Daily Archives: July 14, 2021
RCT: Lopinavir-ritonavir and hydroxychloroquine worsened outcomes in critically ill patients with COVID-19.
14 Jul, 2021 | 11:25h | UTC
Commentary on Twitter (thread – click for more)
Results of @remap_cap #Covid_19 #Antiviral Domain released Online First @yourICM: Among critically ill patients with COVID-19, #lopinavir-ritonavir, #HydroxyChloroquine, or combination therapy worsened outcomes compared to no antiviral therapy
— remap-cap (@remap_cap) July 13, 2021
Opinion | The case for mandating COVID-19 vaccines for health care workers.
14 Jul, 2021 | 11:22h | UTCThe Case for Mandating COVID-19 Vaccines for Health Care Workers – Annals of Internal Medicine
News release: Case is strong for mandating COVID-19 vaccination for health care workers – American College of Physicians
Commentary on Twitter
The Case for Mandating COVID-19 Vaccines for Health Care Workers https://t.co/pdaBRZdkfG via @AnnalsofIM "The case for mandating SARS-CoV-2 vaccines for health care workers is substantially stronger than the case was for mandating influenza vaccines." I fully agree.
— Kenny Lin, MD, MPH (@kennylinafp) July 12, 2021
RCT: Neither Remdesivir nor Hydroxychloroquine affect viral clearance in hospitalized patients with COVID-19.
14 Jul, 2021 | 11:23h | UTCNews release: Neither remdesivir nor HCQ affect viral clearance in hospitalized patients with COVID-19 – American College of Physicians
Original Study: Evaluation of the Effects of Remdesivir and Hydroxychloroquine on Viral Clearance in COVID-19 – Annals of Internal Medicine
Commentary on Twitter
Newly published research in Annals concludes neither remdesivir nor #hydroxychloroquine affected viral clearance in hospitalized patients with #COVID19 https://t.co/K3qWLUW8uY. pic.twitter.com/ugbjJJ3qI5
— Annals of Int Med (@AnnalsofIM) July 12, 2021
[Preprint] Wastewater genomic testing can effectively track COVID-19 variants of concern.
14 Jul, 2021 | 11:19h | UTCOriginal Study: Assessing multiplex tiling PCR sequencing approaches for detecting genomic variants of SARS-CoV-2 in municipal wastewater – medRxiv
Related: Perspective | Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start. (texts on the subject) AND Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
Commentary on Twitter (thread – click for more)
Excited to share our new preprint assessing different approaches for sequencing SARS-CoV-2 in wastewater! We compared different sample matrices and tiled PCR schemes, and then applied the best combo to track variants of concern in @MetroVancouver: https://t.co/cXFhr1qmAe
— Ryan Ziels (@RyanZiels) June 1, 2021
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
14 Jul, 2021 | 11:20h | UTCBetween BNT162b2 Vaccination and Incidence of SARS-CoV-2 Infection in Pregnant Women – JAMA
Commentary: Pfizer COVID vaccine shows 78% efficacy in pregnancy – CIDRAP
Real-World Evidence: The low validity of temperature screening for COVID-19 triage.
14 Jul, 2021 | 11:11h | UTC
Commentary on Twitter
Temperature screening with infrared thermometers has a sensitivity of 9.43% for PCR+ COVID. https://t.co/GjaKpkUqwU
— Carlos del Rio (@CarlosdelRio7) July 7, 2021
New Zealand children falling ill in high numbers due to Covid ‘immunity debt’.
14 Jul, 2021 | 11:16h | UTCNew Zealand children falling ill in high numbers due to Covid ‘immunity debt’ – The Guardian
Related: New Zealand, where Covid-19 is dormant, fights another respiratory virus – The New York Times
Next steps for wastewater testing to help end this pandemic — and prevent the next one.
14 Jul, 2021 | 11:18h | UTCNext steps for wastewater testing to help end this pandemic — and prevent the next one – STAT
Author interview: A biostatistician on the ‘gold mine’ in our sewers – STAT
Related: Perspective | Sewage sleuths helped an Arizona town beat back Covid-19. For wastewater epidemiology, that’s just the start. (texts on the subject) AND Human Waste Could Be The Next Big Weapon in Controlling COVID-19 – TIME
One COVID vaccine dose yields good protection in elderly, 2 studies find.
14 Jul, 2021 | 11:15h | UTCOne COVID vaccine dose yields good protection in elderly, 2 studies find – CIDRAP
Commentary on Twitter (thread – click for more)
2 research Articles on #COVID19 vaccine effectiveness in older people:
1) Effectiveness of BNT162b2 and ChAdOx1 nCoV-19 COVID-19 vaccination at preventing hospitalisations in people aged at least 80 years: a test-negative, case-control study https://t.co/ELvMCPwSHF— The Lancet Infectious Diseases (@TheLancetInfDis) June 24, 2021
AAP Technical Report | Prevention of Drowning.
14 Jul, 2021 | 11:09h | UTCPrevention of Drowning – Pediatrics
News releases: American Academy of Pediatrics Identifies Children Most at Risk of Drowning and Recommends Layers of Protection to Prevent Tragedy – American Academy of Pediatrics AND New information, research adds to understanding of drowning risks, precautions – AAP News
Related: The Burden of Unintentional Drowning: Global, Regional and National Estimates of Mortality from the Global Burden of Disease Study AND Preventing drowning: an implementation guide – World Health Organization AND Global report on drowning: preventing a leading killer – World Health Organization AND Report: Open Water Drowning and Risks for Children AND Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update – Wilderness and Environmental Medicine
Commentary on Twitter
Drowning is a leading cause of injury-related death in children. In 2018, almost 900 US children younger than 20 years died from drowning. As educators and advocates, pediatricians can play an important role in #DrowningPrevention: https://t.co/P3eLa1M28p #Pediatrics pic.twitter.com/h3YnqyiMDU
— AAP Journals (@AAPJournals) July 13, 2021
WHO: New study highlights unacceptably high global prevalence of syphilis among men who have sex with men.
14 Jul, 2021 | 11:04h | UTCOriginal Study: Prevalence of syphilis among men who have sex with men: a global systematic review and meta-analysis from 2000–20 – The Lancet Global Health
Commentary: Syphilis in men who have sex with men: advancing research and human rights – The Lancet Global Health
Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.
14 Jul, 2021 | 11:07h | UTCNews release: Alcohol consumption linked to more than 740,000 new cancer cases in 2020 – The Lancet
Commentaries: Alcohol caused 740,000 cancer cases globally last year – study – The Guardian AND Expert reaction to study of alcohol and cancer – Science Media Centre
Review: Diagnosis, evaluation, and treatment of adenomyosis.
14 Jul, 2021 | 11:01h | UTCDiagnosis, Evaluation, and Treatment of Adenomyosis – JAMA (free for a limited period)
Review: Diagnosis and treatment of alcohol-associated liver disease.
14 Jul, 2021 | 11:02h | UTCDiagnosis and Treatment of Alcohol-Associated Liver Disease: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis and Treatment of Alcohol-Associated Liver Disease – JAMA
Summary: SGLT2 inhibitors and GLP-1 receptor agonists established and emerging indications.
14 Jul, 2021 | 10:56h | UTCSGLT2 Inhibitors and GLP-1 Receptor Agonists: Indications – American College of Cardiology
Original review: SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications – The Lancet (link to abstract – $ for full-text)
A UK expert consensus approach for managing symptomatic arteriovenous fistula (AVF) stenosis in hemodialysis patients.
14 Jul, 2021 | 10:55h | UTC
Summary | Universal definition and classification of heart failure: a step in the right direction from failure to function.
14 Jul, 2021 | 10:58h | UTC
FDA Safety Alert: hydroxyethyl starch products should not be used unless adequate alternative treatment is unavailable.
14 Jul, 2021 | 10:48h | UTCCommentary: FDA Piles on New Warnings for Blood Volume Expanders – MedPage Today (free registration required)
Related: Hydroxyethyl-starch Solutions (HES) Should no Longer be Used – European Medicines Agency AND Randomized Trial: Hydroxyethyl Starch vs. Saline for Volume Replacement Therapy in High-Risk Patients Undergoing Major Abdominal Surgery AND Systematic Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People
SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe.
14 Jul, 2021 | 10:53h | UTCEditorial: Redefining cardiovascular risk prediction: is the crystal ball clearer now?
Commentary: New risk calculator to save many more lives from heart attack and stroke – University of Cambridge
Commentary on Twitter (thread – click for more)
1/2 SCORE2—a new algorithm derived, calibrated, & validated to predict 10-year risk of first-onset CVD in European populations—enhances the identification of individuals at higher risk of developing CVD across Europe https://t.co/VLYfZyXUek#EHJ #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/0yZTJBdKDK
— European Society of Cardiology Journals (@ESC_Journals) June 17, 2021