Daily Archives: May 17, 2021
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
17 May, 2021 | 08:56h | UTCInvited commentary: Convalescent plasma in patients hospitalised with COVID-19
Commentaries on Twitter
Convalescent plasma:
Yet another example of
Don’t guess, don’t gamble
Randomize… and learn
I’ve heard it said that it was deemed “too difficult” to do a randomised controlled trial. Really? If that’s the case, we must (and can) fix that problem. Pts deserve better. https://t.co/zxIiK5U63v
— Martin Landray (@MartinLandray) May 15, 2021
NEW #COVID19 research—In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Read https://t.co/7Sbe8V9THp. #RECOVERY #RECOVERYtrial pic.twitter.com/D0OLZKxZc4
— The Lancet (@TheLancet) May 16, 2021
[Preprint] Delaying second Pfizer vaccine dose to 12 weeks increases specific antibody response 3.5-fold in people over 80 years of age.
17 May, 2021 | 08:53h | UTCCommentaries: Delaying a COVID vaccine’s second dose boosts immune response – Nature AND Delaying Second Pfizer COVID-19 Vaccine Dose Increases Antibody Response Threefold In Over-80s, Study Finds – Health Policy Watch AND Delay in giving second jabs of Pfizer vaccine improves immunity – The Guardian AND Expert reaction to preprint looking at the immune response in older people after vaccination the Pfizer-BioNTech COVID-19 vaccine with either a 3-week or a 12-week dosing schedule – Science Media Centre
Disease surveillance for the COVID-19 era: time for bold changes.
17 May, 2021 | 08:54h | UTCDisease surveillance for the COVID-19 era: time for bold changes – The Lancet
Commentary on Twitter
Together with esteemed colleagues, we call for bold changes for disease surveillance in the COVID-19 era and beyond.
The time to act is now, but it will require courage, leadership and more collaboration than ever before.https://t.co/s3vL9jt68G pic.twitter.com/ZKBu7wmKNJ
— Chikwe Ihekweazu (@Chikwe_I) May 15, 2021
Modeling study: Delaying second doses of Pfizer-BioNTech and Moderna mRNA vaccines could reduce deaths by up to 20% under certain conditions.
17 May, 2021 | 08:51h | UTCCommentaries: Expert reaction to study looking at the public health impact of delaying the second dose of the Pfizer-BioNTech and Moderna COVID-19 vaccines – Science Media Centre AND Delaying second Covid vaccine doses can save lives, study finds – The Guardian AND Delaying second COVID vaccine dose may prevent deaths under certain conditions – The BMJ
The pandemic surge at home is threatening an Indian vaccinemaker’s bid to protect the world.
17 May, 2021 | 08:42h | UTC
#ACC21 – [Not published yet] RCT: DARE-19: Dapagliflozin is safe, but did not significantly improve outcomes among high-risk patients hospitalized with COVID-19.
17 May, 2021 | 08:49h | UTC
Commentaries on Twitter
DARE-19 trial #ACC21 @ACCinTouch
Dapa did not reduce clinical endpoints in #COVID19, but excellent safety profile
? Do not discontinue SGLT2i in ? for #COVID19
Full slideset available in ?https://t.co/RPi5mpPbbN pic.twitter.com/B9VQdSSAFu
— Enrique Santas (@SantasEnrique) May 16, 2021
DARE-19 findings presented at #ACC21 show #dapagliflozin didn’t significantly ⬇️ risk of organ failure or death or improve recovery in patients hospitalized w/ #COVID19. However, data suggest the SGLT2 inhibitor was well tolerated in acutely ill patients. https://t.co/YjYxbuc952 pic.twitter.com/J4PqwvGpLJ
— American College of Cardiology (@ACCinTouch) May 16, 2021
‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo.
17 May, 2021 | 08:45h | UTC‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo – STAT
India’s COVID-19 crisis: a call for international action.
17 May, 2021 | 08:43h | UTCIndia’s COVID-19 crisis: a call for international action – The Lancet
Commentary on Twitter (thread – click for more)
The team @IndiaCOVIDSOS and others call for international action for India’s COVID-19 crisis in their Lancet paper.https://t.co/T7RvexuMJP@paimadhu @PrakashLab @KrutikaKuppalli @BhramarBioStat @spkalantri @cspramesh pic.twitter.com/QkuYv2QEb6
— Raj Kumar Manna (@rajphys) May 14, 2021
Setting the record straight: There is no ‘Covid heart’.
17 May, 2021 | 08:47h | UTCSetting the record straight: There is no ‘Covid heart’ – STAT
Commentary on Twitter
Why the issue of Covid-19 induced cardiac problems was massively overblown and why screening low-risk patients with MRI and other fancy tests is neither necessary nor wise. https://t.co/HkJFOJ6oeM
— Raffaele Rasoini (@RasoiniR) May 14, 2021
#ACC21 – Practice Changing RCT: In patients with atrial fibrillation (75% maintained on anticoagulation), left atrial appendage occlusion during cardiac surgery reduces the incidence of stroke and systemic embolism (4.8 vs. 7.0%) in the following years.
17 May, 2021 | 08:33h | UTCLeft Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Simple surgery prevents strokes in heart patients – McMaster University AND Occluding the LAA During Surgery Lowers Stroke Risk: LAAOS III – TCTMD
Video: The Left Atrial Appendage Occlusion Study (LAAOS) III
Commentary on Twitter
A visual abstract of the #ACC21 Left Atrial Appendage Occlusion Study III is now available, evaluating surgical #LAAO compared with no occlusion among patients with #AFib undergoing open heart surgery for another indication. https://t.co/3iIhAEuGwk pic.twitter.com/e9Wq6Bp3Zz
— American College of Cardiology (@ACCinTouch) May 15, 2021
#ACC21 – RCT: No significant differences in cardiovascular events or major bleeding between patients receiving 81 mg vs. 325 mg of aspirin daily.
17 May, 2021 | 08:31h | UTCComparative Effectiveness of Aspirin Dosing in Cardiovascular Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: High- and Low-Dose Aspirin Equivalent in ASCVD: ADAPTABLE – TCTMD AND Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-Term Effectiveness – ADAPTABLE – American College of Cardiology
Video: Aspirin Dosing: A Patient-centric Trial Assessing Benefits And Long-term Effectiveness Trial
WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme
17 May, 2021 | 08:40h | UTCCommentaries: Vaccinate vulnerable global poor before children in rich countries, WHO says – The Guardian AND Covid: Delay child vaccinations and share jabs with Covax, says WHO – BBC
#ACC21 – RCT: Tailored, earlier heart failure rehabilitation program has physical and emotional benefits for older patients.
17 May, 2021 | 08:23h | UTCCommentaries: Tailored, earlier heart failure rehab has physical, emotional benefits for patients – National institutes of Health AND REHAB-HF: Tailored Cardiac Rehab Program Improved Function and Quality of Life in Older HF Patients – American College of Cardiology AND Rehabilitation Therapy in Older Acute Heart Failure Patients – REHAB-HF – American College of Cardiology
Commentaries on Twitter
#REHAB-HF #ACC21 innovative intensive rehab improved physical function
-attention to SDOH environment assessment & involvement of family/care givers
-q2 wk trouble shooting discussion
-corrected balance/mobility first to get pts on treadmill w confidence https://t.co/rOmsc6qdq3 pic.twitter.com/V8TugBipUT— Ritu Thamman MD (@iamritu) May 16, 2021
REHAB-HF trial results found novel #CVRehab program tailored to address specific physical impairments in frail/older patients w/ acute #HeartFailure improved physical function & quality of life; did not significantly reduce hospitalizations. https://t.co/f98IdMvqj4 #ACC21 #cvGeri pic.twitter.com/zY8E1WBNmf
— American College of Cardiology (@ACCinTouch) May 16, 2021
#ACC21 – RCT: In patients with STEMI undergoing complete revascularization, an FFR-guided strategy did not improve outcomes compared to an angiography-guided strategy.
17 May, 2021 | 08:26h | UTCMultivessel PCI Guided by FFR or Angiography for Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)
#ACC21 – [Not published yet] RCT: PARADISE-MI: Sacubitril/Valsartan did not outperform ACE inhibitor after myocardial infarction with new onset heart failure.
17 May, 2021 | 08:17h | UTC
#ACC21 – [Not published yet] RCT: Among patients undergoing TAVR, full-dose apixaban is not superior to standard of care (vitamin K antagonist if indication for oral anticoagulation; antiplatelet therapy if no indication).
17 May, 2021 | 08:19h | UTCCommentaries: ATLANTIS: Apixaban Not Superior to Standard Care After TAVR – American College of Cardiology AND ATLANTIS: Apixaban Has No Benefit Over Standard of Care Post-TAVI – TCTMD
2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.
17 May, 2021 | 08:16h | UTCMeta-analysis 1: Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke
Meta-analysis 2: Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation (link to abstract – $ for full-text)
Commentary: Dual vs. Monotherapy Antiplatelet Agents in Secondary Stroke Prevention – American College of Cardiology
Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
Unnecessary care? 1 in 3 patients with advanced dementia and atrial fibrillation still given anticoagulants.
17 May, 2021 | 08:13h | UTCOriginal study: Anticoagulant Use for Atrial Fibrillation Among Persons With Advanced Dementia at the End of Life – JAMA Internal Medicine (free for a limited period)
Editorial: Anticoagulation at the End of Life: Time for a Rational Framework (free for a limited period)
Opinion | Reconceptualizing how to support surrogates making medical decisions for critically ill patients.
17 May, 2021 | 08:08h | UTCReconceptualizing How to Support Surrogates Making Medical Decisions for Critically Ill Patients – JAMA (free for a limited period)
Report: Implementing high-quality primary care – “pay for primary care teams to care for people, not physicians to deliver services”.
17 May, 2021 | 08:11h | UTCOriginal report: Implementing High-Quality Primary Care: Rebuilding the Foundation of Health Care – National Academies of Sciences, Engineering, and Medicine
Pragmatic RCT: Among patients with advanced glaucoma, primary trabeculectomy resulted in similar quality of life and safety outcomes and achieved a lower intraocular pressure compared with primary medication.
17 May, 2021 | 08:06h | UTC