surge in Africa, vaccine promises from richer nations are not enough to bring an early end to the pandemic, experts say”.

26 Jul, 2021 | 02:51h | UTC

COVID vaccines to reach poorest countries in 2023 — despite recent pledges – Nature

 

International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes.

26 Jul, 2021 | 02:27h | UTC

International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes – Annals of Thoracic Surgery

 

Commentary on Twitter

 

M-A: Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications.

26 Jul, 2021 | 02:24h | UTC

Low-molecular-weight heparin for prevention of preeclampsia and other placenta-mediated complications: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology

 

WHO Guideline on the prevention of drowning through provision of day-care and basic swimming and water safety skills.

26 Jul, 2021 | 02:30h | UTC

WHO Guideline on the prevention of drowning through provision of day-care and basic swimming and water safety skills – World health Organization

See also: World Drowning Prevention Day 2021 (25 July)

News release: Drowning is a leading cause of accidental death – United Nations

Related:

AAP Technical Report | Prevention of Drowning.

The Burden of Unintentional Drowning: Global, Regional and National Estimates of Mortality from the Global Burden of Disease Study

Preventing drowning: an implementation guide – World Health Organization

Global report on drowning: preventing a leading killer – World Health Organization

Report: Open Water Drowning and Risks for Children

Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update – Wilderness and Environmental Medicine

 

Commentary on Twitter (thread – click for more)

 

Review: Dietary carbohydrates and fats in nonalcoholic fatty liver disease.

26 Jul, 2021 | 02:22h | UTC

Dietary carbohydrates and fats in nonalcoholic fatty liver disease – Nature Reviews Gastroenterology & Hepatology (free for a limited period)

 

Commentary on Twitter

 

Clinical practice guidelines for the medical management of Graves’ orbitopathy.

26 Jul, 2021 | 02:26h | UTC

The 2021 European Group on Graves’ Orbitopathy (EUGOGO) Clinical Practice Guidelines for The Medical Management of Graves’ Orbitopathy – European Journal of Endocrinology

 

Editorial | Antibiotic overuse: managing uncertainty and mitigating against overtreatment.

26 Jul, 2021 | 02:16h | UTC

Antibiotic overuse: managing uncertainty and mitigating against overtreatment – BMJ Quality & Safety

 

Commentary on Twitter

 

Review: Timing and completeness of revascularization in acute coronary syndromes.

26 Jul, 2021 | 02:21h | UTC

Timing and completeness of revascularisation in acute coronary syndromes – Heart

 

Commentary on Twitter

 

Cohort study: Higher intake of ultra-processed food linked to increased risk of inflammatory bowel disease.

26 Jul, 2021 | 02:13h | UTC

Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study – The BMJ

Commentaries:

Ultra-processed food linked to higher risk of IBD – BMJ

International study links ultra-processed foods with IBD risk – Medical News Today

 

RCT: Real time remote symptom monitoring during chemotherapy for cancer may reduce symptom burden and improve quality of life.

26 Jul, 2021 | 02:18h | UTC

Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART) – The BMJ

Commentaries:

Remote 24-hour monitoring shows sizable, positive effect on cancer patients – BMJ

Remote Monitoring System Reduces Chemotherapy Symptom Burden – HealthDay

eSMART trial adds support for remote symptom monitoring in people with cancer – medwire News

Related:

Study: Cancer patients benefit from using automated device to manage their symptoms

Study: Web-Based Symptom Monitoring Increases Overall Survival in Lung Cancer

#ASCO2017 – Survival in a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Cancer Treatment

 

Commentary on Twitter

 

Sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus in adults: An overview of 46 systematic reviews.

26 Jul, 2021 | 02:14h | UTC

Sodium-glucose cotransporter-2 inhibitors for type 2 diabetes mellitus in adults: An overview of 46 systematic reviews – Diabetes, Obesity and Metabolism

 

M-A of cohort studies: Meat consumption and risk of ischemic heart disease.

26 Jul, 2021 | 02:09h | UTC

Meat consumption and risk of ischemic heart disease: A systematic review and meta-analysis – Critical Reviews in Food Science and Nutrition

Commentary: Red and processed meat linked to increased risk of heart disease, Oxford study shows – Oxford University

 

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