Daily Archives: May 3, 2021
M-A: Tocilizumab reduces the need for mechanical ventilation in COVID-19 patients, but the randomized trials included in the analysis showed it has no significant effect on the risk of mortality or adverse events
3 May, 2021 | 05:44h | UTC
Report: The Epidemics that Didn’t Happen – The lessons that can be learned from epidemics that were contained
3 May, 2021 | 05:41h | UTCThe Epidemics that Didn’t Happen – Prevent Epidemics
Commentaries: ‘The next big one must be prevented’: The lessons the world can learn from epidemics that were contained – STAT AND Former CDC director: We can prevent the next pandemic – CNN AND Learning from the “Near Misses” – Global Health NOW
RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes
3 May, 2021 | 05:47h | UTCInvited commentary: Tocilizumab in COVID-19: some clarity amid controversy – The Lancet
Shift work is associated with positive COVID-19 status in hospitalized patients
3 May, 2021 | 05:36h | UTCShift work is associated with positive COVID-19 status in hospitalised patients – Thorax
Commentary: Shift Work Linked to Increased Risk for COVID-19 Illness – HealthDay
[Preprint] Estimating the early impact of immunization against COVID-19 on deaths among older adults in Brazil
3 May, 2021 | 05:38h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1388290899029938179
Analysis: Why is India having a covid-19 surge?
3 May, 2021 | 05:39h | UTCWhy is India having a covid-19 surge? – The BMJ
See also: India Is Counting Thousands Of Daily COVID Deaths. How Many Is It Missing? – NPR AND Opinion: India’s covid-19 crisis is a dire warning for all countries – The Washington Post AND India’s nightmare: Record high cases, vaccine shortages, hospital fires. – The New York Times AND India coronavirus: New record deaths as virus engulfs India – BBC
M-A: The viral shedding time (VST) determines disease transmission and the duration of infectiousness in SARS-CoV-2 infections – this study found that symptomatic infections, infected adults, persons with chronic diseases, and persons receiving corticosteroid treatment have longer VST
3 May, 2021 | 05:37h | UTC
Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination
3 May, 2021 | 05:43h | UTCSee also: Safety Monitoring of the Janssen (Johnson & Johnson) COVID-19 Vaccine — United States, March–April 2021 – Centers for Disease Control and Prevention AND Updated Recommendations from the Advisory Committee on Immunization Practices for Use of the Janssen (Johnson & Johnson) COVID-19 Vaccine After Reports of Thrombosis with Thrombocytopenia Syndrome Among Vaccine Recipients — United States, April 2021 – Centers for Disease Control and Prevention
M-A: Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease – “a 5 mm Hg reduction of systolic BP reduced the risk of major CV events by about 10%, irrespective of previous diagnoses of CV disease, and even at normal or high–normal BP values”
3 May, 2021 | 05:29h | UTCCommentaries: Many more people could benefit from blood pressure-lowering medication – The Lancet AND Decisions about antihypertensive treatment should focus on reducing cardiovascular risk – The Lancet
Highly Recommended (video): The Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl)
3 May, 2021 | 05:32h | UTCThe Culture Of Medicine Kills Doctors And Patients (w/Dr. Robert Pearl) – ZDoggMD
Study: Patients with heart failure have a much higher incidence of pneumonia than matched individuals in the population. The development of pneumonia in these patients is associated with a 3- to 4-fold higher risk of cardiovascular and all-cause death.
3 May, 2021 | 05:18h | UTCCommentaries: Pneumonia in HF Patients Is Common, Lethal, and Preventable – TCTMD AND Outcomes of Pneumonia in Patients With Heart Failure – American College of Cardiology
ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding – RBC transfusion at a threshold of 7 g/dL; Erythromycin infusion is suggested before endoscopy; and endoscopy is suggested within 24 hours after presentation.
3 May, 2021 | 05:27h | UTC
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury – antimicrobials, herbal and dietary supplements, and anticancer therapeutics are the most common classes of agents
3 May, 2021 | 05:22h | UTC
Randomized trial: Admission Avoidance Hospital at Home + Geriatric Assessment led to similar outcomes compared to hospital admission for older persons
3 May, 2021 | 05:13h | UTCIs Comprehensive Geriatric Assessment Admission Avoidance Hospital at Home an Alternative to Hospital Admission for Older Persons? A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient
Study: Despite clinical practice guidelines recommending cervical cancer screening every 3 years or cotesting with HPV and cytologic testing every 5 years, many women get tested much more often
3 May, 2021 | 05:19h | UTC
RCT: Discontinuing nasal continuous positive airway pressure either at 5 cm H2O vs. 3 cm H2O in infants ≤32 weeks of gestational age
3 May, 2021 | 05:15h | UTCDiscontinuing Nasal Continuous Positive Airway Pressure in Infants ≤32 Weeks of Gestational Age: A Randomized Control Trial – The Journal of Pediatrics (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/DrAbdulRazak_MD/status/1321226454471004160
The Lancet Series | Miscarriage matters
3 May, 2021 | 05:11h | UTCEditorial: Miscarriage: worldwide reform of care is needed
- Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
- Sporadic miscarriage: evidence to provide effective care
- Recurrent miscarriage: evidence to accelerate action
Study on five million Swedes finds links between blood groups and disease risks
3 May, 2021 | 05:09h | UTCNews Release: Study on five million Swedes finds links between blood groups and disease risks – Karolinska Institutet
Original Study: An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk – eLife